ECSP055961A - Formulaciones parenterales de péptidos para el tratamiento de lupus eritematoso sistémico - Google Patents
Formulaciones parenterales de péptidos para el tratamiento de lupus eritematoso sistémicoInfo
- Publication number
- ECSP055961A ECSP055961A EC2005005961A ECSP055961A ECSP055961A EC SP055961 A ECSP055961 A EC SP055961A EC 2005005961 A EC2005005961 A EC 2005005961A EC SP055961 A ECSP055961 A EC SP055961A EC SP055961 A ECSP055961 A EC SP055961A
- Authority
- EC
- Ecuador
- Prior art keywords
- ala
- glu
- seq
- lys
- ser
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 3
- 206010025135 lupus erythematosus Diseases 0.000 title abstract 2
- 230000009885 systemic effect Effects 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 4
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 230000003172 anti-dna Effects 0.000 abstract 2
- 239000008135 aqueous vehicle Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 239000001116 FEMA 4028 Substances 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- BIYXEUAFGLTAEM-WUJLRWPWSA-N Thr-Gly Chemical compound C[C@@H](O)[C@H](N)C(=O)NCC(O)=O BIYXEUAFGLTAEM-WUJLRWPWSA-N 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- 229940113088 dimethylacetamide Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 108010061238 threonyl-glycine Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Marine Sciences & Fisheries (AREA)
- Rehabilitation Therapy (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
SUMARIO DE LA INVENCIÓN La presente invención provee una composición farmacéutica que comprende: Un vehículo acuoso de 0.1 mg/ml a 20 mg/ml de la composición de una sal farmacéuticamente aceptable de: a) un péptido que comprende por lo menos de 12 y a lo mucho 30 aminoácidos consecutivos que tiene una secuencia correspondiente a: i) una secuencia de aminoácidos encontrada dentro de una región determinante de complementariedad (CDR) de una cadena ligera o pesada de un anticuerpo 16/6 Id de un anti-ADN monoclonal humano,o ii) una secuencia de aminoácidos encontrada dentro de una región determinante de complementariedad (CDR) de una cadena ligera o pesada de un anticuerpo monoclonal anti-ADN patogénico que induce una respuesta en ratones de enfermedad similar a lupus sistémico eritematoso (SLE), o b) un péptido que comprende aminoácidos consecutivos que tienen la secuencia de: (i) TGYYX1X2X3X4X5QSPEKSLEWIG (SEC ID NO: 11) en donde X1 es Met, Ala o Val; X2 es Gln, Asp, Glu o Arg; X3 es Trp or Ala; X4 es Val o Ser; y X5 es Lys, Glu o Ala; (ii) EINPSTGGX6X7X8X9X10X11X12KAKAT (SEC ID NO:12) en donde X6 y X7 son cada Thr, Val o Ala; X8 es Tyr o Phe; X9 es Asn o Asp¸ X10 es Gln o Glu; X11 es Lys o Glu, y X12 es Phe o Tyr; (iii) YYCARX13X14X15X16X17X18YWGQGS (SEC ID NO : 13) en donde X13 es Phe, Thr o Gly; X14 es Leu, Ala o Ser; X15 es Trp o Ala; X16 es Glu o Lys; X17 es Met o Ala, y X18 es Asp, Lys o Ser; (iv) GYNX19X20X21X22X23X24X25X26LEWIG (SEC ID NO: 14)en donde X19 es Met o Ala; X20 es Asn, Asp o Arg; X21 es Trp o Ala; X22 es Val o Ser; X23 es Lys o Glu; X24 es Gln o Ala; X25 es Lys o Glu, y X26 es Ser o Ala; (v) YYCARX27X28X29YGX30X31X32GQTL (SEC ID NO: 15) en donde X27 es Ser o Phe; X28 es Gly o Ala; X29 es Arg, Ala o Glu; X30 es Asn o Asp; X31 es Tyr o Phe¸y X32 es Trp, His o Ala; (vi) X33YYWSWIX134QX35PX36X37GX38EWIG (SEC ID NO: 16) en donde X33 es Gly o Thr Gly; X34 es Arg o Lys; X35 es Pro o Ser; X36 es Gly o