ECSP055871A - Derivados de tetrahidroquinolina - Google Patents
Derivados de tetrahidroquinolinaInfo
- Publication number
- ECSP055871A ECSP055871A EC2005005871A ECSP055871A ECSP055871A EC SP055871 A ECSP055871 A EC SP055871A EC 2005005871 A EC2005005871 A EC 2005005871A EC SP055871 A ECSP055871 A EC SP055871A EC SP055871 A ECSP055871 A EC SP055871A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkoxy
- alkylamino
- derivatives
- heterocycloalkyl
- heteroaryl
- Prior art date
Links
- 150000003530 tetrahydroquinolines Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 9
- 125000003282 alkyl amino group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000004949 alkyl amino carbonyl amino group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004658 aryl carbonyl amino group Chemical group 0.000 abstract 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 125000005224 heteroarylcarbonylamino group Chemical group 0.000 abstract 1
- 125000005204 heteroarylcarbonyloxy group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000147 tetrahydroquinolinyl group Chemical class N1(CCCC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a derivados de tetrahidroquinolina de la fórmula general (I) o a su sal farmacéuticamente aceptable, en donde R1 y R2 son H o Me; R3 es H, hidroxi, (1-4C)alcoxi, (di)(1-4C)alquilamino(2-4C)alcoxi o (2-6)heterocicloalquil(2-4C)alcoxi; R4 es H, OH, (1-4C)alcoxi o R7; R5 es H, OH, (1-4C)alcoxi o R7, con la condición de que si R4 es H, R5 no es H, OH o (1-4C)alcoxi y si R5 es H, R4 no es H, OH o (1-4C)alcoxi; R6 es (2-5C)heteroarilo, (6C)arilo, (3-8)cicloalquilo, (2-6C)heterocicloalquilo o (1-6C)alquilo; R7 es amino, (di)(1-4C)alquilamino, (6C)arilcarbonilamino, (6C)arilcarboniloxi, (2-5C)heteroarilcarbonilamino, (2-5C)heteroarilcarboniloxi, R8-(2-4C)alquilamino, R8-(2-4C)alcoxi, R9-metilamino o R9-metoxi; R8 es hidroxi, amino, (1-4C)alcoxi, (di)(1-4C)alquilamino, (2-6C)heterocicloalquilo, (2-6C)heterocicloalquilcarbonilamino, (di)(1-4C)alquilaminocarbonilamino o (1-4C)alcoxicarbonilamino y R9 es aminocarbonilo, (di)(1-4C)alquilaminocarbonilo, (2-5C)heteroarilo o (6C)arilo. La presente invención también se refiere a composiciones farmacéuticas que comprenden dichos derivados y al uso de estos derivados para regular la fertilidad.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43504002P | 2002-12-20 | 2002-12-20 | |
| EP02102866 | 2002-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP055871A true ECSP055871A (es) | 2005-09-20 |
Family
ID=32683821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005005871A ECSP055871A (es) | 2002-12-20 | 2005-06-20 | Derivados de tetrahidroquinolina |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR20050084341A (es) |
| CO (1) | CO5590903A2 (es) |
| DE (1) | DE60326390D1 (es) |
| EC (1) | ECSP055871A (es) |
| EG (1) | EG24958A (es) |
| HR (1) | HRP20050576A2 (es) |
| IS (1) | IS2647B (es) |
| MX (1) | MXPA05006767A (es) |
| NO (1) | NO330612B1 (es) |
-
2003
- 2003-12-16 DE DE60326390T patent/DE60326390D1/de not_active Expired - Lifetime
- 2003-12-16 HR HR20050576A patent/HRP20050576A2/hr not_active Application Discontinuation
- 2003-12-16 KR KR1020057011089A patent/KR20050084341A/ko not_active Abandoned
- 2003-12-16 MX MXPA05006767A patent/MXPA05006767A/es active IP Right Grant
-
2005
- 2005-05-26 IS IS7871A patent/IS2647B/is unknown
