ATE279410T1 - 3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen - Google Patents

3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen

Info

Publication number
ATE279410T1
ATE279410T1 AT01948983T AT01948983T ATE279410T1 AT E279410 T1 ATE279410 T1 AT E279410T1 AT 01948983 T AT01948983 T AT 01948983T AT 01948983 T AT01948983 T AT 01948983T AT E279410 T1 ATE279410 T1 AT E279410T1
Authority
AT
Austria
Prior art keywords
inhibitors
aminopyrazoles
cyclin
dependent kinases
useful
Prior art date
Application number
AT01948983T
Other languages
English (en)
Inventor
Mark E Salvati
Spencer David Kimball
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE279410T1 publication Critical patent/ATE279410T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01948983T 2000-02-07 2001-01-23 3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen ATE279410T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18060900P 2000-02-07 2000-02-07
PCT/US2001/002208 WO2001057034A1 (en) 2000-02-07 2001-01-23 3-aminopyrazole inhibitors of cyclin dependent kinases

Publications (1)

Publication Number Publication Date
ATE279410T1 true ATE279410T1 (de) 2004-10-15

Family

ID=22661092

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01948983T ATE279410T1 (de) 2000-02-07 2001-01-23 3-aminopyrazole als inhibitoren von cyclinabhängigen kinasen

Country Status (11)

Country Link
US (2) US6482842B2 (de)
EP (1) EP1268472B1 (de)
JP (1) JP2003522174A (de)
AT (1) ATE279410T1 (de)
AU (2) AU2972701A (de)
CA (1) CA2399274A1 (de)
DE (1) DE60106409T2 (de)
DK (1) DK1268472T3 (de)
ES (1) ES2228905T3 (de)
PT (1) PT1268472E (de)
WO (1) WO2001057034A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60144277D1 (de) 2000-04-25 2011-05-05 Icos Corp Hemmer der menschlichen phosphatidyl-inositol-3-kinase delta
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
AU2003287692A1 (en) * 2002-11-12 2004-06-03 The Board Of Trustees Of The University Of Illinois Induction of cellular senescence by cdk4 disruption for tumor supression and regression
ATE410161T1 (de) * 2003-05-02 2008-10-15 Elan Pharm Inc 4-bromo-5-(2-chloro-benzoylamino)-1h-pyrazol-3- carbonsäureamid-derivate und verwandte verbindungen als bradykinin b1 rezeptor antagonisten zur behandlung von entzündlichen erkrankungen
EP1655287A1 (de) * 2003-08-13 2006-05-10 BF Research Institute, Inc. SONDE F R KRANKHEITEN MIT AMYLOIDABLAGERUNGEN, MITTEL ZUR AMYLOIDANFûRBUNG, HEILMITTEL UND VORBEUGENDES MITTEL F R KRANKHEITEN MIT AMYLOIDABLAGERUNGEN UND DIAGNOSTISCHE SONDE UND ANFûRBEMITTEL F R NEUROFIBRILLûRE VERûNDERUNGEN
WO2005047504A1 (en) * 2003-11-07 2005-05-26 The Board Of Trustees Of The University Of Illinois Induction of cellular senescence by cdk4 disruption for tumor suppression and regression
LT2612862T (lt) 2004-05-13 2017-01-25 Icos Corporation Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės delta inhibitoriai
WO2006127595A1 (en) * 2005-05-23 2006-11-30 Arena Pharmaceuticals, Inc. 5-aminopyrazole carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
KR20170060179A (ko) 2008-11-13 2017-05-31 길리아드 칼리스토가 엘엘씨 혈액 종양에 대한 요법
CA2768843A1 (en) 2009-07-21 2011-01-27 Gilead Calistoga Llc Treatment of liver disorders with pi3k inhibitors
ES2848273T3 (es) 2012-03-05 2021-08-06 Gilead Calistoga Llc Formas polimórficas de (S)-2-(1-(9H-purin-6-ilamino)propilo)-5-fluoro-3-fenilquinazolina-4(3H)-ona
EP3083630B1 (de) 2013-12-20 2019-08-21 Gilead Calistoga LLC Prozessverfahren für phosphatidylinositol-3-kinase-hemmer
JP2017500319A (ja) 2013-12-20 2017-01-05 ギリアード カリストガ エルエルシー （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態
US11021467B2 (en) 2014-06-13 2021-06-01 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416683A (en) * 1980-09-16 1983-11-22 Eli Lilly And Company Benzamides, compositions and agricultural method
JPS6033552A (ja) * 1983-08-04 1985-02-20 Fuji Photo Film Co Ltd カラ−画像形成方法
DE3575130D1 (de) * 1984-05-12 1990-02-08 Fisons Plc Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung.
JPH0743522B2 (ja) * 1985-07-05 1995-05-15 コニカ株式会社 ５―アミノ―１ｈ―ピラゾール系化合物を用いる写真用マゼンタカプラーの合成方法
JPH01258695A (ja) * 1988-04-07 1989-10-16 Yamanouchi Pharmaceut Co Ltd （ピラゾリルアミノ）メチレンビス（ホスホン酸）誘導体及びその医薬
EP0646584A1 (de) * 1991-09-03 1995-04-05 Yamanouchi Pharmaceutical Co. Ltd. Pyrazolotriazolderivate
JPH06210063A (ja) * 1993-01-14 1994-08-02 Kousaku Ishikawa パチンコゲーム機における持ち玉返却機構
CA2203517A1 (en) * 1994-11-10 1996-05-23 Alan M. Laibelman Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
DE19744676A1 (de) 1997-10-10 1999-04-15 Forschungszentrum Borstel Zent Kombinationspräparate für die Therapie von Tumoren
GB9904932D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
HN2000000051A (es) 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
EP1199306B1 (de) 1999-07-26 2005-12-07 Banyu Pharmaceutical Co., Ltd. Biaryl-harnstoff-derivate
MXPA02001498A (es) * 1999-08-12 2003-07-21 Pharmacia & Italia S P A Derivados de 3(5)-amino-pirazol, procedimiento para la preparacion de los mismos y usos como agentes antitumorales.
US6387900B1 (en) * 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents

Also Published As

Publication number Publication date
AU2001229727B2 (en) 2004-10-14
PT1268472E (pt) 2005-01-31
US20010047019A1 (en) 2001-11-29
EP1268472A1 (de) 2003-01-02
DK1268472T3 (da) 2004-12-06
ES2228905T3 (es) 2005-04-16
JP2003522174A (ja) 2003-07-22
DE60106409D1 (de) 2004-11-18
WO2001057034A1 (en) 2001-08-09
US6482842B2 (en) 2002-11-19
DE60106409T2 (de) 2006-02-02
US20030018058A1 (en) 2003-01-23
AU2972701A (en) 2001-08-14
EP1268472B1 (de) 2004-10-13
CA2399274A1 (en) 2001-08-09
US6610724B2 (en) 2003-08-26

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