MY126509A - Polymorphic form of a tachykinin receptor antagonist - Google Patents

Polymorphic form of a tachykinin receptor antagonist

Info

Publication number
MY126509A
MY126509A MYPI98003007A MYPI19983007A MY126509A MY 126509 A MY126509 A MY 126509A MY PI98003007 A MYPI98003007 A MY PI98003007A MY PI19983007 A MYPI19983007 A MY PI19983007A MY 126509 A MY126509 A MY 126509A
Authority
MY
Malaysia
Prior art keywords
phenyl
receptor antagonist
polymorphic form
tachykinin receptor
triazolo
Prior art date
Application number
MYPI98003007A
Inventor
Crocker Louis
Mccauley James
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MY126509A publication Critical patent/MY126509A/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

THIS INVENTION IS CONCERNED WITH A NOVEL POLYMORPHIC FORM OF THE COMPOUND 2-(R)-(1-(R)-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)-ETHOXY)-3-(S)-(4-FLUORO) PHENYL-4-(3-(5-OXO-1H,4H-1,2,4-TRIAZOLO) METHYLMORPHOLINE WHICH IS A TACHYKININ RECEPTOR ANTAGONIST USEFUL IN THE TREATMENT OR PREVENTION OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM, INFLAMMATORY DISEASES, PAIN OR MIGRAINE, ASTHMA, AND EMESIS. THE INSTANT POLYMORPHIC FROM HAS ADVANTAGES OVER THE OTHER KNOWN FORMS OF 2-(R)-(1-(R)-3,5-BIS(TRIFLUORO-METHYL)- PHENYL) ETHOXY)-3-(S)-(4-FLUORO) PHENYL-4-(3-(5-OXO-1H,4H-1,2,4-TRIAZOLO) METHYLMORPHOLINE IN TERMS OF THERMODYNAMIC STABILITY AND SUITABILITY FOR INCLUSION IN PHARMACEUTICAL FORMULATIONS.(FIG. 1)
MYPI98003007A 1997-07-02 1998-07-01 Polymorphic form of a tachykinin receptor antagonist MY126509A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5160097P 1997-07-02 1997-07-02
GBGB9800216.5A GB9800216D0 (en) 1998-01-07 1998-01-07 Polymorphic form of a tachykinin receptor antagonist

Publications (1)

Publication Number Publication Date
MY126509A true MY126509A (en) 2006-10-31

Family

ID=10824888

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI98003007A MY126509A (en) 1997-07-02 1998-07-01 Polymorphic form of a tachykinin receptor antagonist

Country Status (6)

Country Link
AR (1) AR013160A1 (en)
CO (1) CO4940431A1 (en)
GB (1) GB9800216D0 (en)
MY (1) MY126509A (en)
RS (1) RS49980B (en)
UA (1) UA57089C2 (en)

Also Published As

Publication number Publication date
AR013160A1 (en) 2000-12-13
CO4940431A1 (en) 2000-07-24
UA57089C2 (en) 2003-06-16
RS49980B (en) 2008-09-29
GB9800216D0 (en) 1998-03-04

Similar Documents

Publication Publication Date Title
ZA985765B (en) Polymorphic form of a tachykinin receptor antagonist.
DE69838421D1 (en) Polymorphe form des tachykininrezeptorantagonisten 2-(r)-(1-(r)-(3,5-bis(trifluormethyl)phenyl)ethoxy)-3-(s)-(4-fluor)phenyl-4-(3-5-oxo-1h,4h-1,2,4-triazolo)methylmorpholin
JO3060B1 (en) Pharmaceutical composition of a techykinin receptor antagonist
IL114474A (en) (R)-(3)-3-(1H-indol-3-yl)-1-[N-(2-methoxybenzyl)acetylamino]-2-[N-(2-(4-piperidin-1-yl)piperidin-1-yl acetyl)amino]propane dihydrochloride trihydrate and tachykinin receptor antagonistic pharmaceutical compositions containing it
HRP20020973A2 (en) Process for the synthesis of (2r,2-alpha-r,3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
NO20045001L (en) Process for Preparation of 5 - [[2 (R) - [1 (R) - [3,5-Bis (trifluoromethyl) phenyl] ethoxy] -3 (S) - (4-fluorophenyl) -4-morpholinyl] methyl] -1,2-dihydro-3H-1,2,4-triazol-3-one
WO2002034699A3 (en) Mammalian metabolites of a tachykinin receptor antagonist
AU2001269749A1 (en) Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine
AR026288A1 (en) POLYMORPHIC FORM OF AN TAQUICININE RECEIVER ANTAGONIST
AR013160A1 (en) POLYMORPHIC FORM OF AN ANTAGONIST RECEIVER OF TACHYQUININE, PHARMACEUTICAL COMPOSITION, USE OF THE SAME FOR THE PREPARATION OF MEDICINES.
NO993372D0 (en) Substituted 4- (6-fluoro- (1H) -indol-3-yl) -1,2,3,6-tetrahydropyridine for the treatment of CNS disorders
WO2002024727A3 (en) New inhibitors of iapp fibril formation and uses thereof
ECSP982575A (en) POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST
TH17690B (en) The polymorphic form of the tachikinin receptor antagonist.
TH47996A (en) The polymorphic form of the tachikinin receptor antagonist.
BR9810360A (en) Polymorphic form of compound 2- (r) - (1- (r) - (3,5-bis (tri-fluoromethyl) phenyl) ethoxy) -3- (s) - (4-fluoro) phenyl-4 (3- (5-oxo-1h, 4h-1,2,4-triazolo) methylmorpholine, process for preparing form 1 thereof, pharmaceutical composition, process for antagonizing the effect of substance p on its receptor site or for blocking the receptors of neurokinin-1 in a mammal, processes to treat or prevent a selected condition, emesis, a central nervous system disorder, depression, anxiety, and schizophrenia in a mammal, and product
ECSP003740A (en) POLYMORPHIC FORM OF A TACHYQUININE RECEPTOR ANTAGONIST
AU2001268290A1 (en) Intramolecular glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-(1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)-1,4-oxazine
MX9700960A (en) PROCEDURES AND INTERMEDIATES IN THE SYNTHESIS OF 5- (3- [EXOBICICLO [2.2.I] HEPT-2-ILOXI] -4-METOXIFENIL) -3,4,5,6-TETRAHIDROPIRIMIDIN-2 (IH) -ONA.