UA78578C2 - Bicyclic heteroaromatic derivatives as inhibitors of p38 kinase - Google Patents

Bicyclic heteroaromatic derivatives as inhibitors of p38 kinase Download PDF

Info

Publication number: UA78578C2
Authority: UA; Ukraine
Prior art keywords: group; oxo; hplc; minutes; optionally substituted
Prior art date: 2002-06-20

Application number

UAA200500509A

Other languages

English (en)

Ukrainian (uk)

Inventor

Daniel Christopher Brookings

Jeremy Martin Davis

Barry John Langhem

Original Assignee

Celltech R&D Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-20

Filing date

2003-06-20

Publication date

2007-04-10

2003-06-20 Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd

2007-04-10 Publication of UA78578C2 publication Critical patent/UA78578C2/uk

Links

108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title abstract description 12
102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title abstract description 12
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125000004429 atom Chemical group 0.000 claims abstract description 55
125000003118 aryl group Chemical group 0.000 claims abstract description 35
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125000001931 aliphatic group Chemical group 0.000 claims abstract description 15
229910052799 carbon Inorganic materials 0.000 claims abstract description 15
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 12
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 6
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 141
125000001072 heteroaryl group Chemical group 0.000 claims description 44
125000000217 alkyl group Chemical group 0.000 claims description 43
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
125000005843 halogen group Chemical group 0.000 claims description 20
125000004076 pyridyl group Chemical group 0.000 claims description 17
150000003839 salts Chemical class 0.000 claims description 17
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 15
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UAA200500509A 2002-06-20 2003-06-20 Bicyclic heteroaromatic derivatives as inhibitors of p38 kinase UA78578C2 (en)

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GBGB0214268.5A GB0214268D0 (en)	2002-06-20	2002-06-20	Chemical compounds
PCT/GB2003/002667 WO2004000846A1 (en)	2002-06-20	2003-06-20	Arylamine substututed bicyclic heteroaromatic compounds as p38 kinase inhibitors

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EP (1)	EP1551848A1 (es)
JP (1)	JP2005530838A (es)
KR (1)	KR20060013331A (es)
CN (1)	CN100390179C (es)
AU (1)	AU2003253087B2 (es)
BR (1)	BR0311842A (es)
CA (1)	CA2487718A1 (es)
EA (1)	EA008410B1 (es)
EC (1)	ECSP055560A (es)
GB (1)	GB0214268D0 (es)
IS (1)	IS7652A (es)
MX (1)	MXPA04012746A (es)
NO (1)	NO20050306L (es)
NZ (1)	NZ537740A (es)
PL (1)	PL375083A1 (es)
UA (1)	UA78578C2 (es)
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GB0601962D0 (en)	2006-01-31	2006-03-15	Ucb Sa	Therapeutic agents
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CA2726588C (en)	2008-06-03	2019-04-16	Karl Kossen	Compounds and methods for treating inflammatory and fibrotic disorders
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2002
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- 2003-06-20 WO PCT/GB2003/002667 patent/WO2004000846A1/en not_active Ceased
- 2003-06-20 EP EP03760802A patent/EP1551848A1/en not_active Withdrawn
- 2003-06-20 US US10/518,725 patent/US7423047B2/en not_active Expired - Fee Related
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Publication number	Publication date
PL375083A1 (en)	2005-11-14
EA008410B1 (ru)	2007-04-27
US20090042877A1 (en)	2009-02-12
US7763729B2 (en)	2010-07-27
EA200500042A1 (ru)	2005-08-25
IS7652A (is)	2005-01-18
NZ537740A (en)	2006-03-31
GB0214268D0 (en)	2002-07-31
AU2003253087A1 (en)	2004-01-06
CN100390179C (zh)	2008-05-28
ECSP055560A (es)	2005-05-30
NO20050306L (no)	2005-03-16
AU2003253087B2 (en)	2008-10-16
EP1551848A1 (en)	2005-07-13
US7423047B2 (en)	2008-09-09
JP2005530838A (ja)	2005-10-13
BR0311842A (pt)	2005-03-15
ZA200500524B (en)	2006-08-30
US20060004025A1 (en)	2006-01-05
KR20060013331A (ko)	2006-02-09
MXPA04012746A (es)	2005-03-23
CN1671715A (zh)	2005-09-21
CA2487718A1 (en)	2003-12-31
WO2004000846A1 (en)	2003-12-31

Publication	Publication Date	Title
UA78578C2 (en)	2007-04-10	Bicyclic heteroaromatic derivatives as inhibitors of p38 kinase
AU2002336172B2 (en)	2007-09-13	Bicyclic oxopyridine and oxopyrimidine derivatives
US7592455B2 (en)	2009-09-22	Bicyclic heteroaromatic compounds as kinase inhibitors
US7521460B2 (en)	2009-04-21	Thienopyridone derivatives as kinase inhibitors
AU2002336172A1 (en)	2003-07-03	Bicyclic oxopyridine and oxopyrimidine derivatives
CN104169260A (zh)	2014-11-26	新三嗪衍生物
US20110034495A1 (en)	2011-02-10	Method of Modulating Stress-Activated Protein Kinase System
AU2004249498A1 (en)	2004-12-29	Thienopyridone derivatives as kinase inhibitors
US7456286B2 (en)	2008-11-25	Bicyclic heteroaromatic compounds as kinase inhibitors
TWI327140B (en)	2010-07-11	Pyrimidine derivatives
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