ECSP034524A - Derivados de pirina con actividad inhibidora de quinasa ikb (ikk-beta) - Google Patents

Derivados de pirina con actividad inhibidora de quinasa ikb (ikk-beta)

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Publication number
ECSP034524A
ECSP034524A EC2003004524A ECSP034524A ECSP034524A EC SP034524 A ECSP034524 A EC SP034524A EC 2003004524 A EC2003004524 A EC 2003004524A EC SP034524 A ECSP034524 A EC SP034524A EC SP034524 A ECSP034524 A EC SP034524A
Authority
EC
Ecuador
Prior art keywords
amino
quinasa
pirina
ikb
ikk
Prior art date
Application number
EC2003004524A
Other languages
English (en)
Inventor
Mitsuyuki Shimada
Timothy B Lowinger
Toshiki Murata
Kinji Fuchikami
Masaomi Umeda
Karl Ziegelbauer
Hiroshi Sato
Hiroshi Kadono
Sachiko Sakakibara
Takashi Yoshino
Hiroshi Komura
Tsutomu Masuda
Yuji Koriyama
Takuya Shintani
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ECSP034524A publication Critical patent/ECSP034524A/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/08—Preparation by ring-closure
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

En la que R11 representa hidrógeno, alquilo C1-6-sulfonilamino, alcoxi C1-6-carbonilo, alquil C1-6-amino, de(alquil C1-6)amino, alcanoil C1-6-amino, fenialquil C1-6-amino, fenilsulfonilamino o -O-(CH2)n-R111;R2 representa hidrógeno o halógeno; R3 representa hidrógeno, -CR31R32R33, o -NR34R35; R4 es hidrógeno, carbamoílo, CN, carboxilo, etc. R5 es amino, alquilamino C1-6, di(alquil C1-6)amino, etc o una de sus sales. El compuesto presenta una actividad antiinflamatoria excelente y otras actividades biológicas.
EC2003004524A 2000-09-22 2003-03-21 Derivados de pirina con actividad inhibidora de quinasa ikb (ikk-beta) ECSP034524A (es)

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HUP0303124A2 (hu) 2003-12-29
US7232909B2 (en) 2007-06-19
AR031613A1 (es) 2003-09-24
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IL154550A0 (en) 2003-09-17
CN1476442A (zh) 2004-02-18
WO2002024679A1 (en) 2002-03-28
MXPA03002491A (es) 2004-12-06
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SK3452003A3 (en) 2004-01-08
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RU2003111754A (ru) 2004-10-27
ES2298260T3 (es) 2008-05-16
WO2002024693A1 (en) 2002-03-28
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NO20031307D0 (no) 2003-03-21
AU2001289875A1 (en) 2002-04-02
CA2422923A1 (en) 2002-03-28
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GT200100189A (es) 2002-05-16
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US20060100246A1 (en) 2006-05-11
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