Glu; X37 es Lys o Asp; y X38 es Glu, Leu o Ser; (vii) YYCARX39LLX40X41X42X43X44DVDYX45GX46DV (SEC ID NO: 17) en donde X39 es Gly o Phe; X40 es Arg o Ala; X41 es Gly o Ala; X42 es Gly o Ala; X43 es Trp o Ala; X44 es Asn o Ala; X45 es Tyr o Trp; X46 es Met o Gln; (viii) FSGYYWS (SEC ID NO: 8); (ix) EINHSGSTNYKTSLKS (SEC ID NO: 9); o (x) GLLRGGWNDVDYYYGMDV (SEC ID NO: 10), o c) un péptido que comprende aminoácidos consecutivos que tienen una secuencia de cualquiera de a) y b), o por lo menos dos de las secuencias en (a) (i), (a) (ii) y (b) (i) hasta (b) (x), o d) un péptido que comprende aminoácidos consecutivos que tienen una secuencia que comprenpor lo menos de dos secuencias idénticas incluidas en (a) (i), (a) (ii) y (b) (i) hasta (b) (x); y un incrementador de solubilidad seleccionado del grupo que consiste de dimetil-acetamida, polietilenglicol, aceite de castos polioxilado, N-metil-2-pirrolidinona, 1-etenil-2-pirrolidinona, esteres de sorbitán de polioxietileno, y una ß-ciclodextrina substituida, en donde tanto el péptido como el incrementador de solubilidad se disuelven en un vehículo acuoso; y en donde la composición tiene un pH entre 4 y 9. La presente invención también provee un método para aliviar los síntomas del lupus sistémico eritematoso (SLE) en un sujeto humano que comprende administrar al sujeto humano cualquiera de las composiciones farmacéuticas de la invención en una cantidad efectiva para aliviar los síntomas de SLE en el sujeto humano.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43991803P | 2003-01-14 | 2003-01-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP055961A true ECSP055961A (es) | 2006-04-19 |
Family
ID=32771757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005005961A ECSP055961A (es) | 2003-01-14 | 2005-08-11 | Formulaciones parenterales de péptidos para el tratamiento de lupus eritematoso sistémico |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20050008634A1 (es) |
| EP (1) | EP1594434B1 (es) |
| JP (2) | JP4817068B2 (es) |
| KR (1) | KR20050100617A (es) |
| CN (1) | CN1774259B (es) |
| AU (1) | AU2004206842A1 (es) |
| BR (1) | BRPI0406745A (es) |
| CA (1) | CA2513320C (es) |
| CO (1) | CO5640143A2 (es) |
| CR (1) | CR7938A (es) |
| DK (1) | DK1594434T3 (es) |
| EA (1) | EA009123B1 (es) |
| EC (1) | ECSP055961A (es) |
| ES (1) | ES2606464T3 (es) |
| IL (1) | IL169574A (es) |
| IS (1) | IS7972A (es) |
| MX (1) | MXPA05007549A (es) |
| NO (1) | NO20053773L (es) |
| NZ (1) | NZ541658A (es) |
| WO (1) | WO2004064787A2 (es) |
| ZA (1) | ZA200506206B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL141647A0 (en) * | 2001-02-26 | 2002-03-10 | Yeda Res & Dev | Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus |
| US20050008634A1 (en) * | 2003-01-14 | 2005-01-13 | Sharon Cohen-Vered | Parenteral formulations of peptides for the treatment of systemic lupus erythematosus |
| UA83816C2 (ru) * | 2003-01-14 | 2008-08-26 | Тева Фармасьютикал Индастриз, Лтд | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ СОДЕРЖИТ ПЕПТИД И ЗАМЕЩЕННЫЙ β-ЦИКЛОДЕКСТРИН, ДЛЯ ЛЕЧЕНИЯ СИСТЕМНОЙ КРАСНОЙ ВОЛЧАНКИ |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| AR074357A1 (es) * | 2008-11-17 | 2011-01-12 | Genentech Inc | Metodo y formulacion para reducir la agregacion de una macromolecula bajo condiciones fisiologicas. metodo de dialisis in vitro |
| WO2013123254A1 (en) | 2012-02-15 | 2013-08-22 | Cydex Pharmaceuticals, Inc. | Manufacturing process for cyclodextrin derivatives |
