ES2191985T3 - S-oxido de tetrahidrotiopirano feniloxazolidinonas. - Google Patents

S-oxido de tetrahidrotiopirano feniloxazolidinonas.

Info

Publication number
ES2191985T3
ES2191985T3 ES98962811T ES98962811T ES2191985T3 ES 2191985 T3 ES2191985 T3 ES 2191985T3 ES 98962811 T ES98962811 T ES 98962811T ES 98962811 T ES98962811 T ES 98962811T ES 2191985 T3 ES2191985 T3 ES 2191985T3
Authority
ES
Spain
Prior art keywords
tetrahydrotiopirane
phenyloxazolidinones
oxide
formula
dichloropropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98962811T
Other languages
English (en)
Inventor
Toni-Jo Poel
Joseph P Martin Jr
Michael R Barbachyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2191985T3 publication Critical patent/ES2191985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catalysts (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de fórmula I **(Fórmula)** O sus sales farmacéuticamente aceptables del mismo en la que: R1 es a) metilo, b) etilo, c) dicloropropilo, o d) diclorometilo; R2 y R3 son iguales o diferentes y son a) hidrógeno, o b) flúor.
ES98962811T 1997-12-05 1998-11-23 S-oxido de tetrahidrotiopirano feniloxazolidinonas. Expired - Lifetime ES2191985T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6783097P 1997-12-05 1997-12-05
US8949898P 1998-06-16 1998-06-16
US10018598P 1998-09-14 1998-09-14

Publications (1)

Publication Number Publication Date
ES2191985T3 true ES2191985T3 (es) 2003-09-16

Family

ID=27371238

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98962811T Expired - Lifetime ES2191985T3 (es) 1997-12-05 1998-11-23 S-oxido de tetrahidrotiopirano feniloxazolidinonas.

Country Status (21)

Country Link
US (2) US6083967A (es)
EP (2) EP1036074B1 (es)
JP (1) JP2001525408A (es)
KR (1) KR20010032782A (es)
CN (2) CN1532535A (es)
AT (1) ATE231859T1 (es)
AU (2) AU752454B2 (es)
BR (1) BR9814897A (es)
CA (1) CA2309026A1 (es)
DE (1) DE69811117T2 (es)
DK (1) DK1036074T3 (es)
ES (1) ES2191985T3 (es)
HU (1) HUP0100558A3 (es)
ID (1) ID21450A (es)
NO (1) NO316447B1 (es)
NZ (1) NZ504930A (es)
PL (1) PL340835A1 (es)
SI (1) SI1036074T1 (es)
SK (1) SK7692000A3 (es)
TW (2) TW553942B (es)
WO (1) WO1999029688A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511468B1 (en) 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
TR200003595T2 (tr) 1998-06-05 2001-07-23 Astrazeneca Ab Kimyasal bileşikler
MY120189A (en) * 1999-11-04 2005-09-30 Upjohn Co Sultam and sultone derived oxazolidinones
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
ES2258234T3 (es) 2002-08-12 2006-08-16 PHARMACIA & UPJOHN COMPANY LLC N-aril-2-oxazolidinonas y sus derivados.
JP2006509035A (ja) 2002-11-21 2006-03-16 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのｎ−（４−（ピペラジン−１−イル）−フェニル−２−オキサゾリジノン−５−カルボキサミド誘導体および関連化合物
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
US8188270B2 (en) 2005-10-04 2012-05-29 Bayer Schering Pharma Aktiengesellschaft Polymorphous form of 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
CN102262066A (zh) * 2011-06-16 2011-11-30 董理 一种检测单胺氧化酶含量的方法和试剂盒
CN104610479B (zh) * 2013-11-05 2017-03-29 中国石油化工股份有限公司 用于乙烯聚合的负载化茂金属催化剂及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897409A (en) * 1986-09-03 1990-01-30 Delalande S.A. 5-aminoethyloxazolidin-2-one derivatives
US4885154A (en) * 1988-03-01 1989-12-05 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5130316A (en) * 1988-07-29 1992-07-14 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
JP2669579B2 (ja) * 1991-10-23 1997-10-29 エーザイ株式会社 オキサゾリドン誘導体
ATE146783T1 (de) * 1991-11-01 1997-01-15 Upjohn Co Substituierte aryl- und heteroaryl- phenyloxazolidinone
EP0673370B1 (en) * 1992-12-08 1998-01-07 PHARMACIA & UPJOHN COMPANY Tropone-substituted phenyloxazolidinone antibacterial agents
RU2175324C2 (ru) * 1995-09-01 2001-10-27 Фармация Энд Апджон Компани Фенилоксазолидиноны, имеющие с-с-связь с 4-8-членными гетероциклическими кольцами
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
NO316447B1 (no) 2004-01-26
NO20002834L (no) 2000-07-21
TWI239331B (en) 2005-09-11
AU752454B2 (en) 2002-09-19
ID21450A (id) 1999-06-10
SK7692000A3 (en) 2001-03-12
CN1532535A (zh) 2004-09-29
EP1036074A1 (en) 2000-09-20
ATE231859T1 (de) 2003-02-15
CA2309026A1 (en) 1999-06-17
AU1796899A (en) 1999-06-28
CN1278817A (zh) 2001-01-03
DE69811117D1 (de) 2003-03-06
AU2002301031B2 (en) 2005-08-25
TW200307673A (en) 2003-12-16
HUP0100558A3 (en) 2002-08-28
DE69811117T2 (de) 2003-07-17
US6083967A (en) 2000-07-04
EP1254906A1 (en) 2002-11-06
DK1036074T3 (da) 2003-06-23
NZ504930A (en) 2002-05-31
JP2001525408A (ja) 2001-12-11
US6265178B1 (en) 2001-07-24
SI1036074T1 (en) 2003-08-31
NO20002834D0 (no) 2000-06-02
KR20010032782A (ko) 2001-04-25
PL340835A1 (en) 2001-02-26
WO1999029688A1 (en) 1999-06-17
CN1154645C (zh) 2004-06-23
HUP0100558A2 (hu) 2002-05-29
EP1036074B1 (en) 2003-01-29
HK1032970A1 (en) 2001-08-10
TW553942B (en) 2003-09-21
BR9814897A (pt) 2000-10-03

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