EA201401082A1 - Фармацевтические препараты, содержащие антагонисты ccr3 - Google Patents
Фармацевтические препараты, содержащие антагонисты ccr3Info
- Publication number
- EA201401082A1 EA201401082A1 EA201401082A EA201401082A EA201401082A1 EA 201401082 A1 EA201401082 A1 EA 201401082A1 EA 201401082 A EA201401082 A EA 201401082A EA 201401082 A EA201401082 A EA 201401082A EA 201401082 A1 EA201401082 A1 EA 201401082A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical preparations
- preparations containing
- alkyl
- ccr3
- containing antagonists
- Prior art date
Links
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 title 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 102000004499 CCR3 Receptors Human genes 0.000 abstract 1
- 108010017316 CCR3 Receptors Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- NTBIYBAYFBNTCD-UHFFFAOYSA-N dibenzoyl 2,3-dihydroxybutanedioate Chemical compound C=1C=CC=CC=1C(=O)OC(=O)C(O)C(O)C(=O)OC(=O)C1=CC=CC=C1 NTBIYBAYFBNTCD-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- Pain & Pain Management (AREA)
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- Oncology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
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- Diabetes (AREA)
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Abstract
В заявке описаны фармацевтические композиции, содержащие соединения формулы (1)в которой Rобозначает Н, C-C-алкил, C-C-алкил-C-C-циклоалкил, C-C-галогеналкил; Rобозначает Н, C-C-алкил; X обозначает анион, выбранный из группы, включающей хлорид или ½ дибензоилтартрат; j равно 1 или 2; способы их приготовления и их применение для лечения заболеваний, связанных с рецептором CCR3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12163078 | 2012-04-04 | ||
| PCT/EP2013/056867 WO2013149987A1 (en) | 2012-04-04 | 2013-04-02 | Pharmaceutical formulations comprising ccr3 antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201401082A1 true EA201401082A1 (ru) | 2015-03-31 |
| EA027627B1 EA027627B1 (ru) | 2017-08-31 |
Family
ID=49292482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201401082A EA027627B1 (ru) | 2012-04-04 | 2013-04-02 | Фармацевтические препараты, содержащие антагонисты ccr3 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US10213421B2 (ru) |
| EP (3) | EP2833864B1 (ru) |
| JP (4) | JP6320990B2 (ru) |
| KR (2) | KR102138709B1 (ru) |
| CN (1) | CN104203213A (ru) |
| AR (1) | AR090596A1 (ru) |
| AU (1) | AU2013245028B2 (ru) |
| BR (1) | BR112014024479A8 (ru) |
| CA (1) | CA2869058C (ru) |
| CL (1) | CL2014002524A1 (ru) |
| CY (1) | CY1121137T1 (ru) |
| DK (2) | DK3524230T3 (ru) |
| EA (1) | EA027627B1 (ru) |
| ES (3) | ES3044310T3 (ru) |
| HR (1) | HRP20190069T1 (ru) |
| HU (2) | HUE056943T2 (ru) |
| IL (1) | IL234299A (ru) |
| IN (1) | IN2014DN07082A (ru) |
| LT (1) | LT2833864T (ru) |
| MX (1) | MX358307B (ru) |
| NZ (1) | NZ628993A (ru) |
| PH (1) | PH12014502241A1 (ru) |
| PL (2) | PL3524230T3 (ru) |
| PT (2) | PT2833864T (ru) |
| RS (1) | RS58360B1 (ru) |
| SI (1) | SI2833864T1 (ru) |
| SM (1) | SMT201900121T1 (ru) |
| TR (1) | TR201821285T4 (ru) |
| TW (1) | TW201400115A (ru) |
| UY (1) | UY34730A (ru) |
| WO (1) | WO2013149987A1 (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| UA109290C2 (uk) | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
| AR090566A1 (es) | 2012-04-02 | 2014-11-19 | Boehringer Ingelheim Int | Proceso para la produccion de inhibidores de crr |
| US20130261153A1 (en) * | 2012-04-03 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Use of ccr3-inhibitors |
| US10213421B2 (en) * | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| ES3046717T3 (en) | 2017-04-05 | 2025-12-02 | Alkahest Inc | Compounds and pharmaceutical compositions for use in treating retina-associated disease using ccr3-inhibitors |
| EP3606525B1 (en) | 2017-04-05 | 2025-12-10 | Alkahest, Inc. | Compositions for treating aging-associated impairments using ccr3-inhibitors |
| CN111343983A (zh) * | 2017-10-13 | 2020-06-26 | 万能溶剂有限公司 | 使用ccr3抑制剂治疗瘙痒、干燥症和相关疾病的方法和组合物 |
| BR112020023001A2 (pt) | 2018-05-15 | 2021-02-02 | Alkahest, Inc. | tratamento de doença associada ao envelhecimento com moduladores da leucotrieno a4 hidrolase |
| JP7528065B2 (ja) * | 2018-09-26 | 2024-08-05 | アルカヘスト，インコーポレイテッド | Ｃｃｒ３阻害剤を用いて、加齢性機能障害を治療するための方法および組成物 |
| CA3180401A1 (en) | 2020-06-11 | 2021-12-16 | Bartosz SIKORSKI | Methods of improving retina-associated disease outcome using ccr3-inhibitors |
| KR20230056017A (ko) | 2020-08-27 | 2023-04-26 | 에이지씨 가부시키가이샤 | 무알칼리 유리 및 유리판 |
| EP4426284A4 (en) | 2021-11-01 | 2025-11-12 | Alkahest Inc | Benzodioxane Leukotriene A4 Hydrolase (LTA4H) Modulators for the Prevention and Treatment of Age-Related Diseases |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7907121L (sv) | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
| US4992277A (en) | 1989-08-25 | 1991-02-12 | Schering Corporation | Immediate release diltiazem formulation |
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