| CN104470500A (zh) * | 2012-07-12 | 2015-03-25 | 赛诺菲 | 包含1-(6-{[6-(4-氟苯基)[1,2,4]三唑并[4,3-b]哒嗪-3-基]硫基}-1,3-苯并噻唑-2-基)-3-(2-吗啉-4-基乙基)尿素化合物的抗肿瘤组合物 |
| HK1213585A1 (zh) | 2012-10-22 | 2016-07-08 | Cydex Pharmaceuticals, Inc. | 烷基化环糊精组合物及其制备和使用方法 |
| WO2014193611A1 (en) * | 2013-05-29 | 2014-12-04 | Oklahoma Medical Research Foundation | Bright/arid3a function/expression as a marker for systemic lupus erythematosus severity and intensity |
| US10189881B2 (en) | 2013-07-26 | 2019-01-29 | The Regents Of The University Of California | MPS peptides and use thereof |
| US10314889B2 (en) * | 2013-12-20 | 2019-06-11 | The Regents Of The University Of California | Suppression of allergic lung inflammation and hyperreactivity |
| EP3183295B1 (en) | 2014-08-22 | 2023-08-02 | CyDex Pharmaceuticals, Inc. | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
| IL299759A (en) | 2015-12-30 | 2023-03-01 | Genentech Inc | Formulations with reduced polysorbate dissolution |
| TWI797073B (zh) | 2016-01-25 | 2023-04-01 | 德商安美基研究（慕尼黑）公司 | 包含雙特異性抗體建構物之醫藥組合物 |
| AU2018205885A1 (en) * | 2017-01-05 | 2019-06-27 | Yeda Research And Development Co. Ltd. | Peptides for treating Sjogren's syndrome |
| EP3608615A4 (en) * | 2017-04-04 | 2021-01-20 | Nitto Denko Corporation | LYOPHILIZED BODY MANUFACTURING PROCESS AND ITS MANUFACTURING DEVICE |
| US10975121B2 (en) | 2017-06-24 | 2021-04-13 | Cytogel Pharma, Llc | Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof |
| CN111683654A (zh) * | 2017-11-30 | 2020-09-18 | 细胞凝胶制药有限责任公司 | 新型镇痛药物制剂及其用途 |
| CN112143707A (zh) * | 2020-09-29 | 2020-12-29 | 广东先康达生物科技有限公司 | 一种治疗自身免疫细胞的免疫细胞及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60184098A (ja) * | 1984-03-02 | 1985-09-19 | Suntory Ltd | 新規なペプチド及びこれを有効成分とする利尿剤 |
| US6407079B1 (en) * | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
| US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
| US5126249A (en) * | 1989-05-09 | 1992-06-30 | Eli Lilly And Company | Enzymatic removal of a protein amino-terminal sequence |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| GB9200247D0 (en) * | 1992-01-07 | 1992-02-26 | Erba Carlo Spa | Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation |
| US5646131A (en) * | 1994-02-22 | 1997-07-08 | The Arab Company For Drug Industries And Medical Applicances (Acdima) | Method for solubilizing drugs using cyclodextrins and carboxylic acids |
| IL113159A0 (en) * | 1995-03-28 | 1995-06-29 | Yeda Res & Dev | Synthetic peptides and pharmaceutical compositions comprising them |
| US6613536B1 (en) * | 1995-03-28 | 2003-09-02 | Yeda Research And Development Co. Ltd. | Synthetic peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus |
| IL120503A0 (en) * | 1997-03-20 | 1997-07-13 | Hadasit Med Res Service | Peptides for the treatment of systemic lupus erythematosis and pharmaceutical compositions containing them |
| US20020054872A1 (en) * | 1997-03-20 | 2002-05-09 | Yaakov Naparstek | Peptides for the treatment of systemic lupus erythematosus and methods of treating systemic lupus erythematosus |
| SE9802938D0 (sv) * | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
| IL141647A0 (en) * | 2001-02-26 | 2002-03-10 | Yeda Res & Dev | Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus |
| US20050008634A1 (en) * | 2003-01-14 | 2005-01-13 | Sharon Cohen-Vered | Parenteral formulations of peptides for the treatment of systemic lupus erythematosus |
