CR7950A - Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas - Google Patents

Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas

Info

Publication number
CR7950A
CR7950A CR7950A CR7950A CR7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A
Authority
CR
Costa Rica
Prior art keywords
preparation
cianoquinolines
2butenoil
4amino
chlorine
Prior art date
Application number
CR7950A
Other languages
English (en)
Inventor
Leo Considine John
Daigneault Sylvain
Chew Warren
Iera Silvio
Scott Duncan Mason
Ren Jianxin
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32825162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR7950(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR7950A publication Critical patent/CR7950A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invencion proporciona un compuesto de la formula (I) en donde S1 y S2 son cada uno independientemente hidrogeno, alquilo, alquelino, alquilino, aralquilo, arilo sustituido o no sustituido, y S1 y S2 conjuntamente con el nitrogeno al cual estos estan enlazados forman un heteroarilo que contiene nitrogeno y una sal farmaceuticamente aceptable del mismo; un metodo para la preparacion del compuesto de la formula (I) y el uso del compuesto de la formula (I) en la preparacion de las 3- cianoquinolinas.
CR7950A 2003-01-21 2005-08-19 Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas CR7950A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44147003P 2003-01-21 2003-01-21

Publications (1)

Publication Number Publication Date
CR7950A true CR7950A (es) 2006-05-30

Family

ID=32825162

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7950A CR7950A (es) 2003-01-21 2005-08-19 Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas

Country Status (15)

Country Link
US (1) US7126025B2 (es)
EP (1) EP1585479A2 (es)
CN (1) CN100537518C (es)
AR (1) AR042877A1 (es)
AU (1) AU2004207475A1 (es)
CA (1) CA2514550A1 (es)
CL (2) CL2004000016A1 (es)
CR (1) CR7950A (es)
EC (1) ECSP055974A (es)
MX (1) MXPA05008876A (es)
NO (1) NO20053890L (es)
RU (1) RU2345984C2 (es)
SG (1) SG166678A1 (es)
TW (1) TW200418763A (es)
WO (1) WO2004066919A2 (es)

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UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
CA2553729A1 (en) * 2004-01-16 2005-08-04 Wyeth Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
US7550598B2 (en) 2004-08-18 2009-06-23 Takeda Pharmaceutical Company Limited Kinase inhibitors
DE602005023333D1 (de) 2004-10-15 2010-10-14 Takeda Pharmaceutical Kinaseinhibitoren
CN108421044A (zh) 2005-02-03 2018-08-21 综合医院公司 治疗吉非替尼耐药性癌症的方法
RU2007140957A (ru) * 2005-05-25 2009-06-27 Вайет (Us) Способы синтеза производных 6-алкиламинохинолинов
BRPI0610147A2 (pt) * 2005-05-25 2010-06-01 Wyeth Corp método para preparar e sintetizar 3-cianoquinolinas substituìdas e 4-amino-3-cianoquinolinas
CN101180269A (zh) * 2005-05-25 2008-05-14 惠氏公司 制备3-氰基-喹啉的方法和由其制得的中间体
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
BRPI0618042A2 (pt) 2005-11-04 2011-08-16 Wyeth Corp usos de uma rapamicina e de uma herceptina, produto, pacote farmacêutico, e, composição farmacêutica
EP1948179A1 (en) 2005-11-11 2008-07-30 Boehringer Ingelheim International GmbH Quinazoline derivatives for the treatment of cancer diseases
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
CN102641270A (zh) 2008-06-17 2012-08-22 惠氏有限责任公司 含有hki-272和长春瑞滨的抗肿瘤组合
US8669273B2 (en) 2008-08-04 2014-03-11 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
WO2010048477A2 (en) * 2008-10-24 2010-04-29 Wyeth Llc Improved process for preparation of coupled products from 4-amino-3-cyanoquinolines using stabilized intermediates
CN102216256A (zh) * 2008-11-17 2011-10-12 诺瓦提斯公司 γ-氨基-α，β-不饱和羧酸衍生物的对映选择性合成
IL264349B2 (en) 2009-04-06 2024-01-01 Wyeth Llc Regimen comprising neratinib for the treatment of cancer
WO2010131921A2 (ko) * 2009-05-14 2010-11-18 코오롱생명과학 주식회사 알킬아민 유도체의 제조방법
PL2451445T3 (pl) 2009-07-06 2019-09-30 Boehringer Ingelheim International Gmbh Sposób suszenia BIBW2992, jego soli i stałych preparatów farmaceutycznych zawierających tę substancję czynną
NZ599762A (en) 2009-11-09 2014-07-25 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
CN102731395B (zh) * 2011-04-15 2015-02-04 中国科学院上海药物研究所 抗肿瘤药物来那替尼的中间体及其制备与应用
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN104926669A (zh) * 2014-03-18 2015-09-23 江苏豪森医药集团连云港宏创医药有限公司 反式-4-二甲基胺基巴豆酸盐酸盐的制备方法
WO2015186065A1 (en) 2014-06-02 2015-12-10 Sun Pharmaceutical Industries Limited Process for the preparation of 4-dimethylaminocrotonic acid
CN105439879B (zh) * 2014-08-07 2018-08-10 天津法莫西医药科技有限公司 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN105669479B (zh) * 2015-12-31 2018-04-13 重庆威鹏药业有限公司 一锅法制备高纯度反式‑4‑二甲基胺基巴豆酸盐酸盐的方法
BR112018071617A2 (pt) * 2016-04-28 2019-02-19 Jiangsu Hengrui Medicine Co., Ltd. método para preparar inibidor de tirosina quinase e derivado do mesmo
US11407734B2 (en) 2017-10-18 2022-08-09 Jiangsu Hengrui Medicine Co., Ltd. Preparation method for tyrosine kinase inhibitor and intermediate thereof
CN111217850B (zh) * 2019-01-31 2023-05-26 微宏先进材料公司 硅基酯类化合物制备方法、硅基酯类化合物、包含其的电解液及二次电池
CN112679473B (zh) * 2019-10-18 2024-03-05 四川科伦药物研究院有限公司 来那替尼中间体晶体、制备方法及其用途

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US4195021A (en) 1977-10-26 1980-03-25 Eli Lilly And Company 1,3-Disubstituted 2-azetidinone antibitotics
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DE3347659A1 (de) 1983-12-31 1985-07-11 Bayer Ag, 5090 Leverkusen Neue lackloesungen auf der basis von hydantoingruppen enthaltenden polymeren
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US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.

Also Published As

Publication number Publication date
RU2005126418A (ru) 2006-01-27
CL2007001286A1 (es) 2008-01-25
AR042877A1 (es) 2005-07-06
US7126025B2 (en) 2006-10-24
CN1761644A (zh) 2006-04-19
WO2004066919A2 (en) 2004-08-12
SG166678A1 (en) 2010-12-29
NO20053890D0 (no) 2005-08-19
ECSP055974A (es) 2006-01-16
RU2345984C2 (ru) 2009-02-10
US20040162442A1 (en) 2004-08-19
CL2004000016A1 (es) 2005-04-15
MXPA05008876A (es) 2005-10-05
CA2514550A1 (en) 2004-08-12
WO2004066919A3 (en) 2005-01-27
NO20053890L (no) 2005-10-20
EP1585479A2 (en) 2005-10-19
TW200418763A (en) 2004-10-01
AU2004207475A1 (en) 2004-08-12
CN100537518C (zh) 2009-09-09

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