ECSP055560A - Compuestos heteroaromáticos bicíclicos arilamina sustituidos como inhibidores de la quinasa p38 - Google Patents

Compuestos heteroaromáticos bicíclicos arilamina sustituidos como inhibidores de la quinasa p38

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Publication number
ECSP055560A
ECSP055560A EC2005005560A ECSP055560A ECSP055560A EC SP055560 A ECSP055560 A EC SP055560A EC 2005005560 A EC2005005560 A EC 2005005560A EC SP055560 A ECSP055560 A EC SP055560A EC SP055560 A ECSP055560 A EC SP055560A
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EC
Ecuador
Prior art keywords
group
atom
optionally substituted
inhibitors
bilyclic
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Application number
EC2005005560A
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English (en)
Inventor
Daniel Christopher Brookings
Jeremy Martin Davis
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Celltech R&D Ltd
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Publication date
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of ECSP055560A publication Critical patent/ECSP055560A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
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Abstract

Se describen derivados heteroaromáticos bicíclicos de fórmula (1): donde:la línea discontinua que une a A y C(Ra) está presente y representa un enlace yA es un átomo -N= o un grupo -C(Rb)=, o la línea discontinua está ausente y A es un grupo -N(Rb)-, o -C(Rb)(Rc)-;X es un átomo de -O-, -S- o de nitrógeno sustituido o un grupo -S(O)-, -S(O2)- o -NH-;Y es un átomo de nitrógeno o de carbono sustituido o un grupo -CH=;n es cero o el número entero 1;Alk1 es una cadena alifática o heteroalifática opcionalmente sustituidaL1 es un enlace covalente o un átomo o grupo de unión;Cy1 es un átomo de hidrógeno o un grupo cicloalifático, policicloalifático, heterocicloalifático, poliheterocicloalifático, aromático o heteroaromático opcionalmente sustituido;Ar es un grupo aromático o heteroaromático opcionalmente sustituido; y los sustituyentes restantes fueron definidos en la especificación.Los compuestos son inhibidores selectivos y potentes de la quinasa p38 y son útiles en la profilaxis y el tratamiento de los trastornos inmunitarios o inflamatorios.
EC2005005560A 2002-06-20 2005-01-20 Compuestos heteroaromáticos bicíclicos arilamina sustituidos como inhibidores de la quinasa p38 ECSP055560A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0214268.5A GB0214268D0 (en) 2002-06-20 2002-06-20 Chemical compounds

Publications (1)

Publication Number Publication Date
ECSP055560A true ECSP055560A (es) 2005-05-30

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EC2005005560A ECSP055560A (es) 2002-06-20 2005-01-20 Compuestos heteroaromáticos bicíclicos arilamina sustituidos como inhibidores de la quinasa p38

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US (2) US7423047B2 (es)
EP (1) EP1551848A1 (es)
JP (1) JP2005530838A (es)
KR (1) KR20060013331A (es)
CN (1) CN100390179C (es)
AU (1) AU2003253087B2 (es)
BR (1) BR0311842A (es)
CA (1) CA2487718A1 (es)
EA (1) EA008410B1 (es)
EC (1) ECSP055560A (es)
GB (1) GB0214268D0 (es)
IS (1) IS7652A (es)
MX (1) MXPA04012746A (es)
NO (1) NO20050306L (es)
NZ (1) NZ537740A (es)
PL (1) PL375083A1 (es)
UA (1) UA78578C2 (es)
WO (1) WO2004000846A1 (es)
ZA (1) ZA200500524B (es)

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US7423047B2 (en) 2008-09-09
NO20050306L (no) 2005-03-16
EP1551848A1 (en) 2005-07-13
CN1671715A (zh) 2005-09-21
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GB0214268D0 (en) 2002-07-31
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