ECSP055682A - NEW OXAZOL AND TIAZOL COMPOUNDS AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF) - Google Patents
NEW OXAZOL AND TIAZOL COMPOUNDS AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF)Info
- Publication number
- ECSP055682A ECSP055682A ECSP055682A ECSP055682A EC SP055682 A ECSP055682 A EC SP055682A EC SP055682 A ECSP055682 A EC SP055682A EC SP055682 A ECSP055682 A EC SP055682A
- Authority
- EC
- Ecuador
- Prior art keywords
- tgf
- compounds
- growth factor
- transforming growth
- new
- Prior art date
Links
- 102000009618 Transforming Growth Factors Human genes 0.000 title abstract 5
- 108010009583 Transforming Growth Factors Proteins 0.000 title abstract 5
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- -1 derivatives thereof Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 150000003557 thiazoles Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
. Se describen nuevos compuestos de oxazol y tiazol, incluyendo derivados de los mismos, intermedios para prepararlos, composiciones farmacéuticas que los contienen y su uso medicinal. Los compuestos de la presente invención son potentes inhibidores de la ruta de señalización del factor de crecimiento transformador ("TGF")-ß. Son útiles en el tratamiento de diversas patologías relacionadas con TGF incluyendo, por ejemplo, cáncer y enfermedades fibróticas. New oxazole and thiazole compounds, including derivatives thereof, intermediates for preparing them, pharmaceutical compositions containing them and their medicinal use are described. The compounds of the present invention are potent inhibitors of the signaling pathway of the transforming growth factor ("TGF") - ß. They are useful in the treatment of various pathologies related to TGF including, for example, cancer and fibrotic diseases
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41212002P | 2002-09-18 | 2002-09-18 | |
| US48458103P | 2003-07-02 | 2003-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP055682A true ECSP055682A (en) | 2005-05-30 |
Family
ID=40202989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP055682 ECSP055682A (en) | 2002-09-18 | 2005-03-17 | NEW OXAZOL AND TIAZOL COMPOUNDS AS INHIBITORS OF THE TRANSFORMING GROWTH FACTOR (TGF) |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP055682A (en) |
-
2005
- 2005-03-17 EC ECSP055682 patent/ECSP055682A/en unknown
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