ECSP066459A - Miméticos de glucocorticoides, métodos de preparación, composiciones farmacéuticas y usos de los mismos - Google Patents

Miméticos de glucocorticoides, métodos de preparación, composiciones farmacéuticas y usos de los mismos

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Publication number
ECSP066459A
ECSP066459A EC2006006459A ECSP066459A ECSP066459A EC SP066459 A ECSP066459 A EC SP066459A EC 2006006459 A EC2006006459 A EC 2006006459A EC SP066459 A ECSP066459 A EC SP066459A EC SP066459 A ECSP066459 A EC SP066459A
Authority
EC
Ecuador
Prior art keywords
pharmaceutical compositions
glucocorticoids
mimetics
same
preparation methods
Prior art date
Application number
EC2006006459A
Other languages
English (en)
Inventor
Younes Bekkali
Michael J Emmanuel
Abdelhakim Hammack
Christian H J J Harcken
Thomas Martin Kirrane
Daniel Kuzmich
Thomas Wai-Ho Lee
Pingrong Liu
Usha R Patel
Hossein Razavi
Doris Riether
Hidenori Takashi
David S Thomson
Ji Wanj
Renee Zindell
John Robert Proudfoot
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of ECSP066459A publication Critical patent/ECSP066459A/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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Abstract

Compuestos de Fórmulas (IA), (IB), (IC), y (ID) (IA) (IB) (IC) (ID)en las cuales R1, R2, R3, R4, R5 y R6 son como se definen respectivamente en la presente para las Fórmulas (IA), (IB), (IC) y (ID), o un tautómero, profármaco, solvato o una sal de los mismos; composiciones farmacéuticas que contienen tales compuestos, y métodos para modular la función del receptor de glucocorticoides y métodos para tratar un estado o un cuadro patológico mediado por la función del receptor de glucocorticoides o caracterizado por procesos inflamatorios, alérgicos o proliferativos en un paciente que utiliza estos compuestos.
EC2006006459A 2003-09-24 2006-03-24 Miméticos de glucocorticoides, métodos de preparación, composiciones farmacéuticas y usos de los mismos ECSP066459A (es)

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