ECSP055551A - Composiciones de vacunas que contienen arreglos de antígeno amiloide beta 1-6 - Google Patents

Composiciones de vacunas que contienen arreglos de antígeno amiloide beta 1-6

Info

Publication number
ECSP055551A
ECSP055551A EC2005005551A ECSP055551A ECSP055551A EC SP055551 A ECSP055551 A EC SP055551A EC 2005005551 A EC2005005551 A EC 2005005551A EC SP055551 A ECSP055551 A EC SP055551A EC SP055551 A ECSP055551 A EC SP055551A
Authority
EC
Ecuador
Prior art keywords
antigen
composition
provides
arrangements
compositions containing
Prior art date
Application number
EC2005005551A
Other languages
English (en)
Inventor
Martin F Bachmann
Alain Tissot
Rainer Ortmann
Rainer Lueoend
Matthias Staufenbiel
Peter Frey
Original Assignee
Cytos Biotechnology Ag
Novartis Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytos Biotechnology Ag, Novartis Pharma Ag filed Critical Cytos Biotechnology Ag
Publication of ECSP055551A publication Critical patent/ECSP055551A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6075—Viral proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se relaciona con los campos de la biología molecular, virología, inmunología y medicina. La invención proporciona una composición que comprende un arreglo ordenado y repetitivo de antígeno o determinante antigénico, y en particular una composición de péptido Aß1-6-VLP. Más específicamente, la invención proporciona una composición que comprende una partícula parecida a virus y cuando menos un péptido Aß1-6 enlazado a la misma. La invención también proporciona un proceso para producir los conjugados y los arreglos ordenados y repetitivos, respectivamente. Las composiciones de la invención son útiles en la producción de vacunas para el tratamiento de la enfermedad de Alzheimer y como farmavacuna para prevenir o curar la enfermedad de Alzheimer y para inducir de manera eficaz las respuestas inmunes, en particular respuestas de anticuerpos. Además, las composiciones de la invención son particularmente útiles para inducir de manera eficaz respuestas inmunes autoespecíficas dentro del contexto indicado.
EC2005005551A 2002-07-19 2005-01-19 Composiciones de vacunas que contienen arreglos de antígeno amiloide beta 1-6 ECSP055551A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39663902P 2002-07-19 2002-07-19
US47043203P 2003-05-15 2003-05-15

Publications (1)

Publication Number Publication Date
ECSP055551A true ECSP055551A (es) 2005-04-18

Family

ID=31891336

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005551A ECSP055551A (es) 2002-07-19 2005-01-19 Composiciones de vacunas que contienen arreglos de antígeno amiloide beta 1-6

Country Status (23)

Country Link
US (4) US7279165B2 (es)
EP (2) EP1524994B1 (es)
JP (1) JP4644488B2 (es)
KR (2) KR101070078B1 (es)
CN (2) CN1674934B (es)
AT (1) ATE506964T1 (es)
AU (1) AU2003250110C1 (es)
BR (1) BR0312792A (es)
CA (1) CA2492930C (es)
CY (1) CY1111751T1 (es)
DE (1) DE60336902D1 (es)
DK (1) DK1524994T3 (es)
EC (1) ECSP055551A (es)
IL (1) IL166227A (es)
MX (1) MXPA05000819A (es)
NO (1) NO337574B1 (es)
NZ (1) NZ537688A (es)
PL (1) PL217409B1 (es)
PT (1) PT1524994E (es)
RU (1) RU2450827C2 (es)
SI (1) SI1524994T1 (es)
WO (1) WO2004016282A1 (es)
ZA (1) ZA200500151B (es)

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