ECSP056091A - Proceso para la preparacion del analogo de ciclosporina a - Google Patents

Proceso para la preparacion del analogo de ciclosporina a

Info

Publication number
ECSP056091A
ECSP056091A EC2005006091A ECSP056091A ECSP056091A EC SP056091 A ECSP056091 A EC SP056091A EC 2005006091 A EC2005006091 A EC 2005006091A EC SP056091 A ECSP056091 A EC SP056091A EC SP056091 A ECSP056091 A EC SP056091A
Authority
EC
Ecuador
Prior art keywords
preparation
cyclosporin
cyclosporine analog
analogue
formula
Prior art date
Application number
EC2005006091A
Other languages
English (en)
Inventor
Jean-Michel Adam
Mark Abel
Seetharaman Jayaraman
Original Assignee
Isotechnika Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika Inc filed Critical Isotechnika Inc
Publication of ECSP056091A publication Critical patent/ECSP056091A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

El presente invento se relaciona con un nuevo proceso para la preparación de análogo de la ciclosporina A de la formula I: que comprende los pasos de, a) alicatar un aldehído protegido de ciclosporina A con un reactivo alilmetálico y, b) transformar el compuesto obtenido en el paso a) al análogo de la ciclosporina A de la fórmula I.
EC2005006091A 2003-04-08 2005-10-07 Proceso para la preparacion del analogo de ciclosporina a ECSP056091A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03007921 2003-04-08

Publications (1)

Publication Number Publication Date
ECSP056091A true ECSP056091A (es) 2006-03-01

Family

ID=33155122

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006091A ECSP056091A (es) 2003-04-08 2005-10-07 Proceso para la preparacion del analogo de ciclosporina a

Country Status (18)

Country Link
US (1) US20040220091A1 (es)
EP (1) EP1613646A2 (es)
JP (1) JP2006525961A (es)
KR (1) KR20050119200A (es)
CN (1) CN1798759A (es)
AU (1) AU2004228159A1 (es)
BR (1) BRPI0409734A (es)
CA (1) CA2521116A1 (es)
CO (1) CO5680450A2 (es)
EC (1) ECSP056091A (es)
MA (1) MA27831A1 (es)
MX (1) MXPA05010794A (es)
NO (1) NO20054478L (es)
RU (1) RU2005130508A (es)
TN (1) TNSN05255A1 (es)
TW (1) TW200505946A (es)
WO (1) WO2004089960A2 (es)
ZA (1) ZA200507980B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6859799B1 (en) 1998-11-30 2005-02-22 Gemstar Development Corporation Search engine for video and graphics
US7103906B1 (en) 2000-09-29 2006-09-05 International Business Machines Corporation User controlled multi-device media-on-demand system
ES2312475T3 (es) 2000-10-11 2009-03-01 United Video Properties, Inc. Sistemas y metodos para proporcionar el almacenamiento de datos en servidores de un sistema de entrega de medios bajo demanda.
US7493646B2 (en) 2003-01-30 2009-02-17 United Video Properties, Inc. Interactive television systems with digital video recording and adjustable reminders
US7538084B2 (en) 2003-03-17 2009-05-26 Amr Technology, Inc. Cyclosporins
US7799756B2 (en) * 2004-07-29 2010-09-21 Albany Molecular Research, Inc. Processes for stereoselective synthesis of trans ISATX247
US8086575B2 (en) 2004-09-23 2011-12-27 Rovi Solutions Corporation Methods and apparatus for integrating disparate media formats in a networked media system
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008514702A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
JP2008515886A (ja) 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
KR100780718B1 (ko) 2004-12-28 2007-12-26 엘지.필립스 엘시디 주식회사 도포액 공급장치를 구비한 슬릿코터
US8607287B2 (en) 2005-12-29 2013-12-10 United Video Properties, Inc. Interactive media guidance system having multiple devices
US9681105B2 (en) 2005-12-29 2017-06-13 Rovi Guides, Inc. Interactive media guidance system having multiple devices
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US20090019492A1 (en) 2007-07-11 2009-01-15 United Video Properties, Inc. Systems and methods for mirroring and transcoding media content
ES2667945T3 (es) 2007-10-08 2018-05-16 Aurinia Pharmaceuticals Inc. Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR
US8601526B2 (en) 2008-06-13 2013-12-03 United Video Properties, Inc. Systems and methods for displaying media content and media guidance information
FR2934997B1 (fr) * 2008-08-14 2010-09-24 Minakem Derives cyclopropyl-et cyclobutyl-dioxazaborocanes ou dioxazaborecanes
EP2440185B1 (en) 2009-06-09 2015-04-08 Aurinia Pharmaceuticals Inc. Topical drug delivery systems for ophthalmic use
US9014546B2 (en) 2009-09-23 2015-04-21 Rovi Guides, Inc. Systems and methods for automatically detecting users within detection regions of media devices
BR112013014890B1 (pt) 2010-12-15 2023-10-24 Contravir Pharmaceuticals, Inc Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos
US8805418B2 (en) 2011-12-23 2014-08-12 United Video Properties, Inc. Methods and systems for performing actions based on location-based rules
AR090964A1 (es) 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
US9674563B2 (en) 2013-11-04 2017-06-06 Rovi Guides, Inc. Systems and methods for recommending content
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
EP4201952A1 (en) 2021-12-21 2023-06-28 Curia Spain, S.A.U. Process for the controlled synthesis of voclosporin
WO2025119925A1 (en) 2023-12-05 2025-06-12 Medichem, S.A. Process for preparing voclosporin
IT202300028041A1 (it) * 2023-12-27 2025-06-27 Indena Spa Processo per la preparazione di voclosporina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3884470T2 (de) * 1987-06-17 1994-03-10 Sandoz Ag Cyclosporine und deren Benutzung als Arzneimittel.
AU7267298A (en) * 1997-04-30 1998-11-24 Regents Of The University Of California, The Synthesis of discodermolide and analogs
AU750245B2 (en) * 1997-10-08 2002-07-11 Aurinia Phamaceuticals Inc. Deuterated cyclosporine analogs and their use as immunomodulating agents
DE10143979A1 (de) * 2001-09-07 2003-03-27 Clariant Gmbh Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
MXPA04003625A (es) * 2001-10-19 2004-12-02 Sotechnika Inc Sintesis de analogos de ciclosporina.
CN100344648C (zh) * 2001-10-19 2007-10-24 伊索泰克尼卡股份有限公司 环孢菌素类似物混合物及其在制备免疫调节剂中的用途

