EA201400924A1 - Сконструированные пестицидные белки - Google Patents

Сконструированные пестицидные белки

Info

Publication number
EA201400924A1
EA201400924A1 EA201400924A EA201400924A EA201400924A1 EA 201400924 A1 EA201400924 A1 EA 201400924A1 EA 201400924 A EA201400924 A EA 201400924A EA 201400924 A EA201400924 A EA 201400924A EA 201400924 A1 EA201400924 A1 EA 201400924A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polypeptides
organisms
pesticidal
constructed
pesticidal proteins
Prior art date
Application number
EA201400924A
Other languages
English (en)
Other versions
EA031448B1 (ru
Inventor
Микун Ли
Цзэншун Чэнь
Черил Мари Де-Фонте
Джаред Конвилл
Наренда Палекар
Original Assignee
Зингента Партисипейшнс Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зингента Партисипейшнс Аг filed Critical Зингента Партисипейшнс Аг
Publication of EA201400924A1 publication Critical patent/EA201400924A1/ru
Publication of EA031448B1 publication Critical patent/EA031448B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Insects & Arthropods (AREA)
  • Agronomy & Crop Science (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Раскрыты сконструированные пестицидные полипептиды, являющиеся высокоактивными против широкого спектра вредителей, и способы получения таких полипептидов. Нуклеотидные последовательности, кодирующие пестицидный полипептид, можно применять для трансформации различных прокариотических и эукариотических организмов, при этом организмы можно применять для получения пестицидных полипептидов. Рекомбинантные организмы и/или полипептиды, вырабатываемые рекомбинантными организмами, можно применять для борьбы с вредителями в различных условиях окружающей среды.
EA201400924A 2012-02-16 2013-01-23 Сконструированные пестицидные белки EA031448B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261599583P 2012-02-16 2012-02-16
PCT/US2013/022685 WO2013122720A2 (en) 2012-02-16 2013-01-23 Engineered pesticidal proteins

Publications (2)

Publication Number Publication Date
EA201400924A1 true EA201400924A1 (ru) 2015-07-30
EA031448B1 EA031448B1 (ru) 2019-01-31

Family

ID=47682062

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400924A EA031448B1 (ru) 2012-02-16 2013-01-23 Сконструированные пестицидные белки

Country Status (16)

Country Link
US (2) US10023876B2 (ru)
EP (1) EP2814965B1 (ru)
CN (1) CN104145020B (ru)
AR (1) AR090070A1 (ru)
AU (2) AU2013219927B2 (ru)
BR (1) BR112014020164B1 (ru)
CA (1) CA2860626C (ru)
CL (1) CL2014002148A1 (ru)
EA (1) EA031448B1 (ru)
ES (1) ES2670505T3 (ru)
MX (1) MX356581B (ru)
PH (1) PH12014501854A1 (ru)
PT (1) PT2814965T (ru)
UA (1) UA116881C2 (ru)
WO (1) WO2013122720A2 (ru)
ZA (1) ZA201405056B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016019270A1 (en) * 2014-07-31 2016-02-04 Academia Sinica An antagonistic pd-1 aptamer and its applications in cancer therapy related applications
CA2957821A1 (en) 2014-08-29 2016-03-03 Syngenta Participations Ag Modified vip3 polypeptides
RU2765304C2 (ru) 2016-08-09 2022-01-28 Зингента Партисипейшнс Аг Инсектицидные белки
EP3688013A4 (en) * 2017-09-26 2021-05-12 Dow Agrosciences LLC CHIMERIC INSECTICIDAL PROTEINS
KR102198072B1 (ko) * 2020-03-04 2021-01-04 씨제이제일제당 주식회사 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법
WO2022144904A1 (en) * 2021-01-04 2022-07-07 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Institute) Anti-pest toxins and cells
KR20240127466A (ko) * 2022-01-06 2024-08-22 디씨엠 스리람 리미티드 살곤충성 단백질 및 그의 용도
CN114907458B (zh) * 2022-05-10 2023-12-22 山东大学 一种活性提高的Vip3A突变蛋白及其应用
AU2023332832A1 (en) * 2022-09-01 2025-01-30 Qingdao Kingagroot Seed Science Co., Ltd. A MUTANT INSECTICIDAL PROTEIN Vip3 AND ITS APPLICATION
AR134711A1 (es) 2023-12-18 2026-03-04 Syngenta Crop Protection Ag Formulación
CN120554468A (zh) * 2024-02-28 2025-08-29 青岛清原种子科学有限公司 Vip3Aa突变蛋白及其在控制害虫上的应用

