ECSP003580A - Metodos nuevos para aumentar la masa muscular mediante la inmunizacion contra el gdf-8 - Google Patents
Metodos nuevos para aumentar la masa muscular mediante la inmunizacion contra el gdf-8Info
- Publication number
- ECSP003580A ECSP003580A ECSP003580A ECSP003580A EC SP003580 A ECSP003580 A EC SP003580A EC SP003580 A ECSP003580 A EC SP003580A EC SP003580 A ECSP003580 A EC SP003580A
- Authority
- EC
- Ecuador
- Prior art keywords
- gdf
- methods
- analogs
- vaccination
- homologous
- Prior art date
Links
- 102000004472 Myostatin Human genes 0.000 title abstract 11
- 108010056852 Myostatin Proteins 0.000 title abstract 11
- 238000000034 method Methods 0.000 title abstract 7
- 230000003053 immunization Effects 0.000 title abstract 3
- 238000002649 immunization Methods 0.000 title abstract 3
- 210000003205 muscle Anatomy 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 abstract 3
- 238000002255 vaccination Methods 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se revelan métodos nuevos para aumentar la masa muscular mediante la inmunización contra el factor de diferenciación de crecimiento 8 (GDF-8, miostatina). La inmunización se efectua preferentemente mediante la administración de análogos de GDF-8 capaces de inducir la producción de anticuerpos contra GDF-8 homólogos. Se prefiere especialmente como un inmunógeno el GDF-8 homólogo modificado por la introducción de un solo o varios, epitopes de célula T extraños inmunodominantes y promiscuos a la vez que se conserva sustancialmente la estructura terciaria del GDF-8 homólogo. También se presenta la vacunación de ácido nucleico contra GDF-8 y la vacunación usando vacunas vivas, como asi también métodos y medios útiles para la vacunación. Dichos métodos y medios incluyen métodos para la identificación de análogos de GDF-8 inmunogénicos, métodos para la preparación de análogos de GDF-8 inmunogénicos, métodos para la preparación de análogos y formulaciones farmacéuticas como asi también fragmentos de ácido nucleico, vectores, células transformadas polipéptidos y formulaciones farmacéuticas.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003580 ECSP003580A (es) | 2000-07-20 | 2000-07-20 | Metodos nuevos para aumentar la masa muscular mediante la inmunizacion contra el gdf-8 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003580 ECSP003580A (es) | 2000-07-20 | 2000-07-20 | Metodos nuevos para aumentar la masa muscular mediante la inmunizacion contra el gdf-8 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003580A true ECSP003580A (es) | 2000-10-24 |
Family
ID=42041192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003580 ECSP003580A (es) | 2000-07-20 | 2000-07-20 | Metodos nuevos para aumentar la masa muscular mediante la inmunizacion contra el gdf-8 |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003580A (es) |
-
2000
- 2000-07-20 EC ECSP003580 patent/ECSP003580A/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2001005820A3 (en) | Method for down-regulating gdf-8 activity | |
| GC0000355A (en) | Novel method for down-regulation of amyloid | |
| Baker et al. | Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine | |
| ES2265148T3 (es) | Enterotoxina mutante eficaz como adyuvante oral no toxico. | |
| BR0212047A (pt) | Uso de imunogene, poliaminoácido ou conjugado, composição imunogênica, fragmento de ácido nucleico, vetor, célula transformada, composição para induzir a produção de anticorpos contra amilóide, e, linhagem de célula estável | |
| Conlan et al. | Immunization of mice with lipopeptide antigens encapsulated in novel liposomes prepared from the polar lipids of various Archaeobacteria elicits rapid and prolonged specific protective immunity against infection with the facultative intracellular pathogen, Listeria monocytogenes | |
| Zadeh-Vakili et al. | Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis | |
| Wang et al. | Improved immunogenicity of a tuberculosis DNA vaccine encoding ESAT6 by DNA priming and protein boosting | |
| US20220281907A1 (en) | Modified hexa-acylated neisserial LPS | |
| Xu et al. | Efficacy of a DNA vaccine carrying Eimeria maxima Gam56 antigen gene against coccidiosis in chickens | |
| NO301577B1 (no) | Fremgangsmåte for fremstilling av en stabil vaksineblanding og fremgangsmåte for stabilisering av interleukin i en vaksineblanding | |
| WO1992005192A1 (en) | T-cell epitopes | |
| US11389520B2 (en) | Modified tetra-acylated neisserial LPS | |
| TW201925240A (zh) | 肽共軛物、共軛過程及其用途 | |
| ES2375053T3 (es) | Péptido derivado de la interleucina-1-beta y su aplicación terapéutica. | |
| Levine et al. | Clinical and field trials with attenuated Salmonella typhi as live oral vaccines and as “carrier” vaccines | |
| US9534020B2 (en) | Immunogenic polypeptides comprising a modified loop peptide presenting the HIV-1 GP120 3074 mAb epitope and scaffold proteins containing said peptide | |
| AR024808A1 (es) | Metodo para aumentar la masa muscular mediante la inmunizacion contra el factor de diferenciacion de crecimiento 8 (gdf-8, miostatina) | |
| CN103189386B (zh) | 重组人类免疫缺陷病毒（hiv）包膜抗原蛋白和含其的疫苗 | |
| Zhou et al. | Augmented humoral and cellular immune response of hepatitis B virus DNA vaccine by micro-needle vaccination using Flt3L as an adjuvant | |
| Kanoi et al. | New concepts in vaccine development in malaria | |
| DE3064590D1 (en) | Process for the preparation of influenza a virus vaccinating strains, vaccinating strain and vaccine containing it | |
| PT2256185E (pt) | Protecção heteróloga contra pasteurella multocida provida por células de p. multocida fur e seus extractos proteicos de membrana externa | |
| ES2336684T3 (es) | Vacunas de subunidades de ornithobacterium rhinotracheale. | |
| WO2022055375A1 (es) | Vacuna viva recombinante para sars-cov-2 basada en salmonella enteritidis recombinante |