ECSP045297A - MICROGLY INHIBITORS TO INTERRUPT IMMUNE REACTIONS ASSOCIATED WITH INTERLEUCINE 12 AND IFN? - Google Patents
MICROGLY INHIBITORS TO INTERRUPT IMMUNE REACTIONS ASSOCIATED WITH INTERLEUCINE 12 AND IFN?Info
- Publication number
- ECSP045297A ECSP045297A EC2004005297A ECSP045297A ECSP045297A EC SP045297 A ECSP045297 A EC SP045297A EC 2004005297 A EC2004005297 A EC 2004005297A EC SP045297 A ECSP045297 A EC SP045297A EC SP045297 A ECSP045297 A EC SP045297A
- Authority
- EC
- Ecuador
- Prior art keywords
- inhibitors
- microgly
- interleucine
- ifn
- interrupt
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 210000000274 microglia Anatomy 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere al uso de inhibidores de la microglía para preparar fármacos que inhiben las reacciones inmunes asociadas con monocitos, macrófagos y células-T y a su uso para el tratamiento de enfermedades inmunológicas asociadas con células-T y reacciones inflamatorias no asociadas con células-T.The invention relates to the use of microglia inhibitors to prepare drugs that inhibit the immune reactions associated with monocytes, macrophages and T-cells and their use for the treatment of immunological diseases associated with T-cells and inflammatory reactions not associated with cells. T.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10207843A DE10207843A1 (en) | 2002-02-15 | 2002-02-15 | Microlia inhibitors for interruption of interleukin 12 and IFN-gamma mediated immune responses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045297A true ECSP045297A (en) | 2004-10-26 |
Family
ID=27674912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004005297A ECSP045297A (en) | 2002-02-15 | 2004-09-14 | MICROGLY INHIBITORS TO INTERRUPT IMMUNE REACTIONS ASSOCIATED WITH INTERLEUCINE 12 AND IFN? |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1474138A1 (en) |
| JP (1) | JP2005522447A (en) |
| KR (1) | KR20040084909A (en) |
| CN (1) | CN1756546A (en) |
| AR (1) | AR039556A1 (en) |
| AU (1) | AU2003245523A1 (en) |
| BR (1) | BR0307706A (en) |
| CA (1) | CA2475770A1 (en) |
| DE (1) | DE10207843A1 (en) |
| EC (1) | ECSP045297A (en) |
| MX (1) | MXPA04007943A (en) |
| NO (1) | NO20043840L (en) |
| PE (1) | PE20030906A1 (en) |
| PL (1) | PL371327A1 (en) |
| RS (1) | RS71304A (en) |
| RU (1) | RU2004127677A (en) |
| TW (1) | TW200306823A (en) |
| UA (1) | UA81111C2 (en) |
| UY (1) | UY27662A1 (en) |
| WO (1) | WO2003068225A1 (en) |
| ZA (1) | ZA200407382B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10207844A1 (en) * | 2002-02-15 | 2003-09-04 | Schering Ag | 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the preparation of medicaments and pharmaceutical preparations containing these derivatives |
| HRP20090646T1 (en) * | 2005-03-17 | 2010-01-31 | Proyecto De Biomedicina Cima | Use of 5'-methylthioadenosine (mta) in the prevention and/or treatment of autoimmune diseases and/or transplant rejection |
| US9550737B2 (en) * | 2012-06-11 | 2017-01-24 | Ucb Biopharma Sprl | TNF -α modulating benzimidazoles |
| US9586949B2 (en) | 2015-02-09 | 2017-03-07 | Incyte Corporation | Aza-heteroaryl compounds as PI3K-gamma inhibitors |
| EP4086259A1 (en) | 2015-11-06 | 2022-11-09 | Incyte Corporation | Heterocyclic compounds as pi3k-gamma inhibitors |
