EA200802409A1 - Пробиотический штамм и антимикробный пептид, получаемый с его помощью - Google Patents

Пробиотический штамм и антимикробный пептид, получаемый с его помощью

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Publication number
EA200802409A1
EA200802409A1 EA200802409A EA200802409A EA200802409A1 EA 200802409 A1 EA200802409 A1 EA 200802409A1 EA 200802409 A EA200802409 A EA 200802409A EA 200802409 A EA200802409 A EA 200802409A EA 200802409 A1 EA200802409 A1 EA 200802409A1
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EA
Eurasian Patent Office
Prior art keywords
peptide
antimicrobial
strain
st4sa
mundtii
Prior art date
Application number
EA200802409A
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English (en)
Other versions
EA017558B1 (ru
Inventor
Леон Милнер Теодоре Дикс
Светослав Димитров Тодоров
Хенриетте Кноетзе
Марелизе Бринк
Original Assignee
Сипла Медпро Ресеч Энд Девелопмент (Пти) Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ZA200604035A external-priority patent/ZA200604035B/xx
Application filed by Сипла Медпро Ресеч Энд Девелопмент (Пти) Лтд. filed Critical Сипла Медпро Ресеч Энд Девелопмент (Пти) Лтд.
Publication of EA200802409A1 publication Critical patent/EA200802409A1/ru
Publication of EA017558B1 publication Critical patent/EA017558B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к штамму Enterococcus mundtii, обладающему пробиотическими качествами. Штамм Е. mundtii (ST4SA) вырабатывает антимикробный пептид, который демонстрирует антимикробную активность в отношении широкого спектра бактерий. Изобретение также предусматривает изолированную последовательность нуклеотидов, кодирующую антимикробный пептид (пептид ST4SA). Также изобретение предусматривает процедуру получения пептида настоящего изобретения, согласно которой штамм ST4SA Enterococcus mundtii культивируют в питательной среде при микроаэрофильных условиях и температуре от 10 до 45°С до получения извлекаемого количества упомянутого пептида, после чего пептид извлекают. Изолированный пептид настоящего изобретения может применяться в качестве антимикробного средства в составе жидкого или гелеобразного препарата для местного лечения, а также может использоваться в качестве антимикробного средства после инкапсуляции в полимере.
EA200802409A 2006-05-28 2007-05-25 ШТАММ БАКТЕРИЙ Е.Mundtii ST4SA, СПОСОБНЫЙ ПРОДУЦИРОВАТЬ АНТИБАКТЕРИАЛЬНЫЙ ПЕПТИД ST4SA, СПОСОБ ПОЛУЧЕНИЯ ПЕПТИДА ST4SA И ПРИМЕНЕНИЕ ШТАММА БАКТЕРИЙ Е.Mundtii ST4SA И ПЕПТИДА EA017558B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA200604035A ZA200604035B (en) 2005-05-31 2006-05-28 Improved grenade launcher
PCT/IB2007/051982 WO2007138538A2 (en) 2006-05-28 2007-05-25 Probiotic strain and antimicrobial peptide derived therefrom

Publications (2)

Publication Number Publication Date
EA200802409A1 true EA200802409A1 (ru) 2009-10-30
EA017558B1 EA017558B1 (ru) 2013-01-30

Family

ID=38779065

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802409A EA017558B1 (ru) 2006-05-28 2007-05-25 ШТАММ БАКТЕРИЙ Е.Mundtii ST4SA, СПОСОБНЫЙ ПРОДУЦИРОВАТЬ АНТИБАКТЕРИАЛЬНЫЙ ПЕПТИД ST4SA, СПОСОБ ПОЛУЧЕНИЯ ПЕПТИДА ST4SA И ПРИМЕНЕНИЕ ШТАММА БАКТЕРИЙ Е.Mundtii ST4SA И ПЕПТИДА

Country Status (13)

