ECSP044978A - ANTICUERPOS HUMANOS ANTAGONISTAS CONTRA hTNFSF13b - Google Patents

ANTICUERPOS HUMANOS ANTAGONISTAS CONTRA hTNFSF13b

Info

Publication number
ECSP044978A
ECSP044978A EC2004004978A ECSP044978A ECSP044978A EC SP044978 A ECSP044978 A EC SP044978A EC 2004004978 A EC2004004978 A EC 2004004978A EC SP044978 A ECSP044978 A EC SP044978A EC SP044978 A ECSP044978 A EC SP044978A
Authority
EC
Ecuador
Prior art keywords
htnfsf13b
tnfsf13b
antibodies
activity
human antibodies
Prior art date
Application number
EC2004004978A
Other languages
English (en)
Inventor
John Edward Hale
Radhakrishnan Rathnachalam
Derrick Ryan Witcher
Valentina Pavlovna Gelfanova
Kristine Kay Kikly
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23213094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP044978(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP044978A publication Critical patent/ECSP044978A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen anticuerpos monoclonales humanos que se unen específicamente a polipéptidos TNFSF13b. Estos anticuerpos presentan afinidad elevada por hTNFSF13b (por ejemplo, KD = 10-8 M o menor), una lenta velocidad de disociación de TNFSF13b (por ejemplo, Koff = 10-3 s-1 o menor) y neutralizan la actividad de TNFSF13b in vitro e in vivo. Los anticuerpos de la invención son de utilidad en una realización para inhibir la actividad de TNFSF13b en un sujeto humano que padece un trastorno en el que la actividad de hTNFSF13b es perjudicial. También están comprendidos en la invención los ácidos nucleicos que codifican los anticuerpos de la presente invención, así como los vectores y células hospedadoras para su expresión.
EC2004004978A 2001-08-16 2004-02-13 ANTICUERPOS HUMANOS ANTAGONISTAS CONTRA hTNFSF13b ECSP044978A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31280801P 2001-08-16 2001-08-16

Publications (1)

Publication Number Publication Date
ECSP044978A true ECSP044978A (es) 2004-03-23

Family

ID=23213094

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004004978A ECSP044978A (es) 2001-08-16 2004-02-13 ANTICUERPOS HUMANOS ANTAGONISTAS CONTRA hTNFSF13b

Country Status (26)

Country Link
US (4) US7317089B2 (es)
EP (2) EP1432735B1 (es)
JP (1) JP4012880B2 (es)
KR (1) KR100961299B1 (es)
CN (1) CN100497392C (es)
AR (1) AR035119A1 (es)
AU (2) AU2002322436C1 (es)
BR (1) BR0211630A (es)
CA (1) CA2452447C (es)
CO (1) CO5560617A2 (es)
DK (2) DK1432735T3 (es)
EA (1) EA009074B1 (es)
EC (1) ECSP044978A (es)
ES (2) ES2389834T3 (es)
HR (1) HRP20040147A2 (es)
HU (1) HU230006B1 (es)
IL (1) IL160373A0 (es)
MX (1) MXPA04001344A (es)
NO (1) NO20040603L (es)
NZ (1) NZ530657A (es)
PE (1) PE20030334A1 (es)
PL (1) PL212404B1 (es)
PT (2) PT2348048E (es)
UA (1) UA89017C2 (es)
WO (1) WO2003016468A2 (es)
ZA (1) ZA200401154B (es)

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Also Published As

Publication number Publication date
ES2389834T3 (es) 2012-11-02
JP4012880B2 (ja) 2007-11-21
AU2002322436B2 (en) 2008-12-04
US20100272735A1 (en) 2010-10-28
US20080175841A1 (en) 2008-07-24
BR0211630A (pt) 2004-11-09
UA89017C2 (uk) 2009-12-25
CN100497392C (zh) 2009-06-10
PT1432735E (pt) 2012-09-10
MXPA04001344A (es) 2004-05-05
AU2008246261B2 (en) 2011-04-07
US8173124B2 (en) 2012-05-08
JP2005517384A (ja) 2005-06-16
PL212404B1 (pl) 2012-09-28
US7317089B2 (en) 2008-01-08
ZA200401154B (en) 2005-06-22
ES2526990T3 (es) 2015-01-19
HUP0500816A2 (en) 2007-07-30
CN1541224A (zh) 2004-10-27
IL160373A0 (en) 2004-07-25
CO5560617A2 (es) 2005-09-30
EP1432735B1 (en) 2012-07-18
US20120195904A1 (en) 2012-08-02
KR100961299B1 (ko) 2010-06-04
KR20040030088A (ko) 2004-04-08
NO20040603L (no) 2004-05-14
US20050070694A1 (en) 2005-03-31
WO2003016468A2 (en) 2003-02-27
US7728109B2 (en) 2010-06-01
EP1432735A4 (en) 2007-06-27
PE20030334A1 (es) 2003-04-05
CA2452447C (en) 2012-04-24
HRP20040147A2 (en) 2004-10-31
AU2008246261A1 (en) 2008-12-11
HU230006B1 (en) 2015-04-28
EP2348048A1 (en) 2011-07-27
EA009074B1 (ru) 2007-10-26
PL370534A1 (en) 2005-05-30
AU2002322436C1 (en) 2011-09-01
EP1432735A2 (en) 2004-06-30
CA2452447A1 (en) 2003-02-27
DK1432735T3 (da) 2012-08-06
AR035119A1 (es) 2004-04-14
HUP0500816A3 (en) 2010-01-28
PT2348048E (pt) 2015-02-04
NZ530657A (en) 2006-02-24
WO2003016468A3 (en) 2003-11-20
AU2002322436B9 (en) 2009-04-09
DK2348048T3 (en) 2014-12-15
EA200400312A1 (ru) 2004-10-28
EP2348048B1 (en) 2014-11-19

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