ECSP003580A - NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8 - Google Patents
NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8Info
- Publication number
- ECSP003580A ECSP003580A ECSP003580A ECSP003580A EC SP003580 A ECSP003580 A EC SP003580A EC SP003580 A ECSP003580 A EC SP003580A EC SP003580 A ECSP003580 A EC SP003580A
- Authority
- EC
- Ecuador
- Prior art keywords
- gdf
- methods
- analogs
- vaccination
- homologous
- Prior art date
Links
- 102000004472 Myostatin Human genes 0.000 title abstract 11
- 108010056852 Myostatin Proteins 0.000 title abstract 11
- 238000000034 method Methods 0.000 title abstract 7
- 230000003053 immunization Effects 0.000 title abstract 3
- 238000002649 immunization Methods 0.000 title abstract 3
- 210000003205 muscle Anatomy 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 abstract 3
- 238000002255 vaccination Methods 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se revelan métodos nuevos para aumentar la masa muscular mediante la inmunización contra el factor de diferenciación de crecimiento 8 (GDF-8, miostatina). La inmunización se efectua preferentemente mediante la administración de análogos de GDF-8 capaces de inducir la producción de anticuerpos contra GDF-8 homólogos. Se prefiere especialmente como un inmunógeno el GDF-8 homólogo modificado por la introducción de un solo o varios, epitopes de célula T extraños inmunodominantes y promiscuos a la vez que se conserva sustancialmente la estructura terciaria del GDF-8 homólogo. También se presenta la vacunación de ácido nucleico contra GDF-8 y la vacunación usando vacunas vivas, como asi también métodos y medios útiles para la vacunación. Dichos métodos y medios incluyen métodos para la identificación de análogos de GDF-8 inmunogénicos, métodos para la preparación de análogos de GDF-8 inmunogénicos, métodos para la preparación de análogos y formulaciones farmacéuticas como asi también fragmentos de ácido nucleico, vectores, células transformadas polipéptidos y formulaciones farmacéuticas.Novel methods of increasing muscle mass are revealed by immunization against growth differentiation factor 8 (GDF-8, myostatin). Immunization is preferably effected by administration of GDF-8 analogs capable of inducing the production of antibodies against homologous GDF-8. Especially preferred as an immunogen is homologous GDF-8 modified by the introduction of one or more, immunodominant and promiscuous foreign T-cell epitopes while substantially conserving the tertiary structure of the homologous GDF-8. Nucleic acid vaccination against GDF-8 and vaccination using live vaccines are also presented, as well as useful methods and means for vaccination. Such methods and means include methods for the identification of immunogenic GDF-8 analogs, methods for the preparation of immunogenic GDF-8 analogs, methods for the preparation of analogues and pharmaceutical formulations as well as nucleic acid fragments, vectors, transformed cells. polypeptides and pharmaceutical formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003580 ECSP003580A (en) | 2000-07-20 | 2000-07-20 | NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003580 ECSP003580A (en) | 2000-07-20 | 2000-07-20 | NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003580A true ECSP003580A (en) | 2000-10-24 |
Family
ID=42041192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003580 ECSP003580A (en) | 2000-07-20 | 2000-07-20 | NEW METHODS TO INCREASE MUSCLE MASS THROUGH IMMUNIZATION AGAINST GDF-8 |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003580A (en) |
-
2000
- 2000-07-20 EC ECSP003580 patent/ECSP003580A/en unknown
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