ECSP045229A - Piridinonas sustituidas como moduladores de la p38 map quinasa - Google Patents

Piridinonas sustituidas como moduladores de la p38 map quinasa

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Publication number
ECSP045229A
ECSP045229A EC2004005229A ECSP045229A ECSP045229A EC SP045229 A ECSP045229 A EC SP045229A EC 2004005229 A EC2004005229 A EC 2004005229A EC SP045229 A ECSP045229 A EC SP045229A EC SP045229 A ECSP045229 A EC SP045229A
Authority
EC
Ecuador
Prior art keywords
map
piridinones
quinasa
modulators
replaced
Prior art date
Application number
EC2004005229A
Other languages
English (en)
Inventor
Balekudru Devadas
John Walker
Shaun R Selness
Terri L Boehm
Richard Durley
Rajes Devraj
Brian S Hickory
Paul V Rucker
Kevin D Jerome
Heather M Madsen
Edgardo Alvira
Michele A Promo
Radhika M Blevis-Bal
Laura D Marrufo
Jeff Hitchcock
Thomas Owen
Win Naing
Li Xing
Huey S Shieh
Aruna Sambandam
Shuang Liu
Ian L Scott
Kevin F Mcgee
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of ECSP045229A publication Critical patent/ECSP045229A/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/64—One oxygen atom attached in position 2 or 6
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Abstract

Se describen compuestos de la Fórmula I y sus sales farmacéuticamente aceptables, en los que R1, R2, R3, R4, y R5 se definen en la presente. Estos compuestos son útiles para tratar enfermedades y afecciones causadas o exacerbadas por la actividad de p38 MAP quinasa desregulada y/o FNT. También se describen composiciones farmacéuticas que contienen estos compuestos y su preparación.
EC2004005229A 2002-02-14 2004-08-12 Piridinonas sustituidas como moduladores de la p38 map quinasa ECSP045229A (es)

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