EA202190890A1 - Получение замещенных ароматических соединений и их применение в фармацевтике - Google Patents

Получение замещенных ароматических соединений и их применение в фармацевтике

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Publication number
EA202190890A1
EA202190890A1 EA202190890A EA202190890A EA202190890A1 EA 202190890 A1 EA202190890 A1 EA 202190890A1 EA 202190890 A EA202190890 A EA 202190890A EA 202190890 A EA202190890 A EA 202190890A EA 202190890 A1 EA202190890 A1 EA 202190890A1
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pharmaceuticals
application
aromatic compounds
substituted aromatic
compounds
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EA202190890A
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English (en)
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Туре Шерет
Давид Алан Фразер
Хильде Хермансен Стейнегер
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Басф Ас
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Publication of EA202190890A1 publication Critical patent/EA202190890A1/ru

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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
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    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C59/40—Unsaturated compounds
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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к соединениям общей формулы (I)где R1, R2, R3, R4, R5, R6 и R7 можно выбрать из разных заместителей; n равно 0, 1 или 2; и X означает гидроксиметил или карбоновую кислоту, или ее производное, такое как карбоксилат, такой как эфир карбоновой кислоты, глицерид, ангидрид, фосфолипид, карбоксамид, фосфолипид, или его пролекарство; или фармацевтически приемлемая соль, сольват, сольват такой соли или его пролекарство. Настоящее изобретение также относится к фармацевтическим композициям и липидным композициям, содержащим по меньшей мере одно соединение, предлагаемое в настоящем изобретении, и к таким соединениям для применения в качестве лекарственных средств или для применения в терапии, в частности, для лечения заболеваний, связанных с метаболическими заболеваниями и заболеваниями печени, таких как неалкогольная жировая инфильтрация печени и холестаз.
EA202190890A 2018-10-11 2019-10-10 Получение замещенных ароматических соединений и их применение в фармацевтике EA202190890A1 (ru)

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US201862744461P 2018-10-11 2018-10-11
PCT/IB2019/001139 WO2020074964A1 (en) 2018-10-11 2019-10-10 Romatic compounds and pharmaceutical uses thereof

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EA202190890A1 true EA202190890A1 (ru) 2021-09-10

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US (1) US12473249B2 (ru)
EP (1) EP3864001A1 (ru)
JP (2) JP2022504707A (ru)
KR (1) KR20210091150A (ru)
CN (2) CN120923343A (ru)
AU (2) AU2019358595B2 (ru)
CA (1) CA3112073A1 (ru)
CL (1) CL2021000846A1 (ru)
CO (1) CO2021006087A2 (ru)
EA (1) EA202190890A1 (ru)
IL (1) IL282134A (ru)
MA (1) MA53188A1 (ru)
MX (1) MX2021003750A (ru)
PH (1) PH12021550744A1 (ru)
SG (1) SG11202103011YA (ru)
WO (1) WO2020074964A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023065200A1 (en) * 2021-10-21 2023-04-27 Givaudan Sa Organic compounds
WO2024206117A1 (en) 2023-03-24 2024-10-03 Northsea Therapeutics B.V. Benzoic acid derivatives for use in methods of treating intestinal failure-associated liver disease in children

