ECSP003807A - Composiciones valdecoxib - Google Patents

Composiciones valdecoxib

Info

Publication number
ECSP003807A
ECSP003807A EC2000003807A ECSP003807A ECSP003807A EC SP003807 A ECSP003807 A EC SP003807A EC 2000003807 A EC2000003807 A EC 2000003807A EC SP003807 A ECSP003807 A EC SP003807A EC SP003807 A ECSP003807 A EC SP003807A
Authority
EC
Ecuador
Prior art keywords
compositions
valdecoxib
valdecoxib compositions
cyclooxygenase
prophylaxis
Prior art date
Application number
EC2000003807A
Other languages
English (en)
Inventor
Sreekant Nadkarni
Mark J Kontny
Tugrul Kararli
Subhash Desai
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of ECSP003807A publication Critical patent/ECSP003807A/es

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Classifications

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K9/51—Nanocapsules; Nanoparticles
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Abstract

Se proporcionan las composiciones farmacéuticas que comprenden valdecoxib particulado en una cantidad de aproximadamente 1 mg a aproximadamente 100 mg y uno o más excipientes farmacéuticamente aceptables. Las composiciones son útiles en el tratamiento o profilaxis de las condiciones o desórdenes mediados por ciclooxígenasa-2.
EC2000003807A 1999-12-08 2000-12-04 Composiciones valdecoxib ECSP003807A (es)

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US16985699P 1999-12-08 1999-12-08

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ECSP003807A true ECSP003807A (es) 2005-07-06

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EC2000003807A ECSP003807A (es) 1999-12-08 2000-12-04 Composiciones valdecoxib

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AR (2) AR027897A1 (es)
AU (1) AU2041201A (es)
BG (1) BG65239B1 (es)
CO (1) CO5251445A1 (es)
CZ (1) CZ20012875A3 (es)
EA (1) EA200401397A1 (es)
EC (1) ECSP003807A (es)
ES (1) ES2236011T3 (es)
HU (1) HUP0200580A3 (es)
MY (2) MY128971A (es)
NZ (1) NZ529933A (es)
OA (1) OA11831A (es)
PE (1) PE20010911A1 (es)
PT (2) PT1150960E (es)
SV (1) SV2002000235A (es)
TW (1) TWI276435B (es)
WO (1) WO2001041536A2 (es)
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Families Citing this family (21)

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NZ524252A (en) 2000-07-20 2004-03-26 Lauras As Cox-2 inhibitors for treating HIV and AIDS
MXPA03011784A (es) 2001-06-22 2004-04-02 Pfizer Prod Inc Composiciones farmaceuticas de dispersiones de farmacos y polimeros neutros.
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
WO2004061433A1 (en) * 2002-12-30 2004-07-22 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
IL163846A0 (en) 2002-03-01 2005-12-18 Univ South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
BR0309913A (pt) * 2002-05-13 2005-06-07 Pharmacia Corp Compósito estável de celecoxib amorfo e processo para fabricar o mesmo
EP1511490A4 (en) 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
IL165383A0 (en) * 2002-06-21 2006-01-15 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution
US20060052432A1 (en) * 2002-09-20 2006-03-09 Julius Remenar Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
AU2003303591A1 (en) * 2002-12-30 2004-07-29 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
BRPI0508063A (pt) * 2004-06-29 2007-07-17 Nycomed Danmark Aps processo para a manufatura de uma composição farmacêutica, nsaid, e, composição farmacêutica
GB0423103D0 (en) * 2004-10-19 2004-11-17 Boots Healthcare Int Ltd Therapeutic agents
US20080171746A1 (en) * 2005-03-14 2008-07-17 Thomas Klein Method for Preventing Cardiovascular Diseases
CN103462920A (zh) * 2012-06-06 2013-12-25 南京亿华药业有限公司 一种口服环加氧酶-2抑制剂塞来昔布的组合物
CN103524416B (zh) * 2013-10-29 2016-08-17 湖北华世通生物医药科技有限公司 一种塞来昔布新晶型a及其制备方法
CN103508958A (zh) * 2013-10-30 2014-01-15 中美华世通生物医药科技(武汉)有限公司 一种塞来昔布新晶型c及其制备方法
CN103539739B (zh) * 2013-10-30 2016-02-10 中美华世通生物医药科技(武汉)有限公司 一种塞来昔布新晶型b及其制备方法
KR101476096B1 (ko) * 2014-03-28 2014-12-24 대원제약주식회사 용해도가 향상된 쎄레콕시브의 약제학적 조성물

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Publication number Priority date Publication date Assignee Title
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
CA2277954A1 (en) * 1993-11-30 1995-06-08 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
JP3267300B2 (ja) * 1995-02-13 2002-03-18 ジー.ディー.サール アンド カンパニー 炎症の治療のための置換イソオキサゾール
US5633272A (en) * 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US5756529A (en) * 1995-09-29 1998-05-26 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
US5981576A (en) * 1995-10-13 1999-11-09 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
EP0863134A1 (en) * 1997-03-07 1998-09-09 Merck Frosst Canada Inc. 2-(3,5-difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2
AU3762699A (en) * 1998-04-27 1999-11-16 Pacific Northwest Cancer Foundation (nr-cam) gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors

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EA200401397A1 (ru) 2005-08-25
MY128971A (en) 2007-03-30
CZ20012875A3 (cs) 2002-02-13
OA11831A (en) 2005-08-23
CN1216869C (zh) 2005-08-31
PT1150960E (pt) 2005-06-30
PE20010911A1 (es) 2001-09-10
BG105808A (en) 2002-09-30
ZA200107146B (en) 2002-08-29
KR20020002386A (ko) 2002-01-09
AU2041201A (en) 2001-06-18
HUP0200580A2 (hu) 2002-11-28
AR030039A1 (es) 2003-08-13
YU57801A (sh) 2005-07-19
CN1411447A (zh) 2003-04-16
SV2002000235A (es) 2002-06-13
NZ529933A (en) 2005-06-24
ES2236011T3 (es) 2005-07-16
MY128366A (en) 2007-01-31
KR100717570B1 (ko) 2007-05-15
WO2001041536A2 (en) 2001-06-14
PT1150959E (pt) 2008-04-21
HUP0200580A3 (en) 2002-12-28
TWI276435B (en) 2007-03-21
CO5251445A1 (es) 2003-02-28
AR027897A1 (es) 2003-04-16
ZA200107149B (en) 2003-02-28
BG65239B1 (bg) 2007-09-28

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