| KR20180094989A (en) * | 2015-12-15 | 2018-08-24 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 | A method for preventing and / or treating aging-related cognitive disorders and neuroinflammation |
| WO2017120194A1 (en) | 2016-01-05 | 2017-07-13 | Incyte Corporation | Pyridine and pyridimine compounds as pi3k-gamma inhibitors |
| WO2017223414A1 (en) | 2016-06-24 | 2017-12-28 | Incyte Corporation | HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS |
| IL295978B2 (en) | 2017-10-18 | 2024-01-01 | Incyte Corp | Concentrated imidazole derivatives substituted by tertiary hydroxy groups as P13K-gamma inhibitors |
| CR20250050A (en) | 2018-09-05 | 2025-03-19 | Incyte Corp | Crystalline forms of a phosphoinositide 3-kinase (pi3k) inhibitor |
| HUE066335T2 (en) | 2018-10-05 | 2024-07-28 | Annapurna Bio Inc | Compounds and compositions for treating conditions associated with apj receptor activity |
| CN112341450B (en) * | 2019-08-09 | 2022-05-17 | 成都先导药物开发股份有限公司 | Immunomodulator |
| CN112341451B (en) * | 2019-08-09 | 2022-06-17 | 成都先导药物开发股份有限公司 | Immunomodulator |
| CN115768757B (en) * | 2019-12-19 | 2025-07-11 | 美利坚合众国,由健康及人类服务部部长代表 | CD206 modulator and its use and preparation method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4330959A1 (en) * | 1993-09-09 | 1995-03-16 | Schering Ag | New benzimidazole derivatives, processes for their preparation and their pharmaceutical use |
| BR0107628A (en) * | 2000-01-14 | 2002-10-08 | Schering Ag | 1,2-diarylbenzimidazoles for treating diseases that are associated with microglial activation |
| DE10134775A1 (en) * | 2001-07-06 | 2003-01-30 | Schering Ag | 1-alkyl-2.aryl-benzimidazole derivatives, their use for the manufacture of medicaments and pharmaceutical preparations containing these derivatives |
| DE10135050A1 (en) * | 2001-07-09 | 2003-02-06 | Schering Ag | 1-Ary1-2-N-, S- or O-substituted benzimidazole derivatives, their use for the preparation of medicaments and pharmaceutical preparations containing them |
-
2002
- 2002-02-15 DE DE10207843A patent/DE10207843A1/en not_active Ceased
-
2003
- 2003-01-17 CN CNA038039923A patent/CN1756546A/en active Pending
- 2003-01-17 WO PCT/EP2003/000467 patent/WO2003068225A1/en not_active Ceased
- 2003-01-17 RS YU71304A patent/RS71304A/en unknown
- 2003-01-17 RU RU2004127677/15A patent/RU2004127677A/en unknown
- 2003-01-17 AU AU2003245523A patent/AU2003245523A1/en not_active Abandoned
- 2003-01-17 MX MXPA04007943A patent/MXPA04007943A/en unknown
- 2003-01-17 EP EP03739380A patent/EP1474138A1/en not_active Withdrawn
- 2003-01-17 BR BR0307706-3A patent/BR0307706A/en not_active IP Right Cessation
- 2003-01-17 JP JP2003567407A patent/JP2005522447A/en active Pending
- 2003-01-17 KR KR10-2004-7012557A patent/KR20040084909A/en not_active Ceased
- 2003-01-17 UA UA20040907401A patent/UA81111C2/en unknown
- 2003-01-17 CA CA002475770A patent/CA2475770A1/en not_active Abandoned
- 2003-01-17 PL PL03371327A patent/PL371327A1/en not_active Application Discontinuation
- 2003-02-03 PE PE2003000119A patent/PE20030906A1/en not_active Application Discontinuation
- 2003-02-11 UY UY27662A patent/UY27662A1/en not_active Application Discontinuation
- 2003-02-12 AR ARP030100436A patent/AR039556A1/en unknown
- 2003-02-14 TW TW092103072A patent/TW200306823A/en unknown
-
2004
- 2004-09-14 ZA ZA200407382A patent/ZA200407382B/en unknown
- 2004-09-14 EC EC2004005297A patent/ECSP045297A/en unknown
- 2004-09-14 NO NO20043840A patent/NO20043840L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20043840L (en) | 2004-11-12 |
| PE20030906A1 (en) | 2004-01-17 |
| UY27662A1 (en) | 2003-09-30 |
| EP1474138A1 (en) | 2004-11-10 |
| TW200306823A (en) | 2003-12-01 |
| AU2003245523A1 (en) | 2003-09-04 |
| CN1756546A (en) | 2006-04-05 |
| MXPA04007943A (en) | 2004-11-26 |
| UA81111C2 (en) | 2007-12-10 |
| AR039556A1 (en) | 2005-02-23 |
| KR20040084909A (en) | 2004-10-06 |
| ZA200407382B (en) | 2005-09-14 |
| JP2005522447A (en) | 2005-07-28 |
| RS71304A (en) | 2006-10-27 |
| WO2003068225A1 (en) | 2003-08-21 |
| PL371327A1 (en) | 2005-06-13 |
| DE10207843A1 (en) | 2003-09-04 |
| RU2004127677A (en) | 2005-06-10 |
| BR0307706A (en) | 2005-01-11 |
| CA2475770A1 (en) | 2003-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP045297A (en) | MICROGLY INHIBITORS TO INTERRUPT IMMUNE REACTIONS ASSOCIATED WITH INTERLEUCINE 12 AND IFN? | |
| BR0208636A (en) | Therapeutic agent for chronic arthritic diseases of childhood-related diseases | |
| ATE466085T1 (en) | PROTEASE-RESISTANT MODIFIED INTERFERON ALPHA POLYPEPTIDES | |
| ES2246567T3 (en) | COMPOSITIONS FOR INHIBITING RECEPTORS OF T-CELLS AND USES OF THE SAME. | |
| CR7875A (en) | IMMUNOGLOBIN VARIANTS AND USES OF THIS | |
| ES2154741T3 (en) | USE OF CD23 UNION AGENTS IN THE TREATMENT OF AUTOIMMUNE DISEASES. | |
| CL2008002207A1 (en) | Pharmaceutical composition comprising immunosuppressants to improve the effect in the use of an antagonist of interleukin-6 (il-6) for the treatment of illnesses related to il-6 (div. Sol. 896-04). | |
| UY27720A1 (en) | MONOCYCLIC AROILPIRIDINONES, | |
| AR005703A1 (en) | SUBSTITUTED OXAZOLIDINONES, PROCEDURE FOR THE PREPARATION, USE OF THE SAME TO PREPARE MEDICINES AND MEDICINES THAT CONTAIN THEM | |
| BRPI0411900B8 (en) | compounds and pharmaceutical compositions comprising them | |
| UY28080A1 (en) | POSITIONAL ISOMERS OF IFN PEG ALFA 2A | |
| UY26370A1 (en) | "IMIDAZO-5-IL-AMICAS BICÍCLICAS, DRUGS CONTAINING THEM, THEIR USE FOR THE PREPARATION OF DRUGS AND PROCEDURE FOR THE PREPARATION". | |
| DE69430059D1 (en) | Release and mobilization of hematopoietic cells | |
| EP1578373A4 (en) | NEW COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE IMMUNE SYSTEM | |
| PT1017667E (en) | 2-AMINO-6-METHYL-7-ACETYL-TETRALINE AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND / OR AUTOIMAL NATURE PATOLOGIES | |
| UY27312A1 (en) | NEW HETEROCICLOS 3 | |
| ATE431742T1 (en) | MODIFIED CYTOKINE FOR CANCER THERAPY | |
| CR7441A (en) | MICROGLY INHIBITORS TO INTERRUPT IMMUNE REACTIONS ASSOCIATED WITH INTERLEUCINE 12 AND IFNY | |
| DK1012286T3 (en) | Allele variant of human STAT3 | |
| UY26945A1 (en) | PHENOXYPHENYL ALCANOSULPHONATES | |
| ECSP045296A (en) | DERIVATIVES OF BENZIMIDAZOL 1-FENIL-2-HETEROARIL-SUBSTITUTES, ITS USE TO PREPARE MEDICATIONS FOR THE TREATMENT OF IMMUNOLOGICAL DISEASES | |
| DK1107779T3 (en) | Drugs for Minipulation of T-Cell Immune Response | |
| ES2188538T3 (en) | USE OF 15-DEOXIPERGUALINE FOR THE TREATMENT OF HYPERREACTIVE INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES. | |
| MD2053C2 (en) | Remedy with interferon inducing action | |
| DOP2002000404A (en) | NEW HETEROCUCLES 3. |