- 2005-06-07 NO NO20052727A patent/NO330612B1/no not_active IP Right Cessation
- 2005-06-18 EG EGNA2005000309 patent/EG24958A/xx active
- 2005-06-20 EC EC2005005871A patent/ECSP055871A/es unknown
- 2005-07-19 CO CO05071364A patent/CO5590903A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20052727L (no) | 2005-07-13 |
| DE60326390D1 (en) | 2009-04-09 |
| CO5590903A2 (es) | 2005-12-30 |
| EG24958A (en) | 2011-02-28 |
| IS7871A (is) | 2005-05-26 |
| NO20052727D0 (no) | 2005-06-07 |
| KR20050084341A (ko) | 2005-08-26 |
| MXPA05006767A (es) | 2005-09-08 |
| HK1077577A1 (en) | 2006-02-17 |
| NO330612B1 (no) | 2011-05-30 |
| IS2647B (is) | 2010-08-15 |
| HRP20050576A2 (en) | 2005-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA81442C2 (en) | Tetrahydroquinoline derivatives | |
| ECSP034932A (es) | Derivados de tetrahidroquinolina | |
| ECSP055815A (es) | Composición para el tratamiento de la infección por virus flaviviridae | |
| AR036093A1 (es) | Compuestos derivados de tiazolidinilo, pirrolidinilo, oxazolidinilo, piperidilo, morfolinilo y tiomorfolinilo, su uso, composiciones farmaceuticas que los comprenden, y compuestos intermediarios | |
| ES2722409T3 (es) | Moduladores de ROR gamma (RORy) | |
| UA92083C2 (ru) | Азабициклические алкановые производные, замещенные конденсированным бициклогетероциклом | |
| WO2004056779A3 (en) | Tetrahydroquinoline derivatives and their use as fsh receptor modulators | |
| ME00555A (en) | Tryasolyl tropane derivatives as ccr5 modulators | |
| TW200738706A (en) | Pyrido-, pyrazo-and pyrimido-pyrimidine derivatives and their use as mTOR inhibitors | |
| EA200970478A1 (ru) | Аналоги тиофена для лечения или предупреждения флавивирусных инфекций | |
| HUP0302526A2 (hu) | Makrolid vegyületek, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| CO5580815A2 (es) | Derivados de adamantana, procesos para su preparacion y composiciones farmaceuticas que los contienen | |
| AR061008A1 (es) | Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo | |
| YU18999A (sh) | Supstituisani tricikli | |
| CR7950A (es) | Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas | |
| AR063979A1 (es) | Antagonistas de receptor de orexina de diazepam sustituidos | |
| BR0009558A (pt) | Composto derivado bicìclico heteroaromático, composição farmacêutica, e, uso de compostos derivados bicìclicos heteroaromáticos | |
| CO5200848A1 (es) | Derivados de 3(5)-ureido-pirazol, proceso para su prepa- racion y su utilizacion como agentes antitumorales | |
| PY0225352A (es) | Nuevos derivados de piperazina | |
| AR042346A1 (es) | Sales de aluminio poco irritantes y de alta eficacia y las composiciones antitranspirantes que las contienen | |
| AR046313A1 (es) | Compuesto de 2-cianopirrolidincarboxamida, un metodo para su obtencion y su empleo en composiciones farmaceuticas y en medicamentos con actividad inhibitoria de la dipeptidil peptidasa-iv (dpp-iv). | |
| AR075531A1 (es) | Derivados de piperazin-ciclopropil benzamidas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de trastornos del sistema nervioso central, tales como alzheimer y esquizofrenia, entre otros | |
| AR046753A1 (es) | Derivados de benzoxazina y usos de los mismos | |
| AR039319A1 (es) | Imidazolinilmetil aralquilsulfonamidas | |
| AR042284A1 (es) | Derivados de piperidina, preparacion y composiciones farmaceuticas que las contienen; y uso de los mismos para la fabricacion de medicamentos |