Also Published As

Publication number Publication date
CO5680450A2 (es) 2006-09-29
WO2004089960A3 (en) 2005-01-06
TNSN05255A1 (en) 2007-07-10
CN1798759A (zh) 2006-07-05
RU2005130508A (ru) 2006-06-27
NO20054478D0 (no) 2005-09-28
CA2521116A1 (en) 2004-10-21
MA27831A1 (fr) 2006-04-03
WO2004089960A2 (en) 2004-10-21
EP1613646A2 (en) 2006-01-11
MXPA05010794A (es) 2005-12-14
TW200505946A (en) 2005-02-16
BRPI0409734A (pt) 2006-05-09
JP2006525961A (ja) 2006-11-16
ZA200507980B (en) 2006-11-29
NO20054478L (no) 2005-10-17
US20040220091A1 (en) 2004-11-04
AU2004228159A1 (en) 2004-10-21
KR20050119200A (ko) 2005-12-20

Similar Documents

Publication Publication Date Title
ECSP056091A (es) Proceso para la preparacion del analogo de ciclosporina a
BR112012014082A2 (pt) composições e métodos que compreendem variantes de protease
CO6280399A2 (es) Peptidil nitrilos y uso de los mismos como inhibidores de peptidil peptidasa i
ECSP11010812A (es) Complejo de mineral-aminoácido polisacárido
PY09026846A (es) Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
ATE528989T1 (de) Kristalline feste rasagilin-base
ECSP099721A (es) Inhibidores de cinasa p70 s6
HN2008001723A (es) Nitrilos espirociclicos como inhibidores de proteasa
UY28745A1 (es) Nuevos compuestos
CR20110240A (es) Inhibidores de cinasa akt y p70 s6
EA201401193A1 (ru) Триарильные соединения и композиции, их содержащие
BR112012011328A2 (pt) inibidores de akt
ECSP055671A (es) Nuevas quinazolinonas espirocondensadas y su uso como inhibidores de la fosfodiesteresa
CR8824A (es) Derivados de 2-carbamida-4-feniltiazol, su preparacion y su aplicacion en terapeutica
ECSP099616A (es) Estabilización de vitamina b12
MA29368B1 (fr) Formes posologiques resistant a l'extraction alcoolique
BRPI0713031B8 (pt) composto de di-hidro-piran-2-ona, composição farmacêutica, e uso dos mesmos
AR064955A1 (es) Composicion y metodo para estabilizar ingredientes sensibles
UY31103A1 (es) Composiciones farmaceuticas en base a microparticulas comprendiendo un analogo de somatostatina, proceso de preparacion y aplicaciones
UY30451A1 (es) 18-metil-19-nor-androst-4-en-17,17-espiroéteres (18-metil-19-nor-20-espirox-4-en-3-onas),ase como preparaciones farmacéuticas que lo contienen.
BRPI0408848B8 (pt) composições farmacêuticas de complexo de ciclodextrina-cladribina complexo, usos do referido complexo, bem como processos para a sua preparação
EA200600590A1 (ru) Фармацевтические композиции модафинила с модифицированным высвобождением
CL2009001342A1 (es) Pregn-4-en-21,17-carbolactonas sustituidas en el anillo c; preparados farmaceuticos que lo contienen; compuesto 11 alfa-hidroxi-15 beta, 16 beta-metilen-androst-4-en-3,17-diona; procedimiento para preparar dicho compuesto que comprende el uso de microorganismos.
BRPI0508102A (pt) inibidores de caspase e usos dos mesmos
GT200500358A (es) Compuestos organicos