EA201400030A1 - Способ непрерывного подкожного введения инсулина с использованием фермента, разрушающего хиалуронан - Google Patents

Способ непрерывного подкожного введения инсулина с использованием фермента, разрушающего хиалуронан

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Publication number
EA201400030A1
EA201400030A1 EA201400030A EA201400030A EA201400030A1 EA 201400030 A1 EA201400030 A1 EA 201400030A1 EA 201400030 A EA201400030 A EA 201400030A EA 201400030 A EA201400030 A EA 201400030A EA 201400030 A1 EA201400030 A1 EA 201400030A1
Authority
EA
Eurasian Patent Office
Prior art keywords
enzyme
continuous
subditional
hyaluronane
destructing
Prior art date
Application number
EA201400030A
Other languages
English (en)
Inventor
Дэниел Эдвард Вогн
Дуглас Бойер Мушмор
Грегори Ян Фрост
Original Assignee
Галозим, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Галозим, Инк. filed Critical Галозим, Инк.
Publication of EA201400030A1 publication Critical patent/EA201400030A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Предусмотрены способы непрерывной подкожной инфузии инсулина (CSII) с использованием деградирующего гиалуронан фермента, включая рекомбинантную человеческую РН20 (rHuPH20). Эти способы могут быть использованы для более стабильного контроля уровня глюкозы в крови в ходе курса CSII. Эти способы могут быть использованы для лечения субъектов, имеющих диабет или другие связанные с инсулином заболевания или состояния.
EA201400030A 2011-06-17 2012-06-15 Способ непрерывного подкожного введения инсулина с использованием фермента, разрушающего хиалуронан EA201400030A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161520940P 2011-06-17 2011-06-17
US201161628389P 2011-10-27 2011-10-27
US201261657606P 2012-06-08 2012-06-08
PCT/US2012/042818 WO2012174480A2 (en) 2011-06-17 2012-06-15 Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme

Publications (1)

Publication Number Publication Date
EA201400030A1 true EA201400030A1 (ru) 2014-07-30

Family

ID=46642609

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400030A EA201400030A1 (ru) 2011-06-17 2012-06-15 Способ непрерывного подкожного введения инсулина с использованием фермента, разрушающего хиалуронан

Country Status (12)

Country Link
US (1) US20130022592A1 (ru)
EP (1) EP2720713A2 (ru)
JP (1) JP5890516B2 (ru)
KR (1) KR101676543B1 (ru)
CN (1) CN103889443A (ru)
AU (1) AU2012271361B2 (ru)
BR (1) BR112013032265A2 (ru)
CA (1) CA2839512C (ru)
EA (1) EA201400030A1 (ru)
IL (1) IL229750A0 (ru)
MX (1) MX341448B (ru)
WO (1) WO2012174480A2 (ru)

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AU2012271361A1 (en) 2014-01-09
KR101676543B1 (ko) 2016-11-15
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US20130022592A1 (en) 2013-01-24
BR112013032265A2 (pt) 2016-12-20
EP2720713A2 (en) 2014-04-23
JP2014518217A (ja) 2014-07-28
WO2012174480A2 (en) 2012-12-20
JP5890516B2 (ja) 2016-03-22
IL229750A0 (en) 2014-01-30
CN103889443A (zh) 2014-06-25
MX341448B (es) 2016-08-19
MX2013014921A (es) 2014-02-11
AU2012271361B2 (en) 2017-03-02
CA2839512C (en) 2018-01-02
KR20140039304A (ko) 2014-04-01
CA2839512A1 (en) 2012-12-20

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