ECSP034495A - PHENOXIBENCILAMINE DERIVATIVES AS SSRI - Google Patents

PHENOXIBENCILAMINE DERIVATIVES AS SSRI

Info

Publication number
ECSP034495A
ECSP034495A ECSP034495A ECSP034495A EC SP034495 A ECSP034495 A EC SP034495A EC SP034495 A ECSP034495 A EC SP034495A EC SP034495 A ECSP034495 A EC SP034495A
Authority
EC
Ecuador
Prior art keywords
alkyl
heterocyclic ring
alkoxy
nitrogen
independently
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Harry Ralph Howard
David Hepworth
Alan Stobie
Donald Stuart Middleton
Mark L Elliott
Mark David Andrews
Mavis Diane Adam
Geoffrey Edward Gymer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP034495A publication Critical patent/ECSP034495A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de fórmula general (I) en la que R1 y R2, son H alquilo C1-C6 o (CH2)d-(cicloalquilo C3-C6), donde d es 0, 1, 2, ó 3; o R1 y R2 junto con el nitrógeno al que estén unidos forman un anillo de azetidina; uno de Z o Y es -SR3 y el otro de Z o Y es halógeno o R3; donde R3 es independientemente alquilo C1-C4 opcionalmente sustituido con flúor; excepto que R3 no es CF3 o Z e Y están unidos de manera que junto con los átomos de interconexíon Z e Y forman un anillo carbocíclico o heterocíclico de 5 a 7 miembros, condensado y donde cuando Z e Y forman un anillo heterocíclico, además de átomos de carbono, el enlace contiene uno o dos heteroátomos seleccionados independientemente entre oxígeno azufre y nitrógeno; R4 y R5, que pueden ser iguales o diferentes son: A-X donde A es -CH-CH- o - (CH2)p-, donde p es 0, 1 ó 2; X es hidrógeno F, CI, Br, I CONR6R7, SO2NR6R7, SO2NHC(-0)R6. OH alcoxi C1-4. NR8SO2R9, NO2, NR6R11. CN. CO2R10, CHO, SR10, S(O)R9 o SO2R10; o un anillo heterocíclico de 5 a 6 miembros que contiene 1, 2 o 3 heteroátomos seleccionados entre N, S y O opcionalmente sustituidos independientemente con uno o más R13; donde R13 es hidroxi, alcoxi C1-C4, F, alquilo C1-C6, haloalquilo, haloalcoxi, -NH2, -NH(alquiloC1-c6) o -N(alquiloC1-C6)2.A compound of general formula (I) in which R1 and R2 are H C1-C6 alkyl or (CH2) d- (C3-C6 cycloalkyl), where d is 0, 1, 2, or 3; or R1 and R2 together with the nitrogen to which they are attached form an azetidine ring; one of Z or Y is -SR3 and the other of Z or Y is halogen or R3; where R3 is independently C1-C4 alkyl optionally substituted with fluorine; except that R3 is not CF3 or Z and Y are attached so that together with the interconnection atoms Z and Y form a 5- to 7-membered carbocyclic or heterocyclic ring, and where when Z and Y form a heterocyclic ring, in addition to carbon atoms, the bond contains one or two heteroatoms independently selected from sulfur oxygen and nitrogen; R4 and R5, which may be the same or different are: A-X where A is -CH-CH- or - (CH2) p-, where p is 0, 1 or 2; X is hydrogen F, CI, Br, I CONR6R7, SO2NR6R7, SO2NHC (-0) R6. OH C1-4 alkoxy. NR8SO2R9, NO2, NR6R11. CN CO2R10, CHO, SR10, S (O) R9 or SO2R10; or a 5- to 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O optionally independently substituted with one or more R13; where R13 is hydroxy, C1-C4 alkoxy, F, C1-C6 alkyl, haloalkyl, haloalkoxy, -NH2, -NH (C1-C6 alkyl) or -N (C1-C6 alkyl) 2.

ECSP034495 2000-08-31 2003-02-27 PHENOXIBENCILAMINE DERIVATIVES AS SSRI ECSP034495A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0021593A GB0021593D0 (en) 2000-08-31 2000-08-31 Diphenyl ether compounds useful in therapy

Publications (1)

Publication Number Publication Date
ECSP034495A true ECSP034495A (en) 2003-04-25

Family

ID=9898741

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP034495 ECSP034495A (en) 2000-08-31 2003-02-27 PHENOXIBENCILAMINE DERIVATIVES AS SSRI

Country Status (4)

Country Link
EC (1) ECSP034495A (en)
GB (1) GB0021593D0 (en)
PY (1) PY0121416A (en)
ZA (1) ZA200301383B (en)

Also Published As

Publication number Publication date
PY0121416A (en) 2004-06-01
GB0021593D0 (en) 2000-10-18
ZA200301383B (en) 2004-04-02

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