EA201401046A1 - Устройство и способы печати биологических тканей и органов - Google Patents

Устройство и способы печати биологических тканей и органов

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Publication number
EA201401046A1
EA201401046A1 EA201401046A EA201401046A EA201401046A1 EA 201401046 A1 EA201401046 A1 EA 201401046A1 EA 201401046 A EA201401046 A EA 201401046A EA 201401046 A EA201401046 A EA 201401046A EA 201401046 A1 EA201401046 A1 EA 201401046A1
Authority
EA
Eurasian Patent Office
Prior art keywords
printing
module
organs
radiation
biological tissues
Prior art date
Application number
EA201401046A
Other languages
English (en)
Other versions
EA028039B1 (ru
Inventor
Владимир Александрович МИРОНОВ
Юсеф Джоржевич Хесуани
Александр Николаевич МИТРЯШКИН
Ирина Сергеевна ГЛАДКАЯ
Александр Юрьевич ОСТРОВСКИЙ
Сергей Владимирович НОВОСЕЛОВ
Original Assignee
Частное Учреждение Лаборатория Биотехнологических Исследований "3Д Биопринтинг Солюшенс"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Частное Учреждение Лаборатория Биотехнологических Исследований "3Д Биопринтинг Солюшенс" filed Critical Частное Учреждение Лаборатория Биотехнологических Исследований "3Д Биопринтинг Солюшенс"
Priority to EA201401046A priority Critical patent/EA028039B1/ru
Priority to EP15837477.7A priority patent/EP3190171A4/en
Priority to US15/311,242 priority patent/US11499135B2/en
Priority to PCT/RU2015/000505 priority patent/WO2016036275A1/ru
Publication of EA201401046A1 publication Critical patent/EA201401046A1/ru
Publication of EA028039B1 publication Critical patent/EA028039B1/ru
Priority to US16/665,187 priority patent/US11427802B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Изобретение относится к медицине и биологии, а именно к средствам искусственного создания биологических тканей и органов, и может быть использовано в биотехнологии, биоинженерии, тканевой инженерии, регенеративной медицине, 3Д печати биологических тканей и органов. Сущность изобретения заключается в разработке способа печати биологических тканей и органов, а также устройства для его осуществления. Предлагаемое устройство содержит, по крайней мере, платформу для печати, модуль печати биочернилами, содержащий по меньшей мере одну форсунку, выполненную с возможностью дозирования биочернил, модуль печати гелеобразующей композицией, содержащий УФ-модуль и по меньшей мере одну форсунку, выполненную с возможностью дозирования полимеризующейся под действием УФ-излучения гелеобразующей композиции, и модуль относительного перемещения форсунок и/или платформы, в котором модуль печати биочернилами отделен от модуля печати гелеобразующей композицией так, чтобы исключить попадание УФ-излучения на модуль печати биочернилами, а излучение УФ-модуля направлено преимущественно параллельно плоскости платформы для печати так, чтобы исключить попадание УФ-излучения на печатаемые биологические ткани и/или органы. Технический результат заключается в создании многофункционального устройства, которое способно совмещать разные режимы печати, в обеспечении печати с высоким разрешением биологических тканей и органов на основе полимеризующегося под действием УФ-излучения гидрогеля с высоким разрешением, а также в обеспечении защиты клеток от ультрафиолетового излучения при печати.
EA201401046A 2014-09-05 2014-09-05 Устройство и способы печати биологических тканей и органов EA028039B1 (ru)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EA201401046A EA028039B1 (ru) 2014-09-05 2014-09-05 Устройство и способы печати биологических тканей и органов
EP15837477.7A EP3190171A4 (en) 2014-09-05 2015-08-12 Device and methods for printing biological tissues and organs
US15/311,242 US11499135B2 (en) 2014-09-05 2015-08-12 Device and methods for printing biological tissues and organs
PCT/RU2015/000505 WO2016036275A1 (ru) 2014-09-05 2015-08-12 Устройство и способы печати биологических тканей и органов
US16/665,187 US11427802B2 (en) 2014-09-05 2019-10-28 Method and apparatus for printing biological tissues and organs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201401046A EA028039B1 (ru) 2014-09-05 2014-09-05 Устройство и способы печати биологических тканей и органов

Publications (2)

Publication Number Publication Date
EA201401046A1 true EA201401046A1 (ru) 2016-03-31
EA028039B1 EA028039B1 (ru) 2017-09-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401046A EA028039B1 (ru) 2014-09-05 2014-09-05 Устройство и способы печати биологических тканей и органов

Country Status (4)

Country Link
US (2) US11499135B2 (ru)
EP (1) EP3190171A4 (ru)
EA (1) EA028039B1 (ru)
WO (1) WO2016036275A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022237003A1 (zh) * 2021-05-14 2022-11-17 清华大学 一种构建复杂异质组织/器官的多级悬浮打印方法

