ECSP003740A - POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST - Google Patents
POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONISTInfo
- Publication number
- ECSP003740A ECSP003740A ECSP003740A ECSP003740A EC SP003740 A ECSP003740 A EC SP003740A EC SP003740 A ECSP003740 A EC SP003740A EC SP003740 A ECSP003740 A EC SP003740A
- Authority
- EC
- Ecuador
- Prior art keywords
- methyl
- receptor antagonist
- tachyquinine
- polymorphic form
- triazol
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- RXXYJBUUGPAHIJ-LLVKDONJSA-N (3s)-3-(4-fluorophenyl)-4-methylmorpholine Chemical compound CN1CCOC[C@@H]1C1=CC=C(F)C=C1 RXXYJBUUGPAHIJ-LLVKDONJSA-N 0.000 abstract 1
- XEAXFXBFMWAHDJ-VIISRWQNSA-N Cl.C[C@@H](O[C@H]1OCCN(c2nn[nH]c2CN(C)C)[C@@]1(C)c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F Chemical compound Cl.C[C@@H](O[C@H]1OCCN(c2nn[nH]c2CN(C)C)[C@@]1(C)c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F XEAXFXBFMWAHDJ-VIISRWQNSA-N 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- -1 hydrochloride compound Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000002462 tachykinin receptor antagonist Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención tiene que ver con nuevas formas polimórficas del compuesto hidroclorato 2-®-(1-®-(3,5-bis(trifluorometil)-fenil)-etoxi)-4-(5-(dimetil-amino)metil-1,2,3-triazol-4-il)metil-3-(S)-(4-fluorofenil) morfolina, el cual es un antagonista de recptor de taquiquinina útil en el tratamiento o prevención de trastornos del sistema nervioso central, enfermedades inflamatorias, dolor o migraña, asma y emesis. Las presente formas polimórficas, tiene ventajas sobre las otras formas conocidas de hidroclorato 2-(R)-(1-(R)-(3,5-bis(trifluorometil)-fenil)-etoxi)-4-(5-(dimetil-amino)metil-1,2,3-triazol-4-il) metil-3-(S)-(4-fluorofenil)morfolina, en términos de estabilidad termodinámica e idoneidad para su inclusión en formulaciones farmacéuticas.This invention relates to novel polymorphic forms of the hydrochloride compound 2-®- (1-®- (3,5-bis (trifluoromethyl) -phenyl) -ethoxy) -4- (5- (dimethyl-amino) methyl-1 2,3-triazol-4-yl) methyl-3- (S) - (4-fluorophenyl) morpholine, which is a tachykinin receptor antagonist useful in the treatment or prevention of disorders of the central nervous system, inflammatory diseases , pain or migraine, asthma and emesis. The present polymorphic forms have advantages over the other known forms of hydrochloride 2- (R) - (1- (R) - (3,5-bis (trifluoromethyl) -phenyl) -ethoxy) -4- (5- (dimethyl -amino) methyl-1,2,3-triazol-4-yl) methyl-3- (S) - (4-fluorophenyl) morpholine, in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003740 ECSP003740A (en) | 2000-10-27 | 2000-10-27 | POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP003740 ECSP003740A (en) | 2000-10-27 | 2000-10-27 | POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP003740A true ECSP003740A (en) | 2000-12-19 |
Family
ID=42041316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP003740 ECSP003740A (en) | 2000-10-27 | 2000-10-27 | POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP003740A (en) |
-
2000
- 2000-10-27 EC ECSP003740 patent/ECSP003740A/en unknown
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