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535060A (en) 1983-01-05 1985-08-13 Calgene, Inc. Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthetase, production and use
US4761373A (en) 1984-03-06 1988-08-02 Molecular Genetics, Inc. Herbicide resistance in plants
ATE100141T1 (de) 1984-03-06 1994-01-15 Mgi Pharma Inc Herbizide resistenz in pflanzen.
US5100792A (en) 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5036006A (en) 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4940835A (en) 1985-10-29 1990-07-10 Monsanto Company Glyphosate-resistant plants
US4810648A (en) 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
ATE57390T1 (de) 1986-03-11 1990-10-15 Plant Genetic Systems Nv Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen.
US4975374A (en) 1986-03-18 1990-12-04 The General Hospital Corporation Expression of wild type and mutant glutamine synthetase in foreign hosts
NZ221259A (en) 1986-07-31 1990-05-28 Calgene Inc Seed specific transcriptional regulation
US5273894A (en) 1986-08-23 1993-12-28 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US5276268A (en) 1986-08-23 1994-01-04 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US5013659A (en) 1987-07-27 1991-05-07 E. I. Du Pont De Nemours And Company Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
TR27832A (tr) 1987-04-29 1995-08-31 Monsanto Co Zararli ucucu hasarata mukavim bitkiler.
US6040504A (en) 1987-11-18 2000-03-21 Novartis Finance Corporation Cotton promoter
US5614395A (en) 1988-03-08 1997-03-25 Ciba-Geigy Corporation Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
EP0332104A3 (en) 1988-03-08 1991-03-20 Ciba-Geigy Ag Chemically regulatable dna sequences and genes and uses thereof
ATE112314T1 (de) 1988-05-17 1994-10-15 Lubrizol Genetics Inc Pflanzliches ubiquitinpromotorsystem.
NZ230375A (en) 1988-09-09 1991-07-26 Lubrizol Genetics Inc Synthetic gene encoding b. thuringiensis insecticidal protein
US5162602A (en) 1988-11-10 1992-11-10 Regents Of The University Of Minnesota Corn plants tolerant to sethoxydim and haloxyfop herbicides
EP1103616A3 (en) 1989-02-24 2001-06-27 Monsanto Company Synthetic plant genes and method for preparation
KR920701453A (ko) 1989-03-17 1992-08-11 미리엄 디. 멕코나헤이 유전자발현의 외부조절
US5641876A (en) 1990-01-05 1997-06-24 Cornell Research Foundation, Inc. Rice actin gene and promoter
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
ES2187497T3 (es) 1990-04-12 2003-06-16 Syngenta Participations Ag Promotores preferentemente en tejidos.
US5451513A (en) 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
US5459252A (en) 1991-01-31 1995-10-17 North Carolina State University Root specific gene promoter
US5767366A (en) 1991-02-19 1998-06-16 Louisiana State University Board Of Supervisors, A Governing Body Of Louisiana State University Agricultural And Mechanical College Mutant acetolactate synthase gene from Ararbidopsis thaliana for conferring imidazolinone resistance to crop plants
JPH06510187A (ja) 1991-08-27 1994-11-17 ノバルティス アクチエンゲゼルシャフト 同翅類昆虫に対する殺虫性質を有したタンパク質及び植物保護におけるそれらの用法
US5994629A (en) 1991-08-28 1999-11-30 Novartis Ag Positive selection
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
US5304730A (en) 1991-09-03 1994-04-19 Monsanto Company Virus resistant plants and method therefore
UA48104C2 (ru) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, содержащий последовательность, которая кодирует инсектицидный протеин, оптимизированную для кукурузы, фрагмент днк, обеспечивающий направленную желательную для сердцевины стебля экспрессию связанного с ней структурного гена в растении, фрагмент днк, обеспечивающий специфическую для пыльцы экспрессию связанного с ней структурного гена в растении, рекомбинантная молекула днк, способ получения оптимизированной для кукурузы кодирующей последовательности инсектицидного протеина, способ защиты растений кукурузы по меньшей мере от одного насекомого-вредителя
US5849870A (en) 1993-03-25 1998-12-15 Novartis Finance Corporation Pesticidal proteins and strains
US5877012A (en) 1993-03-25 1999-03-02 Novartis Finance Corporation Class of proteins for the control of plant pests
DE4317845A1 (de) 1993-05-28 1994-12-01 Bayer Ag Desoxyribonukleinsäuren
