EA201400521A1 - Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их получения - Google Patents
Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их полученияInfo
- Publication number
- EA201400521A1 EA201400521A1 EA201400521A EA201400521A EA201400521A1 EA 201400521 A1 EA201400521 A1 EA 201400521A1 EA 201400521 A EA201400521 A EA 201400521A EA 201400521 A EA201400521 A EA 201400521A EA 201400521 A1 EA201400521 A1 EA 201400521A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- methods
- receiving
- medicines containing
- indicated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000003837 Epithelial Sodium Channels Human genes 0.000 abstract 1
- 108090000140 Epithelial Sodium Channels Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
В заявке описаны соединения общей формулы (I)и их таутомеры и соли, предпочтительно их фармацевтически приемлемые соли с неорганическими или органическими кислотами и основаниями, которые обладают ценными фармакологическими характеристиками, в особенности ингибирующим воздействием на эпителиальные натриевые каналы, их применение для лечения заболеваний, в особенности заболеваний легких и дыхательных путей.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11187553 | 2011-11-02 | ||
| PCT/EP2012/071352 WO2013064450A1 (en) | 2011-11-02 | 2012-10-29 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EA201400521A1 true EA201400521A1 (ru) | 2014-09-30 |
| EA025158B1 EA025158B1 (ru) | 2016-11-30 |
| EA025158B9 EA025158B9 (ru) | 2018-03-30 |
Family
ID=47073464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201400521A EA025158B9 (ru) | 2011-11-02 | 2012-10-29 | Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их получения |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US8759349B2 (ru) |
| EP (1) | EP2773633B1 (ru) |
| JP (1) | JP6091513B2 (ru) |
| KR (1) | KR102006612B1 (ru) |
| CN (2) | CN106279110B (ru) |
| AP (1) | AP2014007670A0 (ru) |
| AU (1) | AU2012331274B2 (ru) |
| BR (1) | BR112014010583A2 (ru) |
| CA (1) | CA2854217C (ru) |
| CL (1) | CL2014001047A1 (ru) |
| CO (1) | CO6940429A2 (ru) |
| CY (1) | CY1120974T1 (ru) |
| DK (1) | DK2773633T3 (ru) |
| EA (1) | EA025158B9 (ru) |
| EC (1) | ECSP14001929A (ru) |
| ES (1) | ES2645744T3 (ru) |
| GE (2) | GEAP201813485A (ru) |
| HR (1) | HRP20171614T1 (ru) |
| HU (1) | HUE034929T2 (ru) |
| IL (1) | IL232035A (ru) |
| LT (1) | LT2773633T (ru) |
| ME (1) | ME02905B (ru) |
| MX (1) | MX348522B (ru) |
| NO (1) | NO2773633T3 (ru) |
| PE (1) | PE20141607A1 (ru) |
| PH (1) | PH12014500970B1 (ru) |
| PL (1) | PL2773633T3 (ru) |
| PT (1) | PT2773633T (ru) |
| RS (1) | RS56498B1 (ru) |
| SG (1) | SG11201401907TA (ru) |
| SI (1) | SI2773633T1 (ru) |
| TN (1) | TN2014000180A1 (ru) |
| UA (1) | UA115868C2 (ru) |
| WO (1) | WO2013064450A1 (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| SI2773633T1 (sl) | 2011-11-02 | 2017-11-30 | Boehringer Ingelheim International Gmbh | Heterociklične spojine, zdravila, ki vsebujejo te spojine, njihova uporaba in postopki za njihovo pripravo |
| CN105518000B (zh) * | 2013-07-02 | 2018-09-14 | 加州生物医学研究所 | 用于治疗囊性纤维化的化合物 |
| JP6449870B2 (ja) | 2013-07-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺および気道の疾患を処置するための上皮性ナトリウムチャネルの阻害剤としてのアミロライド型化合物 |
| EP3204358B1 (en) | 2014-10-07 | 2018-09-19 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| RU2712163C2 (ru) | 2014-10-24 | 2020-01-24 | Оно Фармасьютикал Ко., Лтд. | Активатор kcnq2-5 каналов |
| HK1246718A1 (zh) * | 2015-01-07 | 2018-09-14 | 斯克利普斯研究所 | 用於治疗囊性纤维化的化合物 |
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
| CN116438200A (zh) | 2020-09-10 | 2023-07-14 | 普雷西里克斯公司 | 针对fap的抗体片段 |
| CN112107580A (zh) * | 2020-09-29 | 2020-12-22 | 北京鑫开元医药科技有限公司 | 一种脾酪氨酸激酶抑制剂的制剂组合物及其制备方法 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| JP2025517625A (ja) | 2022-05-02 | 2025-06-10 | プレシリックス・ナームローゼ・ベンノートシヤープ | プレターゲティング |
| WO2024243025A1 (en) * | 2023-05-19 | 2024-11-28 | Ikena Oncology, Inc. | Naphthyl-substituted pyrido[4,3-d]pyrimidines and related compounds and their use in treating medical conditions |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6812003A (ru) | 1967-09-07 | 1969-03-11 | ||
| US3953476A (en) | 1971-12-27 | 1976-04-27 | Merck & Co., Inc. | 3-Amino-5-sulfonylbenzoic acids |
| DE60038449T2 (de) | 1999-07-19 | 2009-04-09 | University Of North Carolina At Chapel Hill | Arzneimittelwirkstoffe mit zwei kovalent verknüpften wirkstoffgruppen (natriumkanalblocker/p2y2 rezeptor agonist) zur behandlung von schleimhäuten |
