MA27831A1 - Procede pour preparer un analogue de la cyclosporine a - Google Patents

Procede pour preparer un analogue de la cyclosporine a

Info

Publication number
MA27831A1
MA27831A1 MA28540A MA28540A MA27831A1 MA 27831 A1 MA27831 A1 MA 27831A1 MA 28540 A MA28540 A MA 28540A MA 28540 A MA28540 A MA 28540A MA 27831 A1 MA27831 A1 MA 27831A1
Authority
MA
Morocco
Prior art keywords
cyclosporin
analogue
preparing
formula
allylmetal
Prior art date
Application number
MA28540A
Other languages
English (en)
Inventor
Jean-Michel Adam
Mark Abel
Seetharaman Jayaraman
Original Assignee
Isotechnika Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika Inc filed Critical Isotechnika Inc
Publication of MA27831A1 publication Critical patent/MA27831A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention se rapporte à un nouveau procédé pour la préparation d'un analogue cyclosporine A de la formule I comprenant a) allylation d'un aldéhyde de cyclosporine A protégé avec un réactif allylemétal et b) conversion du composé obtenu à l'étape a) en analogue cyclosporine A de la formule I.
MA28540A 2003-04-08 2005-10-07 Procede pour preparer un analogue de la cyclosporine a MA27831A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03007921 2003-04-08

Publications (1)

Publication Number Publication Date
MA27831A1 true MA27831A1 (fr) 2006-04-03

Family

ID=33155122

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28540A MA27831A1 (fr) 2003-04-08 2005-10-07 Procede pour preparer un analogue de la cyclosporine a

Country Status (18)

Country Link
US (1) US20040220091A1 (fr)
EP (1) EP1613646A2 (fr)
JP (1) JP2006525961A (fr)
KR (1) KR20050119200A (fr)
CN (1) CN1798759A (fr)
AU (1) AU2004228159A1 (fr)
BR (1) BRPI0409734A (fr)
CA (1) CA2521116A1 (fr)
CO (1) CO5680450A2 (fr)
EC (1) ECSP056091A (fr)
MA (1) MA27831A1 (fr)
MX (1) MXPA05010794A (fr)
NO (1) NO20054478L (fr)
RU (1) RU2005130508A (fr)
TN (1) TNSN05255A1 (fr)
TW (1) TW200505946A (fr)
WO (1) WO2004089960A2 (fr)
ZA (1) ZA200507980B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6859799B1 (en) 1998-11-30 2005-02-22 Gemstar Development Corporation Search engine for video and graphics
US7103906B1 (en) 2000-09-29 2006-09-05 International Business Machines Corporation User controlled multi-device media-on-demand system
KR100971696B1 (ko) 2000-10-11 2010-07-22 유나이티드 비디오 프로퍼티즈, 인크. 데이터의 기억 장치를 주문형 매체 배달 시스템의 서버에 제공하기 위한 시스템 및 방법
US7493646B2 (en) 2003-01-30 2009-02-17 United Video Properties, Inc. Interactive television systems with digital video recording and adjustable reminders
EP1603512A2 (fr) 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Nouvelles cyclosporines
WO2006014872A2 (fr) * 2004-07-29 2006-02-09 Amr Technology, Inc. Nouveaux procedes de synthese stereoselective d'un compose isatx247 trans
US8086575B2 (en) 2004-09-23 2011-12-27 Rovi Solutions Corporation Methods and apparatus for integrating disparate media formats in a networked media system
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
KR100780718B1 (ko) 2004-12-28 2007-12-26 엘지.필립스 엘시디 주식회사 도포액 공급장치를 구비한 슬릿코터
US8607287B2 (en) 2005-12-29 2013-12-10 United Video Properties, Inc. Interactive media guidance system having multiple devices
US9681105B2 (en) 2005-12-29 2017-06-13 Rovi Guides, Inc. Interactive media guidance system having multiple devices
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US20090019492A1 (en) 2007-07-11 2009-01-15 United Video Properties, Inc. Systems and methods for mirroring and transcoding media content
AU2008310956B2 (en) 2007-10-08 2014-08-07 Aurinia Pharmaceuticals Inc. Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors
US8601526B2 (en) 2008-06-13 2013-12-03 United Video Properties, Inc. Systems and methods for displaying media content and media guidance information
FR2934997B1 (fr) * 2008-08-14 2010-09-24 Minakem Derives cyclopropyl-et cyclobutyl-dioxazaborocanes ou dioxazaborecanes
AU2010259184B2 (en) 2009-06-09 2015-08-13 Aurinia Pharmaceuticals Inc. Topical drug delivery systems for ophthalmic use
US9014546B2 (en) 2009-09-23 2015-04-21 Rovi Guides, Inc. Systems and methods for automatically detecting users within detection regions of media devices
MY165152A (en) 2010-12-15 2018-02-28 Contravir Pharmaceuticals Inc Cyclosporine analogue molecules modified at amino acid 1 and 3
US8805418B2 (en) 2011-12-23 2014-08-12 United Video Properties, Inc. Methods and systems for performing actions based on location-based rules
AR090964A1 (es) 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
US9674563B2 (en) 2013-11-04 2017-06-06 Rovi Guides, Inc. Systems and methods for recommending content
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
EP4201952A1 (fr) 2021-12-21 2023-06-28 Curia Spain, S.A.U. Procédé de synthèse contrôlée de voclosporine
WO2025119925A1 (fr) 2023-12-05 2025-06-12 Medichem, S.A. Procédé de préparation de voclosporine
IT202300028041A1 (it) 2023-12-27 2025-06-27 Indena Spa Processo per la preparazione di voclosporina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE95193T1 (de) * 1987-06-17 1993-10-15 Sandoz Ag Cyclosporine und deren benutzung als arzneimittel.
WO1998048791A1 (fr) * 1997-04-30 1998-11-05 The Regents Of The University Of California Synthese de discodermolide et analogues
ATE314388T1 (de) * 1997-10-08 2006-01-15 Isotechnika Inc Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien
DE10143979A1 (de) * 2001-09-07 2003-03-27 Clariant Gmbh Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
BRPI0213658A8 (pt) * 2001-10-19 2016-12-06 F Hoffmann La Roche Ltd Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
ES2310604T3 (es) * 2001-10-19 2009-01-16 Isotechnika, Inc. Mezclas de analogos de ciclosporinas y su uso como agentes inmunomoduladores.

Also Published As

Publication number Publication date
TW200505946A (en) 2005-02-16
ECSP056091A (es) 2006-03-01
US20040220091A1 (en) 2004-11-04
WO2004089960A2 (fr) 2004-10-21
CO5680450A2 (es) 2006-09-29
BRPI0409734A (pt) 2006-05-09
KR20050119200A (ko) 2005-12-20
NO20054478L (no) 2005-10-17
TNSN05255A1 (en) 2007-07-10
JP2006525961A (ja) 2006-11-16
CN1798759A (zh) 2006-07-05
AU2004228159A1 (en) 2004-10-21
WO2004089960A3 (fr) 2005-01-06
EP1613646A2 (fr) 2006-01-11
MXPA05010794A (es) 2005-12-14
NO20054478D0 (no) 2005-09-28
RU2005130508A (ru) 2006-06-27
CA2521116A1 (fr) 2004-10-21
ZA200507980B (en) 2006-11-29

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