ECSP066321A - Análogos de 4-(metilsulfonilamino) fenilo como antagonistas vanilloides que muestran excelente actividad analgésica y composiciones farmacéuticas que comprenden los mismos - Google Patents

Análogos de 4-(metilsulfonilamino) fenilo como antagonistas vanilloides que muestran excelente actividad analgésica y composiciones farmacéuticas que comprenden los mismos

Info

Publication number
ECSP066321A
ECSP066321A EC2006006321A ECSP066321A ECSP066321A EC SP066321 A ECSP066321 A EC SP066321A EC 2006006321 A EC2006006321 A EC 2006006321A EC SP066321 A ECSP066321 A EC SP066321A EC SP066321 A ECSP066321 A EC SP066321A
Authority
EC
Ecuador
Prior art keywords
pain
pharmaceutical compositions
same
analogs
disease
Prior art date
Application number
EC2006006321A
Other languages
English (en)
Inventor
Jee Woo Lee
Young Ho Kim
Hee Kim
Hyun Kyung Choi
Hee Jin Ha
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of ECSP066321A publication Critical patent/ECSP066321A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/14—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a análogos novedosos de 4-(metilsulfonilamino)fenilo como potentes antagonistas del receptor vanilloide y las composiciones farmacéuticas que comprenden los mismos. El compuesto de la invención puede resultar útil para analgésicos para prevenir, aliviar o tratar enfermedades con dolor o enfermedades inflamatorias que comprenden dolor, dolor agudo, dolor crónico, dolor neuropático, dolor posoperatorio, migraña, artralgia, neuropatías, lesión nerviosa, neuropatía diabética, neurodegeneración, trastorno neurótico de la piel, accidente cerebrovascular, hipersensibilidad de la vejiga urinaria, síndrome del intestino irritable, un trastorno respiratorio tal como asma o enfermedad pulmonar obstructiva crónica, irritación de la piel, ojos o membrana mucosa, fiebre, úlcera gastroduodenal, enfermedad inflamatoria del intestino, enfermedad inflamatoria e incontinencia urinaria urgente.
EC2006006321A 2003-07-02 2006-01-26 Análogos de 4-(metilsulfonilamino) fenilo como antagonistas vanilloides que muestran excelente actividad analgésica y composiciones farmacéuticas que comprenden los mismos ECSP066321A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20030044552 2003-07-02

Publications (1)

Publication Number Publication Date
ECSP066321A true ECSP066321A (es) 2006-07-28

Family

ID=36141774

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006321A ECSP066321A (es) 2003-07-02 2006-01-26 Análogos de 4-(metilsulfonilamino) fenilo como antagonistas vanilloides que muestran excelente actividad analgésica y composiciones farmacéuticas que comprenden los mismos

Country Status (16)