US5576198A (en) 1993-12-14 1996-11-19 Calgene, Inc. Controlled expression of transgenic constructs in plant plastids
US5545817A (en) 1994-03-11 1996-08-13 Calgene, Inc. Enhanced expression in a plant plastid
US5545818A (en) 1994-03-11 1996-08-13 Calgene Inc. Expression of Bacillus thuringiensis cry proteins in plant plastids
US5437992A (en) 1994-04-28 1995-08-01 Genencor International, Inc. Five thermostable xylanases from microtetraspora flexuosa for use in delignification and/or bleaching of pulp
US6808904B2 (en) 1994-06-16 2004-10-26 Syngenta Participations Ag Herbicide-tolerant protox genes produced by DNA shuffling
EP0800582B1 (en) 1994-12-30 2007-08-15 Seminis Vegetable Seeds, Inc. Transgenic plants expressing dna constructs containing a plurality of genes to impart virus resistance
GB9515941D0 (en) 1995-08-03 1995-10-04 Zeneca Ltd DNA constructs
US5853973A (en) 1995-04-20 1998-12-29 American Cyanamid Company Structure based designed herbicide resistant products
US6084155A (en) 1995-06-06 2000-07-04 Novartis Ag Herbicide-tolerant protoporphyrinogen oxidase ("protox") genes
GB9516241D0 (en) 1995-08-08 1995-10-11 Zeneca Ltd Dna constructs
GB9611777D0 (en) * 1996-06-06 1996-08-07 Ciba Geigy Ag Method of controlling insect pests
US5849320A (en) 1996-06-13 1998-12-15 Novartis Corporation Insecticidal seed coating
US5876739A (en) 1996-06-13 1999-03-02 Novartis Ag Insecticidal seed coating
US6369213B1 (en) * 1996-07-01 2002-04-09 Mycogen Corporation Toxins active against pests
EP0909324A2 (en) 1996-07-01 1999-04-21 Mycogen Corporation Toxins active against pests
US6603063B1 (en) 1999-05-07 2003-08-05 Mycogen Corp. Plants and cells transformed with a nucleic acid from Bacillus thuringiensis strain KB59A4-6 encoding a novel SUP toxin
WO1998018932A2 (en) 1996-10-30 1998-05-07 Mycogen Corporation Novel pesticidal toxins and nucleotide sequences which encode these toxins
US6242669B1 (en) 1996-10-30 2001-06-05 Mycogen Corporation Pesticidal toxins and nucleotide sequences which encode these toxins
US7129212B2 (en) 1996-10-30 2006-10-31 Mycogen Corporation Polynucleotides, pesticidal proteins, and novel methods of using them
US6121436A (en) 1996-12-13 2000-09-19 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
SE506835C2 (sv) 1997-01-31 1998-02-16 Lennart Svensson Förankringsanordning samt förfarande vid montering av en sådan
EP0972062A2 (en) 1997-04-03 2000-01-19 Novartis AG Plant pest control
NZ504510A (en) 1997-11-18 2002-10-25 Pioneer Hi Bred Int Methods and compositions for increasing efficiency of excision of a viral replicon from T-DNA that is transferred to a plant by agroinfection
CA2309719A1 (en) 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. Targeted manipulation of genes in plants
PT1034262E (pt) 1997-11-18 2005-10-31 Pioneer Hi Bred Int Composicoes e metodos para a modificacao genetica de plantas
AU745960C (en) 1997-11-18 2003-09-18 Pioneer Hi-Bred International, Inc. A novel method for the integration of foreign DNA into eukaryoticgenomes
AR044724A1 (es) 2000-03-27 2005-10-05 Syngenta Participations Ag Promotores del virus de la rizadura amarilla del cestrum
IL151886A (en) 2000-03-27 2010-11-30 Syngenta Participations Ag Cestrum yellow leaf curling virus promoters
AR035799A1 (es) 2001-03-30 2004-07-14 Syngenta Participations Ag Toxinas insecticidas aisladas de bacillus thuringiensis y sus usos.
DE20122553U1 (de) 2001-08-10 2006-03-23 Akzenta Paneele + Profile Gmbh Paneel sowie Befestigungssystem für Paneele
JP2006500908A (ja) 2002-03-06 2006-01-12 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 新規なVip3トキシン及び使用方法
CN100497378C (zh) 2002-03-22 2009-06-10 拜尔生物科学公司 新的苏云金芽孢杆菌杀昆虫蛋白质
CA2479769C (en) * 2002-03-22 2016-01-26 Bayer Bioscience N.V. Novel bacillus thuringiensis insecticidal proteins
WO2005037993A2 (en) 2003-10-06 2005-04-28 Syngenta Participations Ag Promoters functional in plant plastids
MXPA06006670A (es) 2003-12-19 2007-03-21 Syngenta Participations Ag Xilanasas expresadas microbialmente y su uso como aditivos de forraje y otros usos.
US20110047646A1 (en) * 2008-05-01 2011-02-24 Juan Ferre Manzanero Armyworm Insect Resistance Management in Transgenic Plants
EP2300618A1 (en) * 2008-06-13 2011-03-30 Bayer BioScience N.V. Bollworm insect resistance management in transgenic plants

