ECSP003672A - SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES - Google Patents
SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USESInfo
- Publication number
- ECSP003672A ECSP003672A ECSP003672A ECSP003672A EC SP003672 A ECSP003672 A EC SP003672A EC SP003672 A ECSP003672 A EC SP003672A EC SP003672 A ECSP003672 A EC SP003672A
- Authority
- EC
- Ecuador
- Prior art keywords
- app
- secretase
- alzheimer
- disease
- substrates
- Prior art date
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title abstract 2
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000000758 substrate Substances 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Enzymes And Modification Thereof (AREA)
Abstract
La presente invención proporciona la enzima y los procedimientos enzimáticos para escindir el sitio de escición de a-secretasa de la proteína APP, y los correspondientes ácidos nucleicos, péptidos, vectores, células y aislados celulares y ensayos. También se proporciona una enzima que corta el sitio a-secretasa de APP. La invención además proporciona una proteína APP modificada y sus correspondientes ácidos nucleicos, péptidos, vectores, células y aislados celulares, y ensayos que son esencialmente útiles para identificar sustancias potencialmente terapéuticas en el tratamiento o la prevención de la enfermedad de Alzheimer.The present invention provides the enzyme and enzymatic methods for cleaving the a-secretase cleavage site of the APP protein, and the corresponding nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cuts the APP-secretase site of APP is also provided. The invention further provides a modified APP protein and its corresponding nucleic acids, peptides, vectors, cells and cell isolates, and assays that are essentially useful for identifying potentially therapeutic substances in the treatment or prevention of Alzheimer's disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003672 ECSP003672A (en) | 2000-09-22 | 2000-09-22 | SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003672 ECSP003672A (en) | 2000-09-22 | 2000-09-22 | SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003672A true ECSP003672A (en) | 2001-04-23 |
Family
ID=42041266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003672 ECSP003672A (en) | 2000-09-22 | 2000-09-22 | SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003672A (en) |
-
2000
- 2000-09-22 EC ECSP003672 patent/ECSP003672A/en unknown
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