| WO2001052902A1 (en) | 2000-01-24 | 2001-07-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of inducible nitric oxide synthase expression |
| WO2006023573A2 (en) | 2004-08-18 | 2006-03-02 | Johnson Michael R | Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers |
| GB0526244D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| EP2484308A1 (en) * | 2006-07-24 | 2012-08-08 | International Stem Cell Corporation | Synthetic cornea from retinal stem cells |
| US8318935B2 (en) * | 2007-05-07 | 2012-11-27 | Novartis Ag | Organic compounds 75074 |
| EP2231280B1 (en) | 2007-12-10 | 2016-08-10 | Novartis AG | Amiloride-like Pyrazine-carboxamides as ENaC blockers |
| CN102015662A (zh) | 2008-05-13 | 2011-04-13 | 诺瓦提斯公司 | 3,5-二氨基-6-氯-吡嗪-2-甲酸衍生物和它们作为上皮钠通道阻断剂用于治疗气道疾病的用途 |
| BRPI0915018A2 (pt) | 2008-06-10 | 2015-10-27 | Novartis Ag | compostos orgânicos |
| US9050339B2 (en) | 2010-09-17 | 2015-06-09 | Novartis Ag | Pyrazine derivatives as ENaC blockers |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US9072738B2 (en) | 2011-06-27 | 2015-07-07 | Parion Sciences, Inc. | Chemically and metabolically stable dipeptide possessing potent sodium channel blocker activity |
| SI2773633T1 (sl) * | 2011-11-02 | 2017-11-30 | Boehringer Ingelheim International Gmbh | Heterociklične spojine, zdravila, ki vsebujejo te spojine, njihova uporaba in postopki za njihovo pripravo |
| JP2015501324A (ja) | 2011-11-02 | 2015-01-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アシルグアニジン及びアシルチオ尿素の新規調製方法 |
-
2012
- 2012-10-29 SI SI201231100T patent/SI2773633T1/sl unknown
- 2012-10-29 DK DK12777930.4T patent/DK2773633T3/da active
- 2012-10-29 HU HUE12777930A patent/HUE034929T2/en unknown
- 2012-10-29 EA EA201400521A patent/EA025158B9/ru not_active IP Right Cessation
- 2012-10-29 GE GEAP201813485A patent/GEAP201813485A/en unknown
- 2012-10-29 WO PCT/EP2012/071352 patent/WO2013064450A1/en not_active Ceased
- 2012-10-29 RS RS20171069A patent/RS56498B1/sr unknown
- 2012-10-29 AP AP2014007670A patent/AP2014007670A0/xx unknown
- 2012-10-29 KR KR1020147012186A patent/KR102006612B1/ko not_active Expired - Fee Related
- 2012-10-29 HR HRP20171614TT patent/HRP20171614T1/hr unknown
- 2012-10-29 CA CA2854217A patent/CA2854217C/en not_active Expired - Fee Related
- 2012-10-29 LT LTEP12777930.4T patent/LT2773633T/lt unknown
- 2012-10-29 ME MEP-2017-247A patent/ME02905B/me unknown
- 2012-10-29 JP JP2014539297A patent/JP6091513B2/ja active Active
- 2012-10-29 PH PH1/2014/500970A patent/PH12014500970B1/en unknown
- 2012-10-29 NO NO12777930A patent/NO2773633T3/no unknown
- 2012-10-29 CN CN201610685839.2A patent/CN106279110B/zh active Active
- 2012-10-29 PL PL12777930T patent/PL2773633T3/pl unknown
- 2012-10-29 US US13/662,791 patent/US8759349B2/en active Active
- 2012-10-29 EP EP12777930.4A patent/EP2773633B1/en active Active
- 2012-10-29 CN CN201280065806.8A patent/CN104024244B/zh active Active
- 2012-10-29 UA UAA201405764A patent/UA115868C2/uk unknown
- 2012-10-29 GE GEAP201213485A patent/GEP20186880B/en unknown
- 2012-10-29 BR BR112014010583A patent/BR112014010583A2/pt active Search and Examination
- 2012-10-29 PT PT127779304T patent/PT2773633T/pt unknown
- 2012-10-29 MX MX2014005166A patent/MX348522B/es active IP Right Grant
- 2012-10-29 SG SG11201401907TA patent/SG11201401907TA/en unknown
- 2012-10-29 AU AU2012331274A patent/AU2012331274B2/en not_active Ceased
- 2012-10-29 ES ES12777930.4T patent/ES2645744T3/es active Active
- 2012-10-29 PE PE2014000641A patent/PE20141607A1/es active IP Right Grant
-
2014
- 2014-04-09 IL IL232035A patent/IL232035A/en not_active IP Right Cessation
- 2014-04-24 CL CL2014001047A patent/CL2014001047A1/es unknown
- 2014-04-28 TN TNP2014000180A patent/TN2014000180A1/en unknown
- 2014-04-28 US US14/263,344 patent/US20140228374A1/en not_active Abandoned
- 2014-04-30 CO CO14092699A patent/CO6940429A2/es unknown
- 2014-05-26 EC ECIEPI20141929A patent/ECSP14001929A/es unknown
-
2015
- 2015-08-05 US US14/818,478 patent/US9920035B2/en active Active
-
2017
- 2017-10-30 CY CY171101128T patent/CY1120974T1/el unknown
- 2017-12-13 US US15/840,309 patent/US20180194747A1/en not_active Abandoned
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| TH4A | Publication of the corrected specification to eurasian patent | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG TJ TM |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ RU |