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3247281B1 (en) 2015-01-23 2020-12-02 The University of North Carolina at Chapel Hill Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects
KR101795559B1 (ko) * 2016-01-07 2017-11-08 주식회사 티앤알바이오팹 열민감성 세포프린팅 조성물의 세포 프린팅 장치
JP6718967B2 (ja) * 2016-01-29 2020-07-08 ワイ ソフト コーポレーションＹ Ｓｏｆｔ Ｃｏｒｐｏｒａｔｉｏｎ 保護された３ｄプリンタおよび３ｄプリンタ管理ネットワーク
US10345208B2 (en) 2016-07-12 2019-07-09 Deka Products Limited Partnership System and method for applying force to a device
EP4306297A3 (en) * 2016-07-12 2024-04-24 DEKA Products Limited Partnership System and method for printing tissue
US11254901B2 (en) 2016-07-12 2022-02-22 Deka Products Limited Partnership System and method for printing tissue
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
WO2018100580A1 (en) 2016-12-01 2018-06-07 Regenesis Biomedical Ltd. Method and system for 3d printing
US12297416B2 (en) 2017-07-12 2025-05-13 Deka Products Limited Partneship System and method for transferring tissue
US10570362B2 (en) 2017-07-12 2020-02-25 Deka Products Limited Partnership System and method for transferring tissue
CN107297894A (zh) * 2017-08-11 2017-10-27 江阴司特易生物技术有限公司 一种便携式生物3d打印枪
US11499128B2 (en) 2017-09-22 2022-11-15 The Regents Of The University Of Colorado Organ-on-chip microphysiological system
CN108148754A (zh) * 2018-01-19 2018-06-12 扬州大学 一种3d生物打印双喷头装置
US11679546B2 (en) 2018-02-09 2023-06-20 The Regents Of The University Of Colorado, A Body Corporate Bioprinter and methods of manufacturing an organomimetic device
US11480560B2 (en) 2018-06-11 2022-10-25 The Regents Of The University Of Colorado, A Body Corporate Delivery of aerosolized respiratory pathogens
TWI674201B (zh) * 2018-09-10 2019-10-11 財團法人工業技術研究院 生物材料列印設備
RU2701330C1 (ru) * 2018-11-28 2019-09-25 Частное учреждение Лаборатория биотехнологических исследований "3Д Биопринтинг Солюшенс" (ЧУ"3Д Биопринтинг Солюшенс") Устройство для биопечати одиночными тканевыми сфероидами и используемая в нем печатающая головка
EP3936238A4 (en) * 2019-03-06 2022-11-30 Osaka University METHOD OF PRODUCTION OF CELLULAR TISSUE, SET OF CELLULAR TISSUE AND CELLULAR TISSUE MANUFACTURED BY THIS PRODUCTION PROCESS
EP3946945A4 (en) * 2019-04-04 2023-11-29 Ohio State Innovation Foundation METHOD FOR GENERATIVE MANUFACTURING USING A ROBOT ARM
WO2020231954A1 (en) 2019-05-10 2020-11-19 The University Of North Carolina At Chapel Hill Office Of Technology Commercialization Methods, systems, and computer readable media for generating images of microvasculature using ultrasound
US12296529B2 (en) * 2020-06-09 2025-05-13 3D Systems, Inc. Modular print bed for 3D bioprinter
US12541180B2 (en) 2020-09-04 2026-02-03 International Business Machines Corporation Movement sequence analysis utilizing printed circuits
US20220111579A1 (en) * 2020-10-14 2022-04-14 Applied Materials, Inc. Hybrid printing platform for 3d bioprinting of live organs
US11628069B2 (en) 2020-12-29 2023-04-18 King Abdulaziz University 3D printing of polymeric bioceramics for the treatment of bone defects
CN112920949B (zh) * 2021-01-19 2022-06-14 浙江大学 一种基于dlp的载细胞多材料3d打印系统
US20240253296A1 (en) * 2021-05-11 2024-08-01 Hewlett-Packard Development Company, L.P. Bio-ink printing
RU2770558C2 (ru) * 2021-09-07 2022-04-18 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ радиологии» Минздрава России) Способ создания тканеинженерных конструкций методом биопечати биочернилами для регенерации хрящевой ткани в условиях организма

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5134569A (en) * 1989-06-26 1992-07-28 Masters William E System and method for computer automated manufacturing using fluent material
LU90565B1 (en) * 2000-04-14 2001-10-15 Europ Economic Community Device for the detection of aflatoxins
US8639484B2 (en) 2003-11-14 2014-01-28 Drexel University Method and apparatus for computer-aided tissue engineering for modeling, design and freeform fabrication of tissue scaffolds, constructs, and devices
US8905669B2 (en) * 2004-12-06 2014-12-09 Medhesives, Inc. Dispensing apparatus including an applicator and shield for photocurable resins
US20090263849A1 (en) 2006-04-21 2009-10-22 Drexel University Bioprinting Three-Dimensional Structure Onto Microscale Tissue Analog Devices for Pharmacokinetic Study and Other Uses
FR2901143B1 (fr) 2006-05-16 2008-10-03 Centre Nat Rech Scient "methode de construction de materiaux vivants fonctionnels, materiaux obtenus et applications"
US20080089731A1 (en) * 2006-10-12 2008-04-17 Ezra Szoke Method and apparatus for using dye-diffusion thermal printing
GB0623607D0 (en) * 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
WO2010030964A2 (en) * 2008-09-12 2010-03-18 The Brigham And Women's Hospital, Inc. 3-dimensional multi-layered hydrogels and methods of making the same
EP2384439A4 (en) * 2009-01-30 2013-06-05 Univ Utah Res Found CROSS-LINKED HYDROGELE WITH GOLD NANOPARTICLES
US20120089238A1 (en) * 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
HK1200483A1 (en) * 2011-09-12 2015-08-07 奥加诺沃公司 Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
US9499779B2 (en) * 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
CN103737931B (zh) * 2014-01-06 2017-01-11 上海大学 基于数控铣床的生物3d打印试验平台

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022237003A1 (zh) * 2021-05-14 2022-11-17 清华大学 一种构建复杂异质组织/器官的多级悬浮打印方法

Also Published As

Publication number Publication date
EP3190171A4 (en) 2018-04-18
US20200056147A1 (en) 2020-02-20
US11499135B2 (en) 2022-11-15
US20170198252A1 (en) 2017-07-13
WO2016036275A1 (ru) 2016-03-10
EP3190171A1 (en) 2017-07-12
EA028039B1 (ru) 2017-09-29
US11427802B2 (en) 2022-08-30

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