Country Link
US (1) US8642657B2 (es)
EP (1) EP1658265A4 (es)
JP (1) JP4850702B2 (es)
KR (1) KR100707123B1 (es)
CN (1) CN100537528C (es)
AU (1) AU2004253808B2 (es)
BR (1) BRPI0412229A (es)
CA (1) CA2533547C (es)
EC (1) ECSP066321A (es)
IL (1) IL172671A (es)
IS (1) IS8216A (es)
NO (1) NO332602B1 (es)
NZ (1) NZ544943A (es)
RU (1) RU2362768C2 (es)
WO (1) WO2005003084A1 (es)
ZA (1) ZA200600895B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101087771A (zh) 2004-11-10 2007-12-12 辉瑞大药厂 经取代n－磺酰基氨基苄基－2－苯氧基乙酰胺化合物
WO2006051378A1 (en) * 2004-11-10 2006-05-18 Pfizer Japan Inc. Substituted n-sulfonylaminobenzyl-2-phenoxy acetamide compounds
CA2600409C (en) * 2005-03-10 2011-07-05 Pfizer Inc. Substituted n-sulfonylaminophenylethyl-2-phenoxy acetamide compounds
WO2006098554A1 (en) * 2005-03-16 2006-09-21 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
AP2007004157A0 (en) * 2005-03-17 2007-10-31 Pfizer N- (N-sulfonylaminomethyl) cyclo-propanecarboxamide derivatives useful for the treatment of pain
EP1861357B1 (en) * 2005-03-19 2013-04-24 Amorepacific Corporation Novel compounds or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
DE102005023943A1 (de) 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln
DE102005050408A1 (de) * 2005-10-19 2007-04-26 Grünenthal GmbH Neue Vanilloidrezeptor-Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
PE20110285A1 (es) 2005-10-19 2011-06-04 Gruenenthal Chemie Derivados de sulfonamidofenil propionamida como ligandos del receptor vaniloide del subtipo 1
JP2009536657A (ja) * 2006-05-10 2009-10-15 レノビス， インコーポレイテッド イオンチャンネルリガンドとしてのアミド誘導体およびそれを用いる医薬組成物および方法
PL2024329T3 (pl) * 2006-05-18 2014-03-31 Dompe Farm Spa (2r)-2-[(4-sulfonylo)aminofenylo]propanoamidy i zawierające je kompozycje farmaceutyczne
EP1862454A1 (en) * 2006-06-02 2007-12-05 Amorepacific Corporation Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same
JP2009542798A (ja) * 2006-07-11 2009-12-03 ファイザー株式会社 置換ｎ−二環式アルキル二環式カルボキシアミド化合物
CA2658925C (en) 2006-07-27 2015-07-14 Amorepacific Corporation Novel sulfonylamino acrylamide derivatives, isomer thereof,or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
DE602007008742D1 (de) 2006-09-15 2010-10-07 Pfizer Substituierte pyridylmethylbicyclocarboxyamidverbindungen
DE102007018150A1 (de) * 2007-04-16 2008-10-23 Grünenthal GmbH VR1-Rezeptor-Liganden und µ-Opioid-Rezeptor-Liganden zur Behandlung von Schmerz
EP2222631B1 (en) 2006-10-23 2011-08-17 Pfizer Inc. Substituted phenylmethyl bicyclocarboxyamide compounds
CA2669915C (en) 2006-11-17 2012-02-07 Pfizer Inc. Substituted bicyclocarboxyamide compounds
US20080212725A1 (en) * 2007-02-20 2008-09-04 Haiyun Tang Digital Predistortion for Cognitive Radio
WO2008121859A1 (en) * 2007-03-30 2008-10-09 Xenon Pharmaceuticals Inc. Methods of using tricyclic compounds in treating sodium channel-mediated diseases or conditions
US8735426B2 (en) 2007-04-13 2014-05-27 Gruenenthal Gmbh Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them and use thereof for treating pain and other conditions
DE102007017884A1 (de) 2007-04-13 2008-10-16 Grünethal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
DE102007018149A1 (de) 2007-04-16 2008-10-23 Grünenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
DE102007018151A1 (de) 2007-04-16 2008-10-23 Günenthal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
EP1992228A1 (en) * 2007-05-14 2008-11-19 Bayer CropScience AG Insecticidal substituted thiourea derivatives
US8340924B2 (en) * 2007-10-25 2012-12-25 Toray Industries, Inc. Membranous filtration prediction method, prediction apparatus, and membranous filtration prediction program
US8153651B2 (en) * 2007-11-13 2012-04-10 Evotec Ag Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
JP5643112B2 (ja) * 2008-01-28 2014-12-17 アモーレパシフィック コーポレイションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ バニロイド受容体としての新規化合物、その異性体または薬剤学的に許容し得る塩、及びこれを含有する医薬組成物
JP5438103B2 (ja) * 2008-07-02 2014-03-12 アモーレパシフィック コーポレイション バニロイド受容体アンタゴニストとしての新規化合物、その異性体またはその薬学的に許容される塩、並びにそれを含む医薬組成物
JP5937353B2 (ja) * 2008-08-19 2016-06-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ 冷感−メントール受容体拮抗剤
WO2010056044A2 (ko) * 2008-11-11 2010-05-20 (주)아모레퍼시픽 바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염 및 이를 포함하는 약학 조성물
KR101367057B1 (ko) 2009-03-17 2014-02-25 (주)아모레퍼시픽 피부 자극 완화용 조성물
EP2316820A1 (en) * 2009-10-28 2011-05-04 Dompe S.p.A. 2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them
CN105820069A (zh) * 2015-01-05 2016-08-03 齐鲁工业大学 一种n-{4-[3-（3-溴-苯基）-脲基甲基]-2,5-二丁氧基-苯基}-甲磺酰胺新化合物、制备方法及用途
CN105820076A (zh) * 2015-01-05 2016-08-03 齐鲁工业大学 一种n-[2,5-二乙氧基-4-（3-对-甲苯基-脲基甲基）-苯基]-甲磺酰胺新化合物、制备方法及用途
CN105820073A (zh) * 2015-01-05 2016-08-03 齐鲁工业大学 一种n-{[2,5-二乙氧基-4-[3-（3-甲氧基-苯基）-脲基甲基]-苯基}-甲磺酰胺新化合物、制备方法及用途
CN105820087A (zh) * 2015-01-05 2016-08-03 齐鲁工业大学 一种5-[3-（2,5-二乙氧基-4-甲磺酰基-苄基）-脲基]-2-乙氧基-n-对甲苯基-苯甲酰胺新化合物、制备方法及用途
CN105820088A (zh) * 2015-01-05 2016-08-03 齐鲁工业大学 一种n-（4-溴-苯基）-5-[3-（2,5-二乙氧基-4-甲磺酰基-苄基）-脲基]-2-乙氧基苯甲酰胺新化合物、制备方法及用途
CN106344552B (zh) * 2015-07-15 2021-04-30 齐鲁工业大学 新型磺酰胺类化合物、制备方法及其作为蛋白酪氨酸磷酸酯酶1b抑制剂的用途
IL291783A (en) * 2019-10-02 2022-06-01 Domain Therapeutics ep4 prostaglandin e2 receptor antagonists
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2076098C1 (ru) * 1990-02-07 1997-03-27 Ниппон синяку компани лимитед 3'-(2-амино-1-гидроксиэтил)-4'-фторметансульфонанилид и средство для лечения недержания мочи
WO2000050387A1 (en) * 1999-02-22 2000-08-31 Pacific Corporation Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
JP2004506714A (ja) * 2000-08-21 2004-03-04 パシフィック　コーポレーション 新規チオ尿素化合物及びこれを含有する薬学的組成物
KR100564902B1 (ko) * 2000-08-21 2006-03-30 주식회사 태평양 신규 티오우레아 유도체 및 이를 함유하는 약제학적 조성물
GB0110901D0 (en) * 2001-05-02 2001-06-27 Smithkline Beecham Plc Novel Compounds

