ECSP034574A - Derivados de naftaleno - Google Patents

Derivados de naftaleno

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Publication number
ECSP034574A
ECSP034574A EC2003004574A ECSP034574A ECSP034574A EC SP034574 A ECSP034574 A EC SP034574A EC 2003004574 A EC2003004574 A EC 2003004574A EC SP034574 A ECSP034574 A EC SP034574A EC SP034574 A ECSP034574 A EC SP034574A
Authority
EC
Ecuador
Prior art keywords
derivatives
naftalene
formula
ch2nh
nr5r6
Prior art date
Application number
EC2003004574A
Other languages
English (en)
Inventor
Edward Carol Dziadulewicz
Andrew James Culshaw
Christopher Thomas Brian
Ulrich Schopfer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP034574A publication Critical patent/ECSP034574A/es

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    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
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    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C323/21—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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Abstract

La presente invención se refiere a derivados de naftaleno novedosos de la fórmula (I) en donde X es -S-, -S-, -S(0)-1-S(0)2NH-, P(0) (OCH-, -P(O) (OH)-, -NH-, -N(CH3)-, -NHC(0)NH-, -C(0) -, -C(O) 0-, -CH (OH)-, -CH=N-, -CH=CH-, -CH2NH-O-C(=NH)-; R1 es arilo o heteroarilo; R2 es hidrógeno, OR4, o NR5R6; y las altas variables son como se definen en la descripción, y a su preparación. Los compuestos de la fórmula (I) son útiles como productos farmacéuticos en el tratamiento o prevención de una enfermedad o condición en donde tenga un papel o este implicada la activación del receptor canabinoide. (I)-
EC2003004574A 2000-11-24 2003-04-29 Derivados de naftaleno ECSP034574A (es)

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