CR7950A - Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas - Google Patents

Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas

Info

Publication number
CR7950A
CR7950A CR7950A CR7950A CR7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A
Authority
CR
Costa Rica
Prior art keywords
preparation
cianoquinolines
2butenoil
4amino
chlorine
Prior art date
Application number
CR7950A
Other languages
English (en)
Inventor
Leo Considine John
Daigneault Sylvain
Chew Warren
Iera Silvio
Scott Duncan Mason
Ren Jianxin
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32825162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR7950(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR7950A publication Critical patent/CR7950A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

La invencion proporciona un compuesto de la formula (I) en donde S1 y S2 son cada uno independientemente hidrogeno, alquilo, alquelino, alquilino, aralquilo, arilo sustituido o no sustituido, y S1 y S2 conjuntamente con el nitrogeno al cual estos estan enlazados forman un heteroarilo que contiene nitrogeno y una sal farmaceuticamente aceptable del mismo; un metodo para la preparacion del compuesto de la formula (I) y el uso del compuesto de la formula (I) en la preparacion de las 3- cianoquinolinas.
CR7950A 2003-01-21 2005-08-19 Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas CR7950A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44147003P 2003-01-21 2003-01-21

Publications (1)

Publication Number Publication Date
CR7950A true CR7950A (es) 2006-05-30

Family

ID=32825162

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7950A CR7950A (es) 2003-01-21 2005-08-19 Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas

Country Status (15)

Country Link
US (1) US7126025B2 (es)
EP (1) EP1585479A2 (es)
CN (1) CN100537518C (es)
AR (1) AR042877A1 (es)
AU (1) AU2004207475A1 (es)
CA (1) CA2514550A1 (es)
CL (2) CL2004000016A1 (es)
CR (1) CR7950A (es)
EC (1) ECSP055974A (es)
MX (1) MXPA05008876A (es)
NO (1) NO20053890L (es)
RU (1) RU2345984C2 (es)
SG (1) SG166678A1 (es)
TW (1) TW200418763A (es)
WO (1) WO2004066919A2 (es)

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UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
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US7572914B2 (en) 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
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WO2006023931A2 (en) 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
NZ556673A (en) 2005-02-03 2010-03-26 Gen Hospital Corp Method for treating gefitinib and/or erlotinib resistant cancer with an EGFR inhibitor
CN101203494A (zh) * 2005-05-25 2008-06-18 惠氏公司 合成经取代3-氰基喹啉和其中间物的方法
WO2006127205A2 (en) * 2005-05-25 2006-11-30 Wyeth Methods of preparing 3-cyano-quinolines and intermediates made thereby
RU2007140957A (ru) * 2005-05-25 2009-06-27 Вайет (Us) Способы синтеза производных 6-алкиламинохинолинов
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP3488866A1 (en) 2005-11-04 2019-05-29 Wyeth LLC Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
CA2833706C (en) 2005-11-11 2014-10-21 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
ES2531322T3 (es) 2008-06-17 2015-03-13 Wyeth Llc Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
EP3175853B1 (en) 2008-08-04 2023-11-01 Wyeth LLC Antineoplastic combinations of neratinib and capecitabine
WO2010048477A2 (en) * 2008-10-24 2010-04-29 Wyeth Llc Improved process for preparation of coupled products from 4-amino-3-cyanoquinolines using stabilized intermediates
JP2012508780A (ja) * 2008-11-17 2012-04-12 ノバルティス アーゲー γ−アミノ−α，β−不飽和カルボン酸誘導体のエナンチオ選択的合成
PT3000467T (pt) 2009-04-06 2023-03-30 Wyeth Llc Regime de tratamento utilizando neratinib para o cancro de mama
WO2010131921A2 (ko) * 2009-05-14 2010-11-18 코오롱생명과학 주식회사 알킬아민 유도체의 제조방법
SI2451445T1 (sl) 2009-07-06 2019-07-31 Boehringer Ingelheim International Gmbh Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino
EP2498751B1 (en) 2009-11-09 2019-04-03 Wyeth LLC Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
CN102731395B (zh) * 2011-04-15 2015-02-04 中国科学院上海药物研究所 抗肿瘤药物来那替尼的中间体及其制备与应用
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN104926669A (zh) * 2014-03-18 2015-09-23 江苏豪森医药集团连云港宏创医药有限公司 反式-4-二甲基胺基巴豆酸盐酸盐的制备方法
WO2015186065A1 (en) 2014-06-02 2015-12-10 Sun Pharmaceutical Industries Limited Process for the preparation of 4-dimethylaminocrotonic acid
CN105439879B (zh) * 2014-08-07 2018-08-10 天津法莫西医药科技有限公司 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN105669479B (zh) * 2015-12-31 2018-04-13 重庆威鹏药业有限公司 一锅法制备高纯度反式‑4‑二甲基胺基巴豆酸盐酸盐的方法
EP3447051B1 (en) * 2016-04-28 2021-12-15 Jiangsu Hengrui Medicine Co., Ltd. Method for preparing tyrosine kinase inhibitor and derivative thereof
WO2019076316A1 (zh) 2017-10-18 2019-04-25 江苏恒瑞医药股份有限公司 一种酪氨酸激酶抑制剂及其中间体的制备方法
CN111217850B (zh) * 2019-01-31 2023-05-26 微宏先进材料公司 硅基酯类化合物制备方法、硅基酯类化合物、包含其的电解液及二次电池
CN112679473B (zh) * 2019-10-18 2024-03-05 四川科伦药物研究院有限公司 来那替尼中间体晶体、制备方法及其用途

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US4195021A (en) * 1977-10-26 1980-03-25 Eli Lilly And Company 1,3-Disubstituted 2-azetidinone antibitotics
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
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UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.

Also Published As

Publication number Publication date
CL2007001286A1 (es) 2008-01-25
MXPA05008876A (es) 2005-10-05
CN100537518C (zh) 2009-09-09
CL2004000016A1 (es) 2005-04-15
SG166678A1 (en) 2010-12-29
NO20053890L (no) 2005-10-20
US20040162442A1 (en) 2004-08-19
CN1761644A (zh) 2006-04-19
AU2004207475A1 (en) 2004-08-12
AR042877A1 (es) 2005-07-06
RU2005126418A (ru) 2006-01-27
US7126025B2 (en) 2006-10-24
RU2345984C2 (ru) 2009-02-10
TW200418763A (en) 2004-10-01
ECSP055974A (es) 2006-01-16
CA2514550A1 (en) 2004-08-12
WO2004066919A3 (en) 2005-01-27
WO2004066919A2 (en) 2004-08-12
EP1585479A2 (en) 2005-10-19
NO20053890D0 (no) 2005-08-19

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