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
WO1993021912A1 (de) 1992-04-28 1993-11-11 Fresenius Ag Verwendung einer omega-3-fettsäuren enthaltenden emulsion zur herstellung eines parenteral zu verabreichenden arzneimittels zur behandlung von entzündlichen erkrankungen
ES2295397T3 (es) 2001-04-18 2008-04-16 Prometic Biosciences Inc. Acidos grasos como factores de supervivencia y activacion de neutrofilos.
KR100965201B1 (ko) 2001-06-12 2010-06-24 웰스테트 테라퓨틱스 코포레이션 대사 질환의 치료용 화합물
US7553867B2 (en) * 2002-09-06 2009-06-30 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
WO2004069782A2 (en) * 2003-02-06 2004-08-19 Dompe' S.P.A. 2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them
EP1592416B1 (en) 2003-02-07 2009-01-07 ProMetic BioSciences Inc. Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis
ES2530235T3 (es) * 2003-02-13 2015-02-27 Wellstat Therapeutics Corporation Compuestos para el tratamiento de trastornos metabólicos
KR101120813B1 (ko) 2003-07-25 2012-03-23 프로메틱 바이오사이언시즈 인코포레이티드 중-쇄 지방산 금속염의 제조 방법
ES2372694T3 (es) * 2003-10-15 2012-01-25 OSI Pharmaceuticals, LLC Inhibidores de tirosina cinasa de imidazo[1,5-a]pirazina.
CA2547547A1 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
KR20070063507A (ko) 2004-09-03 2007-06-19 프로메틱 바이오사이언시즈 인코포레이티드 면역조절작용과 화학방어활성을 가진 치환된 퓨리닐 유도체및 단독 또는 중쇄 길이 지방산이나 글리세리드와의 혼합사용
US8071580B2 (en) 2004-10-01 2011-12-06 Prometic Biosciences Inc. Medium-chain length fatty alcohols as stimulators of hematopoiesis
CA2582262C (en) 2004-10-01 2013-01-08 Prometic Biosciences Inc. Medium-chain length fatty alcohols as stimulators of hematopoiesis
EP1836160A1 (en) * 2004-12-24 2007-09-26 CTG Pharma S.r.l. Compounds for treating metabolic syndrome
TW200724138A (en) * 2005-03-29 2007-07-01 Sk Corp Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use
JP2008543741A (ja) * 2005-05-09 2008-12-04 アストラゼネカ・アクチエボラーグ 新規な化合物
GB0522433D0 (en) * 2005-11-03 2005-12-14 Astrazeneca Ab Therapeutic agents
AU2007214709A1 (en) * 2006-02-15 2007-08-23 Sanofi-Aventis Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
JP5301272B2 (ja) * 2006-07-31 2013-09-25 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 メタロ−β−ラクタマーゼ阻害剤
EP2136624A4 (en) * 2007-03-21 2011-11-30 Emisphere Tech Inc DISPENSER FOR ALLYLOXY- AND ALKYLOXYBENZOIC ACID
EP2155711A1 (en) 2007-06-05 2010-02-24 Sanofi-Aventis Substituted benzoylamino-indan-2-carboxylic acids and related compounds
KR101601987B1 (ko) 2007-11-02 2016-03-09 프로메틱 바이오사이언시즈 인코포레이티드 신장 보호제로서 중쇄 길이 지방산 및 글리세라이드
TWI448290B (zh) 2007-12-19 2014-08-11 Prometic Biosciences Inc 與健擇他濱（ｇｅｍｃｉｔａｂｉｎｅ）組合用於胰臟癌之治療的中等鏈長脂肪酸、鹽類及三酸甘油酯
JP2011517321A (ja) * 2008-03-13 2011-06-02 ビーエーエスエフ ソシエタス・ヨーロピア 二量体ベンジリデンマロネート類
CN102088965B (zh) * 2008-05-13 2013-05-08 根梅迪卡治疗公司 水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用
WO2010012650A1 (en) * 2008-07-28 2010-02-04 Syddansk Universitet Compounds for the treatment of metabolic diseases
MX2011011757A (es) 2009-05-04 2012-01-25 Prometic Biosciences Inc Compuestos aromaticos substituidos y usos farmaceuticos.
JP5843755B2 (ja) * 2009-05-08 2016-01-13 プロノヴァ・バイオファーマ・ノルゲ・アーエスＰｒｏｎｏｖａ ＢｉｏＰｈａｒｍａ Ｎｏｒｇｅ ＡＳ 心血管性、代謝性および炎症性疾患領域に関する疾患の処置のための多価不飽和脂肪酸
NZ598907A (en) * 2009-10-20 2014-03-28 Cellzome Ltd Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors
AU2010323066B2 (en) * 2009-11-26 2014-12-11 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
TWI572352B (zh) 2012-03-01 2017-03-01 波麥堤克藥學Ｓｍｔ有限公司 用於製備具中鏈長度之脂肪酸的三酸甘油酯之方法
US9562041B2 (en) * 2012-05-16 2017-02-07 Glaxosmithkline Llc Enhancer of zeste homolog 2 inhibitors
TWI689489B (zh) 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
TWI689490B (zh) 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療纖維化之經取代之芳族化合物及相關方法
WO2015179697A1 (en) * 2014-05-21 2015-11-26 Taxis Pharmaceuticals, Inc. Compounds for the treatment of bacterial infections
AU2015330643B2 (en) 2014-10-10 2020-05-14 Liminal Biosciences Limited Substituted aromatic compounds and pharmaceutical compositions for the prevention and treatment of diabetes
GB2543478A (en) * 2015-09-07 2017-04-26 Manchester Metropolitan Univ Glycomimetics
CN118084809A (zh) 2018-05-08 2024-05-28 株式会社艾迪科 化合物、潜伏性添加剂、组合物、固化物、固化物的制造方法及组合物的制造方法

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