Also Published As

Publication number Publication date
KR100707123B1 (ko) 2007-04-16
CA2533547A1 (en) 2005-01-13
RU2362768C2 (ru) 2009-07-27
KR20050004006A (ko) 2005-01-12
CN1852891A (zh) 2006-10-25
BRPI0412229A (pt) 2006-08-22
CN100537528C (zh) 2009-09-09
US20060258884A1 (en) 2006-11-16
WO2005003084A1 (en) 2005-01-13
NZ544943A (en) 2009-07-31
EP1658265A4 (en) 2006-11-29
AU2004253808A1 (en) 2005-01-13
EP1658265A1 (en) 2006-05-24
JP2007521288A (ja) 2007-08-02
RU2006102868A (ru) 2007-08-10
AU2004253808B2 (en) 2011-02-03
IL172671A (en) 2013-08-29
CA2533547C (en) 2013-09-10
IL172671A0 (en) 2006-04-10
US8642657B2 (en) 2014-02-04
ZA200600895B (en) 2009-07-29
NO20060122L (no) 2006-01-09
IS8216A (is) 2005-12-30
NO332602B1 (no) 2012-11-12
JP4850702B2 (ja) 2012-01-11

Similar Documents

Publication Publication Date Title
ECSP066321A (es) Análogos de 4-(metilsulfonilamino) fenilo como antagonistas vanilloides que muestran excelente actividad analgésica y composiciones farmacéuticas que comprenden los mismos
EP1311478A4 (en) NEW THIO-URBAN COMPOUNDS AND MEDICINAL COMPOSITIONS THAT CONTAIN THEM
AU8022901A (en) Novel thiourea derivatives and the pharmaceutical compositions containing the same
PA8622001A1 (es) Derivados de sulfonamida para el tratamiento de enfermedades
MY157033A (en) Novel biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same
CR8649A (es) Derivados de formamidina para el tratamiento de enfermedades
EA200702020A1 (ru) Новые соединения, их изомеры или фармацевтически приемлемые соли в качестве антагонистов ваниллоидных рецепторов и содержащие их фармацевтические композиции
AR069490A1 (es) Agonistas de los receptores de glucocorticoides
DOP2005000004A (es) "derivados sulfonamida para el tratamiento de enfermedades"
WO2009096701A3 (en) Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
PA8603001A1 (es) Compuestos utiles para el tratamiento de enfermedades
PA8627001A1 (es) Compuestos para el tratamiento de enfermedades
CU20090083A7 (es) Análogos de pirazol
WO2010002209A3 (en) Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same
UY40043A (es) Composiciones farmacéuticas y métodos de tratamiento de compuestos cannabinoides sintéticos
SV2005002056A (es) Derivados de formamida para el tratamiento de enfermedades ref. pc32168a
GT200500056A (es) Compuestos utiles para el tratamiento de enfermedades
PA8627101A1 (es) Compuestos para el tratamiento de enfermedades
CR8513A (es) Derivados de sulfonamida para el tratamiento de enfermedades
CU23661B7 (es) Derivados de formamida para el tratamiento de enfermedades
CU23532B7 (es) Derivados de sulfonamida para el tratamiento de enfermedades
CU23537B7 (es) Derivados de sulfonamida para el tratamiento de enfermedades
UY30825A1 (es) Ureas n-[3-[4-(4-cianofenil)piperidina-1-carbonil]fenil]-n'-(alquilo sustituido)sustituidas, procedimiento para la preparacion y aplicaciones
CR9838A (es) Derivados de sulfonamida para el tratamiento de enfermedades
ECSP066854A (es) Compuestos utiles para el tratamiento de enfermedades