Country Link
US (2) US7951385B2 (ru)
EP (1) EP2021457B1 (ru)
JP (1) JP2009538614A (ru)
KR (1) KR101521123B1 (ru)
CN (1) CN101454440B (ru)
AP (1) AP2841A (ru)
AU (1) AU2007266675B2 (ru)
CA (1) CA2647161A1 (ru)
EA (1) EA017558B1 (ru)
IL (2) IL195520A0 (ru)
NO (1) NO20084577L (ru)
NZ (1) NZ571619A (ru)
WO (1) WO2007138538A2 (ru)

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RU2794803C1 (ru) * 2021-12-10 2023-04-25 Федеральное бюджетное учреждение науки "Государственный научный центр прикладной микробиологии и биотехнологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ очистки мундтицина Р436 (КС)

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WO2011045764A1 (en) * 2009-10-15 2011-04-21 Cipla Medpro Research And Development (Pty) Ltd A product for delivering antimicrobially active substances to an infected site
WO2012060312A1 (ja) * 2010-11-05 2012-05-10 国立大学法人広島大学 籾殻または玄米から単離された植物乳酸菌およびその利用
WO2012148891A1 (en) * 2011-04-29 2012-11-01 Evonik Degussa Corporation Peptide-lipid conjugates and uses thereof
RU2532227C1 (ru) * 2013-10-23 2014-10-27 Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) Штамм enterоcoccus mundtii, продуцирующий субстанцию пептидной природы с антилистериозной активностью
RU2599430C1 (ru) * 2015-07-23 2016-10-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет" ШТАММ ЛАКТОБАКТЕРИЙ Enterococcus mundtii - ПРОДУЦЕНТ МОЛОЧНОЙ КИСЛОТЫ И АНТИБИОТИЧЕСКИХ ВЕЩЕСТВ
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JP7284156B2 (ja) * 2017-09-19 2023-05-30 アドバクシス， インコーポレイテッド 細菌またはＬｉｓｔｅｒｉａ株の凍結乾燥のための組成物および方法
KR102636571B1 (ko) * 2018-01-31 2024-02-15 누트리 컴퍼니 리미티드 폐렴구균 감염증의 예방 및/또는 치료제
KR102076089B1 (ko) 2018-10-02 2020-02-11 서울대학교 산학협력단 니신 z 생산능이 우수한 락토코커스 락티스 서브스페시스 락티스 ldtm 6804 신균주(kctc 13564bp)
CN109456911B (zh) * 2018-10-10 2019-10-18 南京林业大学 一株蒙氏肠球菌HcM7及其应用
CN110846260B (zh) * 2019-12-18 2021-03-02 江南大学 一株降低生物胺的肉葡萄球菌及其应用
KR102951826B1 (ko) * 2023-01-18 2026-04-13 조선대학교산학협력단 오리 유래 항균 펩타이드로부터 설계된 신규 항균 펩타이드 및 이의 용도
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2794803C1 (ru) * 2021-12-10 2023-04-25 Федеральное бюджетное учреждение науки "Государственный научный центр прикладной микробиологии и биотехнологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ очистки мундтицина Р436 (КС)

Also Published As

Publication number Publication date
IL195520A0 (en) 2011-08-01
KR20090023626A (ko) 2009-03-05
KR101521123B1 (ko) 2015-05-19
JP2009538614A (ja) 2009-11-12
CN101454440B (zh) 2013-05-29
AP2841A (en) 2014-02-28
US20110268703A1 (en) 2011-11-03
WO2007138538A3 (en) 2008-04-17
EA017558B1 (ru) 2013-01-30
CA2647161A1 (en) 2007-12-06
US8444998B2 (en) 2013-05-21
AU2007266675A1 (en) 2007-12-06
AU2007266675B2 (en) 2012-09-06
NZ571619A (en) 2011-10-28
WO2007138538A2 (en) 2007-12-06
US20090297482A1 (en) 2009-12-03
US7951385B2 (en) 2011-05-31
CN101454440A (zh) 2009-06-10
EP2021457B1 (en) 2015-02-11
IL250634A0 (en) 2017-03-30
AP2008004626A0 (en) 2008-10-31
NO20084577L (no) 2008-12-19
EP2021457A2 (en) 2009-02-11

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