EA201400031A1 - Стабильные составы на основе фермента, разрушающего хиалуронан - Google Patents

Стабильные составы на основе фермента, разрушающего хиалуронан

Info

Publication number
EA201400031A1
EA201400031A1 EA201400031A EA201400031A EA201400031A1 EA 201400031 A1 EA201400031 A1 EA 201400031A1 EA 201400031 A EA201400031 A EA 201400031A EA 201400031 A EA201400031 A EA 201400031A EA 201400031 A1 EA201400031 A1 EA 201400031A1
Authority
EA
Eurasian Patent Office
Prior art keywords
enzyme
hyaluronane
destructing
compositions based
stable compositions
Prior art date
Application number
EA201400031A
Other languages
English (en)
Inventor
Цунг Хорнг Янг
Майкл Джеймс Лэбарри
Дэниел Эдвард Вогн
Кристофер Л. Кэстер
Франсуа Николь
Донгхьюн Ким
Original Assignee
Галозим, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Галозим, Инк. filed Critical Галозим, Инк.
Publication of EA201400031A1 publication Critical patent/EA201400031A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предусмотрены композиции, которые представляют собой стабильные композиции деградирующего гиалуронан фермента или представляют собой стабильные совместные композиции быстродействующего инсулина и деградирующего гиалуронан фермента, включающие рекомбинантную человеческую РН20 (rHuPH20).
EA201400031A 2011-06-17 2012-06-15 Стабильные составы на основе фермента, разрушающего хиалуронан EA201400031A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161520962P 2011-06-17 2011-06-17
PCT/US2012/042816 WO2012174478A2 (en) 2011-06-17 2012-06-15 Stable formulations of a hyaluronan-degrading enzyme

Publications (1)

Publication Number Publication Date
EA201400031A1 true EA201400031A1 (ru) 2014-07-30

Family

ID=46513830

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201400031A EA201400031A1 (ru) 2011-06-17 2012-06-15 Стабильные составы на основе фермента, разрушающего хиалуронан
EA201501068A EA033472B1 (ru) 2011-06-17 2012-06-15 Композиция для стабилизации гиалуронидазы и ее применение

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201501068A EA033472B1 (ru) 2011-06-17 2012-06-15 Композиция для стабилизации гиалуронидазы и ее применение

Country Status (13)

Country Link
EP (1) EP2720712B1 (ru)
JP (3) JP2014518216A (ru)
KR (2) KR101874401B1 (ru)
CN (2) CN105797140B (ru)
AU (2) AU2012271359B2 (ru)
BR (1) BR112013032396A2 (ru)
CA (1) CA2839511C (ru)
EA (2) EA201400031A1 (ru)
ES (1) ES2566549T3 (ru)
IL (1) IL229749A0 (ru)
MX (1) MX340172B (ru)
NZ (2) NZ618331A (ru)
WO (1) WO2012174478A2 (ru)

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Also Published As

Publication number Publication date
WO2012174478A2 (en) 2012-12-20
JP6224802B2 (ja) 2017-11-01
KR20140043438A (ko) 2014-04-09
MX340172B (es) 2016-06-28
CA2839511C (en) 2018-07-31
IL229749A0 (en) 2014-01-30
EP2720712B1 (en) 2016-03-02
ES2566549T3 (es) 2016-04-13
EA033472B1 (ru) 2019-10-31
JP2017036313A (ja) 2017-02-16
AU2012271359A1 (en) 2014-01-09
NZ717728A (en) 2016-04-29
MX2013014923A (es) 2014-02-11
JP2017197556A (ja) 2017-11-02
KR101874401B1 (ko) 2018-07-04
WO2012174478A9 (en) 2013-05-30
EP2720712A2 (en) 2014-04-23
CN103974715A (zh) 2014-08-06
JP2014518216A (ja) 2014-07-28
CA2839511A1 (en) 2012-12-20
BR112013032396A2 (pt) 2016-11-22
AU2016202472B2 (en) 2017-02-02
EA201501068A1 (ru) 2016-07-29
WO2012174478A3 (en) 2013-04-11
CN105797140B (zh) 2020-08-11
KR20170116173A (ko) 2017-10-18
NZ618331A (en) 2016-04-29
CN105797140A (zh) 2016-07-27
AU2012271359B2 (en) 2016-05-19

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