ECSP045306A - COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION - Google Patents
COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATIONInfo
- Publication number
- ECSP045306A ECSP045306A ECSP045306A ECSP045306A EC SP045306 A ECSP045306 A EC SP045306A EC SP045306 A ECSP045306 A EC SP045306A EC SP045306 A ECSP045306 A EC SP045306A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- procedures
- preparation
- relates
- ppar activity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title abstract 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 102000016267 Leptin Human genes 0.000 abstract 1
- 108010092277 Leptin Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 230000036528 appetite Effects 0.000 abstract 1
- 235000019789 appetite Nutrition 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 abstract 1
- 201000008980 hyperinsulinism Diseases 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 abstract 1
- 229940039781 leptin Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a compuestos que alteran la actividad de PPAR. La invención también se refiere a las sales farmacéuticamente aceptables de los compuestos, las composiciones farmacéuticamente aceptables que comprenden los compuestos o sus sales, y los procedimientos de utilización de éstos como agentes terapéuticos para tratar o prevenir la hiperlipidemia, la hipercolesteremia, la obesidad, los trastornos alimentarios, la hiperglucemia, la aterosclerosis, la hipertrigliceridemia, la hiperinsulinemia y la diabetes en un mamífero, así como procedimientos para suprimir el apetito y modular los niveles de leptina en un mamífero. La presente invención se refiere también a procedimientos para la elaboración de los compuestos descritos.The invention relates to compounds that alter the activity of PPAR. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents to treat or prevent hyperlipidemia, hypercholesterolemia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal, as well as procedures to suppress appetite and modulate leptin levels in a mammal. The present invention also relates to processes for the preparation of the described compounds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37050802P | 2002-04-05 | 2002-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045306A true ECSP045306A (en) | 2004-10-26 |
Family
ID=38291072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP045306 ECSP045306A (en) | 2002-04-05 | 2004-09-21 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION |
Country Status (2)
| Country | Link |
|---|---|
| EC (1) | ECSP045306A (en) |
| ZA (1) | ZA200407008B (en) |
-
2004
- 2004-09-02 ZA ZA200407008A patent/ZA200407008B/en unknown
- 2004-09-21 EC ECSP045306 patent/ECSP045306A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200407008B (en) | 2006-06-28 |
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