ECSP045092A - AMIDAS OF ANTRANILIC ACID AND ITS USE AS VEGF RECEPTOR THYROSINE-KINASE INHIBITORS - Google Patents
AMIDAS OF ANTRANILIC ACID AND ITS USE AS VEGF RECEPTOR THYROSINE-KINASE INHIBITORSInfo
- Publication number
- ECSP045092A ECSP045092A ECSP045092A ECSP045092A EC SP045092 A ECSP045092 A EC SP045092A EC SP045092 A ECSP045092 A EC SP045092A EC SP045092 A ECSP045092 A EC SP045092A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- disease
- amidas
- kinase inhibitors
- vegf receptor
- Prior art date
Links
- 108091008605 VEGF receptors Proteins 0.000 title 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 title 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 208000017442 Retinal disease Diseases 0.000 abstract 2
- 206010038923 Retinopathy Diseases 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 208000002780 macular degeneration Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001613 neoplastic effect Effects 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010064930 age-related macular degeneration Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a derivados de amida de ácido antranílico de la fórmula (I), en donde R1 representa H o alquilo inferior, R2 representa H o alquilo inferior, R3 representa perfluoroalquilo inferior, y X es O u S, o un N-óxido o su tautómero, a sales de dichas amidas de ácido antranílico, sus N-óxidos y sus tautómeros; a procesos para su preparación, su aplicación para el tratamiento del cuerpo del ser humano o animal, su uso - solos o en combinación con uno o más de otros compuestos farmacéuticamente activos - para especialmente el tratamiento de una enfermedad neoplástica, tal como una enfermedad tumoral, de retinopatía o degeneración macular relacionada con la edad; a un método para el tratamiento de dicha enfermedad en animales, especialmente seres humanos, y al uso de dichos compuestos - solos o en combinación con uno o más de otros compuestos farmacéuticamente activos - para la fabricación de una preparación farmacéutica para el tratamiento de una enfermedad neoplástica, de retinopatía o degeneración macular relacionada con la edad.The invention relates to anthranilic acid amide derivatives of the formula (I), wherein R1 represents H or lower alkyl, R2 represents H or lower alkyl, R3 represents lower perfluoroalkyl, and X is O or S, or an N- oxide or its tautomer, to salts of said anthranilic acid amides, their N-oxides and their tautomers; to processes for its preparation, its application for the treatment of the body of the human or animal being, its use - alone or in combination with one or more other pharmaceutically active compounds - for especially the treatment of a neoplastic disease, such as a tumor disease , of age-related retinopathy or macular degeneration; to a method for the treatment of said disease in animals, especially humans, and to the use of said compounds - alone or in combination with one or more other pharmaceutically active compounds - for the manufacture of a pharmaceutical preparation for the treatment of a disease neoplastic, retinopathy or age-related macular degeneration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045092 ECSP045092A (en) | 2004-05-03 | 2004-05-03 | AMIDAS OF ANTRANILIC ACID AND ITS USE AS VEGF RECEPTOR THYROSINE-KINASE INHIBITORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP045092 ECSP045092A (en) | 2004-05-03 | 2004-05-03 | AMIDAS OF ANTRANILIC ACID AND ITS USE AS VEGF RECEPTOR THYROSINE-KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045092A true ECSP045092A (en) | 2004-06-28 |
Family
ID=40435100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP045092 ECSP045092A (en) | 2004-05-03 | 2004-05-03 | AMIDAS OF ANTRANILIC ACID AND ITS USE AS VEGF RECEPTOR THYROSINE-KINASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP045092A (en) |
-
2004
- 2004-05-03 EC ECSP045092 patent/ECSP045092A/en unknown
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