Also Published As

Publication number Publication date
MX356581B (es) 2018-06-05
BR112014020164B1 (pt) 2022-09-13
CA2860626C (en) 2021-05-18
PH12014501854B1 (en) 2014-11-17
EA031448B1 (ru) 2019-01-31
UA116881C2 (uk) 2018-05-25
AU2013219927A1 (en) 2014-08-07
CA2860626A1 (en) 2013-08-22
EP2814965A2 (en) 2014-12-24
AU2018253611B2 (en) 2021-04-01
ZA201405056B (en) 2015-10-28
WO2013122720A2 (en) 2013-08-22
AU2018253611A1 (en) 2018-11-22
CN104145020B (zh) 2020-06-02
AU2013219927B2 (en) 2018-11-08
CL2014002148A1 (es) 2014-11-03
US20150020236A1 (en) 2015-01-15
PT2814965T (pt) 2018-05-23
CN104145020A (zh) 2014-11-12
WO2013122720A3 (en) 2013-12-19
US10023876B2 (en) 2018-07-17
EP2814965B1 (en) 2018-03-21
ES2670505T3 (es) 2018-05-30
MX2014009282A (es) 2014-08-27
BR112014020164A2 (pt) 2017-08-01
AR090070A1 (es) 2014-10-15
US20180291397A1 (en) 2018-10-11
PH12014501854A1 (en) 2014-11-17

Similar Documents

Publication Publication Date Title
AU2018253611A1 (en) Engineered pesticidal proteins
PH12021550899A1 (en) Compositions and Methods for Controlling Plant Pests
MX343876B (es) Plantas resistentes al glifosato y metodos asociados.
JO3519B1 (ar) تركيبات أجسام مضادة لأجل cdh19 و cd3
MX2017006866A (es) Pares de unión para producción de péptidos.
MX2016001555A (es) Modulocinas basadas en dominio sushi de interleucina-15 (il-15) y receptor alfa de interleucina-15 (il-15ra).
MX378451B (es) Variantes de regiòn fc con uniòn del receptor fc neonatal (fcrn) modificado y mètodos de uso.
MX2021000155A (es) Moleculas de proteina multifuncionales que comprenden decorina y su uso.
EP4442268A3 (en) Ctla-4 variant immunomodulatory proteins and uses thereof
PH12015502071A1 (en) Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
MX383817B (es) Composiciones y metodos para controlar plagas de plantas.
MY186864A (en) Fusion immunomodulatory proteins and methods for making same
EP4462121A3 (en) Recombinant glycosylated eculizumab and eculizumab variants
WO2015092335A3 (fr) Proteines recombinantes possedant une activite de facteur h
EA201591609A1 (ru) Варианты альфа-амилазы
JP2016503289A5 (ru)
WO2015015516A3 (en) Expression vector for production of recombinant proteins in prokaryotic host cells
MX359987B (es) Polipéptido con actividad reforzada de beta-glucosidasa a baja temperatura.
UA117785C2 (uk) Виділений ентомотоксичний поліпептид
Il'icheva et al. Producing of a Recombinant Domain of Telomer-Binding Protein TRF2 and Antibodies to it
RU2012133162A (ru) Способ получения рекомбинантных белков в бесклеточных системах синтеза

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM