ECSP055537A - Monoclorhidrato de 2,5-diona-3-(1-metil-1h-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1h-indol-3-il]-1h-pirrol cristalino - Google Patents

Monoclorhidrato de 2,5-diona-3-(1-metil-1h-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1h-indol-3-il]-1h-pirrol cristalino

Info

Publication number
ECSP055537A
ECSP055537A EC2005005537A ECSP055537A ECSP055537A EC SP055537 A ECSP055537 A EC SP055537A EC 2005005537 A EC2005005537 A EC 2005005537A EC SP055537 A ECSP055537 A EC SP055537A EC SP055537 A ECSP055537 A EC SP055537A
Authority
EC
Ecuador
Prior art keywords
indol
piperidin
methyl
monoclorhydrate
ilmetil
Prior art date
Application number
EC2005005537A
Other languages
English (en)
Inventor
Julie Kay Bush
Margaret Mary Faul
Susan Marie Reutzel-Edens
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42799191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP055537(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP055537A publication Critical patent/ECSP055537A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a la sal monoclorhidrato de 2,5-diona-3-(1-metil-1H-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1H-indol-3-il]-1H-pirrol cristalino, a una formulación farmacéutica que contenga dicha sal y a procedimientos de tratamiento del cáncer y de inhibición del crecimiento tumoral utilizando dicha sal.
EC2005005537A 2002-07-12 2005-01-12 Monoclorhidrato de 2,5-diona-3-(1-metil-1h-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1h-indol-3-il]-1h-pirrol cristalino ECSP055537A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39597602P 2002-07-12 2002-07-12

Publications (1)

Publication Number Publication Date
ECSP055537A true ECSP055537A (es) 2005-03-10

Family

ID=42799191

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005537A ECSP055537A (es) 2002-07-12 2005-01-12 Monoclorhidrato de 2,5-diona-3-(1-metil-1h-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1h-indol-3-il]-1h-pirrol cristalino

Country Status (21)

Country Link
US (2) US8114901B2 (es)
EP (1) EP1523313B1 (es)
JP (2) JP4771356B2 (es)
KR (1) KR100687165B1 (es)
CN (1) CN100430058C (es)
AU (1) AU2003280958B9 (es)
CA (1) CA2393720C (es)
DE (1) DE60317675T2 (es)
EA (1) EA007463B1 (es)
EC (1) ECSP055537A (es)
ES (1) ES2295605T3 (es)
HR (1) HRP20050035B1 (es)
IL (1) IL165747A (es)
NO (1) NO330254B1 (es)
NZ (1) NZ537137A (es)
PE (1) PE20040652A1 (es)
PL (1) PL373046A1 (es)
TW (1) TWI315667B (es)
UA (1) UA78801C2 (es)
WO (1) WO2004006928A1 (es)
ZA (1) ZA200500065B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006207321B2 (en) 2005-01-21 2012-09-06 Astex Therapeutics Limited Pharmaceutical compounds
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
EP2408369A1 (en) 2009-03-02 2012-01-25 Seventh Sense Biosystems, Inc. Devices and methods for the analysis of an extractable medium
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
CN103068308B (zh) 2010-07-16 2016-03-16 第七感生物系统有限公司 用于流体传输装置的低压环境
MX339926B (es) * 2010-09-30 2016-06-16 Wisconsin Alumni Res Found * (20r, 25s)-metilen-19,26-dinor-1a,25-dihidroxivitamina d3 en forma cristalina.
EP2637562B1 (en) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
CN103874460B (zh) 2011-04-29 2016-06-22 第七感生物系统有限公司 一种用于从受验者的皮肤接收血液或其它物质的装置
EP3106092A3 (en) 2011-04-29 2017-03-08 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
AU2017285384A1 (en) 2016-06-17 2019-02-07 Cells For Cells, S.P.A. Gelatin polymer derived from natural sources of cold-adapted marine species and uses thereof
KR20250023595A (ko) 2016-08-10 2025-02-18 에프. 호프만-라 로슈 아게 Akt 단백질 키나아제 저해제를 포함하는 약학 조성물
JOP20190025A1 (ar) 2016-09-01 2019-02-19 Denovo Biopharma Llc طرق وتركيبة لتوقع نشاط إنزاستورين
CN116199590B (zh) * 2022-12-26 2024-12-24 湖北美林药业有限公司 一种盐酸多巴酚丁胺及其注射剂

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625738A1 (de) * 1986-07-30 1988-02-11 Goedecke Ag 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
EP0303697B1 (en) * 1987-03-09 1997-10-01 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance k-252
DE3803620A1 (de) 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
SK75289A3 (en) * 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
GB8904161D0 (en) * 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
IL94274A0 (en) 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5489608A (en) * 1989-12-21 1996-02-06 Goedecke Aktiengesellschaft Indolocarbazole derivatives and the use thereof
DE4005969A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
CA2046801C (en) 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
GB9123396D0 (en) 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
US5461146A (en) 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
DE4243321A1 (de) 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
AU678435B2 (en) 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
SE501711C2 (sv) * 1993-09-08 1995-05-02 Jimek Int Ab Sprayrör för en duktvättanordning vid en tryckpress
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
ATE456367T1 (de) * 1993-12-23 2010-02-15 Lilly Co Eli Proteinkinase c inhibitoren
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
GB9620390D0 (en) * 1996-09-30 1996-11-13 Eisai London Res Lab Ltd Substances and their uses
EP1204656A2 (en) * 1999-07-29 2002-05-15 Eli Lilly And Company A crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene hydrochloride
WO2001030331A2 (en) * 1999-10-22 2001-05-03 Eli Lilly And Company Therapeutic compositions including protein kinase c inhibitors
AU2001271261A1 (en) * 2000-06-29 2002-01-14 Eli Lilly And Company Therapeutic treatment of cancer with a protein kinase c inhibitor
AU2001271257A1 (en) * 2000-06-29 2002-01-14 Eli Lilly And Company Use of a protein kinase c inhibitor to enhance the clinical efficacy of anti-neoplastic chemotherapeutic agents and radiation therapy
JP2005531609A (ja) * 2002-06-05 2005-10-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キナーゼ阻害剤としてのシスインドリル−マレイミド誘導体

Also Published As

Publication number Publication date
EA007463B1 (ru) 2006-10-27
AU2003280958B8 (en) 2009-02-19
AU2003280958B9 (en) 2009-07-02
TWI315667B (en) 2009-10-11
ZA200500065B (en) 2006-03-29
AU2003280958B2 (en) 2008-12-18
JP5242718B2 (ja) 2013-07-24
NZ537137A (en) 2007-11-30
PL373046A1 (en) 2005-08-08
JP4771356B2 (ja) 2011-09-14
AU2003280958A1 (en) 2004-02-02
CN100430058C (zh) 2008-11-05
KR20050021453A (ko) 2005-03-07
NO20050676L (no) 2005-02-09
PE20040652A1 (es) 2004-10-05
CN1668304A (zh) 2005-09-14
DE60317675D1 (de) 2008-01-03
WO2004006928A1 (en) 2004-01-22
KR100687165B1 (ko) 2007-02-27
DE60317675T2 (de) 2008-10-30
US8114901B2 (en) 2012-02-14
CA2393720A1 (en) 2004-01-16
JP2006502115A (ja) 2006-01-19
IL165747A0 (en) 2006-01-15
HRP20050035B1 (hr) 2013-07-31
HK1075839A1 (en) 2005-12-30
IL165747A (en) 2010-05-17
EA200500191A1 (ru) 2005-06-30
UA78801C2 (en) 2007-04-25
EP1523313A1 (en) 2005-04-20
JP2011144182A (ja) 2011-07-28
TW200408392A (en) 2004-06-01
US20050288332A1 (en) 2005-12-29
EP1523313B1 (en) 2007-11-21
ES2295605T3 (es) 2008-04-16
CA2393720C (en) 2010-09-14
US20070270465A1 (en) 2007-11-22
HRP20050035A2 (en) 2005-04-30
NO330254B1 (no) 2011-03-14

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