ECSP055899A - Pirimidinas inhibidoras de chk, pdk y akt, su producción y su uso como agentes farmacéuticos - Google Patents

Pirimidinas inhibidoras de chk, pdk y akt, su producción y su uso como agentes farmacéuticos

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Publication number
ECSP055899A
ECSP055899A EC2005005899A ECSP055899A ECSP055899A EC SP055899 A ECSP055899 A EC SP055899A EC 2005005899 A EC2005005899 A EC 2005005899A EC SP055899 A ECSP055899 A EC SP055899A EC SP055899 A ECSP055899 A EC SP055899A
Authority
EC
Ecuador
Prior art keywords
production
pyrimidins
pdk
chk
pharmaceutical agents
Prior art date
Application number
EC2005005899A
Other languages
English (en)
Inventor
Judi Bryant
Monica Kochanny
Shendong Yuan
Seock Kyu Khim
Brad Buckman
Damian Arnaiz
Ulf Bomer
Hans Briem
Peter Esperling
Christoph Huwe
Joachim Kuhnke
Martina Schafer
Lars Wortmann
Dirk Kosemund
Emil Eckle
Richard Feldman
Gary Phillips
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ECSP055899A publication Critical patent/ECSP055899A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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Abstract

Esta invención se relaciona con derivados de pirimidina de formula general (I) como inhibidores de quinasas, su producción y su uso como medicación para el tratamiento de diversas enfermedades.
EC2005005899A 2002-11-28 2005-06-28 Pirimidinas inhibidoras de chk, pdk y akt, su producción y su uso como agentes farmacéuticos ECSP055899A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02026607 2002-11-28

Publications (1)

Publication Number Publication Date
ECSP055899A true ECSP055899A (es) 2005-11-22

Family

ID=32338009

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005899A ECSP055899A (es) 2002-11-28 2005-06-28 Pirimidinas inhibidoras de chk, pdk y akt, su producción y su uso como agentes farmacéuticos

Country Status (20)

Country Link
US (1) US7504410B2 (es)
EP (1) EP1565446A1 (es)
JP (1) JP2006508997A (es)
KR (1) KR20050084027A (es)
CN (1) CN1717396A (es)
AU (1) AU2003288198A1 (es)
BR (1) BR0316680A (es)
CA (1) CA2502970A1 (es)
EA (1) EA200500721A1 (es)
EC (1) ECSP055899A (es)
HR (1) HRP20050601A2 (es)
IL (1) IL168102A0 (es)
IS (1) IS7881A (es)
MX (1) MXPA05005547A (es)
NO (1) NO20053144D0 (es)
NZ (1) NZ539823A (es)
PL (1) PL377795A1 (es)
RS (1) RS20050363A (es)
WO (1) WO2004048343A1 (es)
ZA (1) ZA200505184B (es)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0209774A (pt) * 2001-05-29 2004-06-01 Schering Ag Pirimidinas inibidoras de cdk, sua preparação e aplicação como medicamento
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ZA200505184B (en) 2006-09-27
NO20053144D0 (no) 2005-06-27
MXPA05005547A (es) 2005-07-26
BR0316680A (pt) 2005-10-18
IS7881A (is) 2005-06-02
US20040186118A1 (en) 2004-09-23
CA2502970A1 (en) 2004-06-10
EA200500721A1 (ru) 2005-12-29
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EP1565446A1 (en) 2005-08-24
KR20050084027A (ko) 2005-08-26
JP2006508997A (ja) 2006-03-16
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