| UA83816C2 (ru) * | 2003-01-14 | 2008-08-26 | Тева Фармасьютикал Индастриз, Лтд | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ СОДЕРЖИТ ПЕПТИД И ЗАМЕЩЕННЫЙ β-ЦИКЛОДЕКСТРИН, ДЛЯ ЛЕЧЕНИЯ СИСТЕМНОЙ КРАСНОЙ ВОЛЧАНКИ |
| US7018891B2 (en) * | 2003-12-16 | 2006-03-28 | International Business Machines Corporation | Ultra-thin Si channel CMOS with improved series resistance |
-
2004
- 2004-01-14 US US10/758,397 patent/US20050008634A1/en not_active Abandoned
- 2004-01-14 EA EA200501131A patent/EA009123B1/ru not_active IP Right Cessation
- 2004-01-14 WO PCT/US2004/000948 patent/WO2004064787A2/en not_active Ceased
- 2004-01-14 NZ NZ541658A patent/NZ541658A/en unknown
- 2004-01-14 CN CN2004800069872A patent/CN1774259B/zh not_active Expired - Lifetime
- 2004-01-14 EP EP04702215.7A patent/EP1594434B1/en not_active Expired - Lifetime
- 2004-01-14 BR BR0406745-2A patent/BRPI0406745A/pt not_active IP Right Cessation
- 2004-01-14 JP JP2006500956A patent/JP4817068B2/ja not_active Expired - Fee Related
- 2004-01-14 MX MXPA05007549A patent/MXPA05007549A/es not_active Application Discontinuation
- 2004-01-14 CA CA2513320A patent/CA2513320C/en not_active Expired - Lifetime
- 2004-01-14 AU AU2004206842A patent/AU2004206842A1/en not_active Abandoned
- 2004-01-14 KR KR1020057013098A patent/KR20050100617A/ko not_active Withdrawn
- 2004-01-14 DK DK04702215.7T patent/DK1594434T3/da active
- 2004-01-14 ES ES04702215.7T patent/ES2606464T3/es not_active Expired - Lifetime
-
2005
- 2005-07-06 IL IL169574A patent/IL169574A/en active IP Right Grant
- 2005-08-03 ZA ZA200506206A patent/ZA200506206B/en unknown
- 2005-08-05 IS IS7972A patent/IS7972A/is unknown
- 2005-08-08 NO NO20053773A patent/NO20053773L/no not_active Application Discontinuation
- 2005-08-09 CR CR7938A patent/CR7938A/es not_active Application Discontinuation
- 2005-08-10 CO CO05079328A patent/CO5640143A2/es not_active Application Discontinuation
- 2005-08-11 EC EC2005005961A patent/ECSP055961A/es unknown
-
2008
- 2008-11-10 US US12/291,439 patent/US20090169559A1/en not_active Abandoned
-
2011
- 2011-03-24 JP JP2011066343A patent/JP2011173888A/ja active Pending
-
2012
- 2012-04-23 US US13/453,979 patent/US20130023485A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1774259A (zh) | 2006-05-17 |
| JP2011173888A (ja) | 2011-09-08 |
| WO2004064787A3 (en) | 2005-12-15 |
| JP4817068B2 (ja) | 2011-11-16 |
| IS7972A (is) | 2006-07-15 |
| CA2513320C (en) | 2018-03-27 |
| CA2513320A1 (en) | 2004-08-05 |
| WO2004064787A2 (en) | 2004-08-05 |
| NZ541658A (en) | 2008-04-30 |
| ZA200506206B (en) | 2006-12-27 |
| CN1774259B (zh) | 2011-12-28 |
| ES2606464T3 (es) | 2017-03-24 |
| CO5640143A2 (es) | 2006-05-31 |
| DK1594434T3 (da) | 2017-01-02 |
| EP1594434A2 (en) | 2005-11-16 |
| KR20050100617A (ko) | 2005-10-19 |
| IL169574A (en) | 2015-08-31 |
| IL169574A0 (en) | 2007-07-04 |
| NO20053773L (no) | 2005-10-12 |
| EP1594434B1 (en) | 2016-09-07 |
| EA200501131A1 (ru) | 2006-04-28 |
| US20090169559A1 (en) | 2009-07-02 |
| JP2006517540A (ja) | 2006-07-27 |
| EP1594434A4 (en) | 2008-09-10 |
| NO20053773D0 (no) | 2005-08-08 |
| BRPI0406745A (pt) | 2005-12-20 |
| US20050008634A1 (en) | 2005-01-13 |
| AU2004206842A1 (en) | 2004-08-05 |
| EA009123B1 (ru) | 2007-10-26 |
| CR7938A (es) | 2006-05-31 |
| US20130023485A1 (en) | 2013-01-24 |
| MXPA05007549A (es) | 2006-05-19 |
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