EA201190203A1 - Способ получения сложного эфира бифенил-2-илкарбаминовой кислоты - Google Patents

Способ получения сложного эфира бифенил-2-илкарбаминовой кислоты

Info

Publication number
EA201190203A1
EA201190203A1 EA201190203A EA201190203A EA201190203A1 EA 201190203 A1 EA201190203 A1 EA 201190203A1 EA 201190203 A EA201190203 A EA 201190203A EA 201190203 A EA201190203 A EA 201190203A EA 201190203 A1 EA201190203 A1 EA 201190203A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ilkarbaminic
acid
obtaining complex
complex ether
ether biphenyl
Prior art date
Application number
EA201190203A
Other languages
English (en)
Other versions
EA022030B1 (ru
Inventor
Дин Дейвид Эдни
Мэттью Питер Джон
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA201190203A1 publication Critical patent/EA201190203A1/ru
Publication of EA022030B1 publication Critical patent/EA022030B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Раскрыт способ получения соединения формулы (II)включающий взаимодействие соединения формулы (VI)с соединением формулы (IV)в подходящем растворителе.
EA201190203A 2009-04-14 2010-04-14 Способ получения 1-[2-(2-хлор-4-формил-5-метоксифенилкарбамоил)этил]пиперидин-4-илового эфира бифенил-2-илкарбаминовой кислоты EA022030B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16904609P 2009-04-14 2009-04-14
PCT/EP2010/054893 WO2010119064A1 (en) 2009-04-14 2010-04-14 Process for the preparation of a biphenyl-2-ylcarbamic acid ester

Publications (2)

Publication Number Publication Date
EA201190203A1 true EA201190203A1 (ru) 2012-05-30
EA022030B1 EA022030B1 (ru) 2015-10-30

Family

ID=42224367

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190203A EA022030B1 (ru) 2009-04-14 2010-04-14 Способ получения 1-[2-(2-хлор-4-формил-5-метоксифенилкарбамоил)этил]пиперидин-4-илового эфира бифенил-2-илкарбаминовой кислоты

Country Status (15)

Country Link
US (1) US8519138B2 (ru)
EP (1) EP2419409B1 (ru)
JP (2) JP5540075B2 (ru)
KR (1) KR101720154B1 (ru)
CN (1) CN102395563B (ru)
AU (1) AU2010238504B2 (ru)
BR (1) BRPI1013562B1 (ru)
CA (1) CA2758353C (ru)
EA (1) EA022030B1 (ru)
ES (1) ES2535326T3 (ru)
IL (1) IL215550A (ru)
MX (1) MX2011010934A (ru)
SG (1) SG175023A1 (ru)
WO (1) WO2010119064A1 (ru)
ZA (1) ZA201107378B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT107101A (pt) 2013-08-02 2015-02-02 Univ De Coimbra Painéis flexíveis de aerogel hidrofóbico reforçado com feltro de fibras
CN106632257B (zh) * 2016-12-15 2019-02-12 上海市奉贤区中心医院 Gsk961081及其中间体的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
CN101239971B (zh) * 2003-02-14 2011-07-20 施万制药 联苯衍生物
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP4767842B2 (ja) * 2003-04-01 2011-09-07 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
ES2329586T3 (es) * 2003-11-21 2009-11-27 Theravance, Inc. Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino.
TWI374883B (en) * 2004-08-16 2012-10-21 Theravance Inc Crystalline form of a biphenyl compound
JP2008510015A (ja) * 2004-08-16 2008-04-03 セラヴァンス， インコーポレーテッド β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物
WO2006138218A1 (en) * 2005-06-13 2006-12-28 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
GB0602778D0 (en) 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
TW200811104A (en) * 2006-04-25 2008-03-01 Theravance Inc Crystalline forms of a dimethylphenyl compound

Also Published As

Publication number Publication date
MX2011010934A (es) 2011-11-02
CA2758353A1 (en) 2010-10-21
IL215550A (en) 2016-03-31
CN102395563A (zh) 2012-03-28
CN102395563B (zh) 2015-05-20
BRPI1013562A2 (pt) 2020-08-18
AU2010238504B2 (en) 2015-04-16
IL215550A0 (en) 2011-12-29
ES2535326T3 (es) 2015-05-08
US8519138B2 (en) 2013-08-27
US20120046469A1 (en) 2012-02-23
JP2012523447A (ja) 2012-10-04
EP2419409B1 (en) 2015-01-28
JP5540075B2 (ja) 2014-07-02
JP5714748B2 (ja) 2015-05-07
JP2014193873A (ja) 2014-10-09
WO2010119064A1 (en) 2010-10-21
KR101720154B1 (ko) 2017-03-27
AU2010238504A1 (en) 2011-11-03
KR20120006054A (ko) 2012-01-17
CA2758353C (en) 2017-06-06
BRPI1013562B1 (pt) 2021-08-03
ZA201107378B (en) 2013-03-27
SG175023A1 (en) 2011-11-28
EP2419409A1 (en) 2012-02-22
EA022030B1 (ru) 2015-10-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment