EA201190292A1 - Улучшенная композиция реконструированных сурфактантов, содержащая аналоги сурфактантного белка в (sp-b) и сурфактантного белка с (sp-c) - Google Patents

Улучшенная композиция реконструированных сурфактантов, содержащая аналоги сурфактантного белка в (sp-b) и сурфактантного белка с (sp-c)

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Publication number
EA201190292A1
EA201190292A1 EA201190292A EA201190292A EA201190292A1 EA 201190292 A1 EA201190292 A1 EA 201190292A1 EA 201190292 A EA201190292 A EA 201190292A EA 201190292 A EA201190292 A EA 201190292A EA 201190292 A1 EA201190292 A1 EA 201190292A1
Authority
EA
Eurasian Patent Office
Prior art keywords
surfactant protein
reconstructed
surfactants
improved composition
containing analogues
Prior art date
Application number
EA201190292A
Other languages
English (en)
Other versions
EA021163B1 (ru
Inventor
Фаусто Пиветти
Моника Бокки
Аннамария Сольяни Раскини
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41055357&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201190292(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Publication of EA201190292A1 publication Critical patent/EA201190292A1/ru
Publication of EA021163B1 publication Critical patent/EA021163B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Cosmetics (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

Настоящее изобретение направлено на реконструированный легочный сурфактант, содержащий липидный носитель и комбинацию полипептидного аналога нативного сурфактантного белка SP-C и конкретным полипептидным аналогам нативного сурфактантного белка SP-B. Это изобретение также относится к его фармацевтическим композициям и его применению для лечения или профилактики респираторного дистресс-синдрома (RDS) и других респираторных расстройств.
EA201190292A 2009-06-05 2010-05-31 Улучшенная композиция реконструированных сурфактантов, содержащая аналоги сурфактантного белка в (sp-b) и сурфактантного белка с (sp-c) EA021163B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09162052 2009-06-05
PCT/EP2010/003293 WO2010139442A1 (en) 2009-06-05 2010-05-31 Improved reconstituted surfactant composition containing analogs of surfactant protein b (sp-b) and surfactant protein c (sp-c)

Publications (2)

Publication Number Publication Date
EA201190292A1 true EA201190292A1 (ru) 2012-06-29
EA021163B1 EA021163B1 (ru) 2015-04-30

Family

ID=41055357

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190292A EA021163B1 (ru) 2009-06-05 2010-05-31 Улучшенная композиция реконструированных сурфактантов, содержащая аналоги сурфактантного белка в (sp-b) и сурфактантного белка с (sp-c)

Country Status (35)

Country Link
US (1) US8399406B2 (ru)
EP (1) EP2438086B1 (ru)
JP (1) JP5666569B2 (ru)
KR (1) KR101668137B1 (ru)
CN (1) CN102459327B (ru)
AR (1) AR076973A1 (ru)
AU (1) AU2010256066B2 (ru)
BR (1) BRPI1010120B1 (ru)
CA (1) CA2764454C (ru)
CL (1) CL2011003003A1 (ru)
CO (1) CO6470858A2 (ru)
CY (1) CY1118676T1 (ru)
DK (1) DK2438086T3 (ru)
EA (1) EA021163B1 (ru)
ES (1) ES2621974T3 (ru)
GE (1) GEP20135967B (ru)
HR (1) HRP20170445T1 (ru)
HU (1) HUE034053T2 (ru)
IL (1) IL216718A (ru)
JO (1) JO3226B1 (ru)
LT (1) LT2438086T (ru)
MA (1) MA33374B1 (ru)
ME (1) ME01279B (ru)
MX (1) MX2011012951A (ru)
MY (1) MY159464A (ru)
NZ (1) NZ596848A (ru)
PE (1) PE20120541A1 (ru)
PL (1) PL2438086T3 (ru)
PT (1) PT2438086T (ru)
SG (1) SG176305A1 (ru)
SI (1) SI2438086T1 (ru)
TN (1) TN2011000558A1 (ru)
TW (1) TWI457132B (ru)
UA (1) UA103526C2 (ru)
WO (1) WO2010139442A1 (ru)

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RU2757902C2 (ru) * 2016-12-22 2021-10-22 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Терапевтическая комбинация для лечения развивающейся bpd, содержащая легочный сурфактант и стероид

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CA2691531C (en) 2007-06-22 2016-11-01 Board Of Regents,The University Of Texas System Formation of stable submicron peptide or protein particles by thin film freezing
CA2829629A1 (en) * 2011-03-10 2012-09-13 Board Of Regents, The University Of Texas System Protein nanoparticle dispersions
EP3459556A1 (en) 2012-02-09 2019-03-27 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Synthetic analogs of lung surfactant protein sp-c and their use
AR093569A1 (es) 2012-11-21 2015-06-10 Chiesi Farm Spa Tensioactivos pulmonares reconstituidos
CN104382942A (zh) * 2014-11-05 2015-03-04 烟台东诚药业集团股份有限公司 一种猪肺表面活性物质混悬液制备新工艺
EP3285645B1 (en) 2015-04-22 2020-08-12 Chiesi Farmaceutici S.p.A. System for effective breath-synchronized delivery of medicament to the lungs
EP3106090A1 (en) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System for effective breath-synchronized delivery of medicament to the lungs
US11311691B2 (en) 2015-04-28 2022-04-26 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
WO2017155857A1 (en) * 2016-03-07 2017-09-14 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center COMPOSITIONS AND METHODS FOR ADMINISTERING PPARγ AGONISTS, SURFACTANT PEPTIDES AND PHOSPHOLIPIDS
US11207475B2 (en) 2016-07-28 2021-12-28 Chiesi Farmaceutici S.P.A Method and system for delivery of an aerosolized medicament
KR102395835B1 (ko) 2016-08-24 2022-05-10 키에시 파르마슈티시 엣스. 피. 에이. 재구성된 폐 계면활성제 조성물을 포함하는 안정한 약제학적 제제
AU2017349790A1 (en) 2016-10-26 2019-05-02 Chiesi Farmaceutici S.P.A. Device for facilitating the administration of a medicament to the lung by a catheter
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
KR102781186B1 (ko) 2018-04-23 2025-03-17 키에시 파르마슈티시 엣스. 피. 에이. Bpd의 예방을 위한 폐 계면활성제 및 스테로이드를 포함하는 치료학적 조합물
EP3666316A1 (en) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
EP3666315A1 (en) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
EP3843105A1 (en) 2019-12-23 2021-06-30 PARI Pharma GmbH Control device for aerosol nebulizer system
US12606609B2 (en) 2020-01-28 2026-04-21 Chiesi Farmaceutici S.P.A. Polypeptides having improved properties
JP2024524512A (ja) 2021-07-05 2024-07-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 肺サーファクタントを調製する方法
EP4411745A1 (en) 2023-02-01 2024-08-07 Pari Medical Holding GmbH Medical evaluation method, aerosol nebulizer and medical evaluation system
EP4464236A1 (en) 2023-05-15 2024-11-20 Pari Medical Holding GmbH Method of operating an inhalation device, inhalation device and inhalation device system for providing inhalation process feedback
EP4464354A1 (en) 2023-05-15 2024-11-20 Pari Medical Holding GmbH Method of operating an inhalation device, inhalation device and inhalation device system for providing inhalation process/breath guiding
WO2025024609A1 (en) * 2023-07-25 2025-01-30 Biosuperior Technology, Inc. Polypeptides for lung surfactant compositions
WO2025245275A1 (en) * 2024-05-21 2025-11-27 Molecular Express, Inc. Surfactant preparations for pulmonary delivery, and methods for the preparation and use thereof

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WO2000076535A1 (en) 1999-06-11 2000-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
ITMI20021058A1 (it) * 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
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US8563683B2 (en) 2006-07-20 2013-10-22 University Of Rochester Synthetic lung surfactant and use thereof
BRPI0715317B1 (pt) 2006-10-13 2021-10-05 Chiesi Farmaceutici S.P.A. Surfactantes reconstituídos com propriedades aperfeiçoadas
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2757902C2 (ru) * 2016-12-22 2021-10-22 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Терапевтическая комбинация для лечения развивающейся bpd, содержащая легочный сурфактант и стероид

Also Published As

Publication number Publication date
PL2438086T3 (pl) 2017-07-31
KR20120028892A (ko) 2012-03-23
TWI457132B (zh) 2014-10-21
AU2010256066A1 (en) 2012-01-12
CA2764454A1 (en) 2010-12-09
IL216718A0 (en) 2012-02-29
US8399406B2 (en) 2013-03-19
WO2010139442A1 (en) 2010-12-09
HK1166332A1 (en) 2012-10-26
SI2438086T1 (sl) 2017-05-31
CL2011003003A1 (es) 2012-05-18
AR076973A1 (es) 2011-07-20
KR101668137B1 (ko) 2016-10-20
JP2012528810A (ja) 2012-11-15
MX2011012951A (es) 2011-12-16
ME01279B (me) 2013-06-20
TW201102083A (en) 2011-01-16
PT2438086T (pt) 2017-04-18
CN102459327A (zh) 2012-05-16
IL216718A (en) 2016-08-31
SG176305A1 (en) 2012-01-30
GEP20135967B (en) 2013-11-11
TN2011000558A1 (en) 2013-05-24
AU2010256066B2 (en) 2015-11-26
JP5666569B2 (ja) 2015-02-12
JO3226B1 (ar) 2018-03-08
HUE034053T2 (en) 2018-01-29
EA021163B1 (ru) 2015-04-30
ES2621974T3 (es) 2017-07-05
US20110003733A1 (en) 2011-01-06
NZ596848A (en) 2013-06-28
BRPI1010120A2 (pt) 2019-03-26
HRP20170445T1 (hr) 2017-05-19
DK2438086T3 (en) 2017-04-10
BRPI1010120B1 (pt) 2022-12-06
MY159464A (en) 2017-01-13
CY1118676T1 (el) 2017-07-12
CA2764454C (en) 2018-06-12
CN102459327B (zh) 2015-06-03
LT2438086T (lt) 2017-04-10
MA33374B1 (fr) 2012-06-01
EP2438086A1 (en) 2012-04-11
EP2438086B1 (en) 2017-01-11
PE20120541A1 (es) 2012-05-12
UA103526C2 (ru) 2013-10-25
CO6470858A2 (es) 2012-06-29

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