ECSP066605A - Derivados oxazol de tetraciclina - Google Patents

Derivados oxazol de tetraciclina

Info

Publication number
ECSP066605A
ECSP066605A EC2006006605A ECSP066605A ECSP066605A EC SP066605 A ECSP066605 A EC SP066605A EC 2006006605 A EC2006006605 A EC 2006006605A EC SP066605 A ECSP066605 A EC SP066605A EC SP066605 A ECSP066605 A EC SP066605A
Authority
EC
Ecuador
Prior art keywords
tetracicline
oxazol
derivatives
compounds
useful
Prior art date
Application number
EC2006006605A
Other languages
English (en)
Inventor
Phaik-Eng Sum
David Brian How
Darrin William Hopper
Matthew Douglas Vera
Joshua James Sabatini
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34681543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP066605(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP066605A publication Critical patent/ECSP066605A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Esta invención suministra compuestos de la fórmula I:en donde A", X y Y son según se definió en la especificación. Estos compuestos son útiles como agentes antibacterianos.
EC2006006605A 2003-12-08 2006-06-05 Derivados oxazol de tetraciclina ECSP066605A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52792803P 2003-12-08 2003-12-08
US58482304P 2004-07-01 2004-07-01

Publications (1)

Publication Number Publication Date
ECSP066605A true ECSP066605A (es) 2006-10-25

Family

ID=34681543

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006605A ECSP066605A (es) 2003-12-08 2006-06-05 Derivados oxazol de tetraciclina

Country Status (25)

Country Link
US (3) US7176225B2 (es)
EP (2) EP1692117B1 (es)
JP (1) JP4848287B2 (es)
KR (1) KR101164262B1 (es)
CN (1) CN100545151C (es)
AR (1) AR047274A1 (es)
AT (2) ATE444290T1 (es)
AU (1) AU2004297243B2 (es)
BR (1) BRPI0417421A (es)
CA (1) CA2546895A1 (es)
CO (1) CO5700818A2 (es)
CR (1) CR8437A (es)
DE (1) DE602004023417D1 (es)
EC (1) ECSP066605A (es)
ES (2) ES2331574T3 (es)
IL (2) IL176162A (es)
MY (1) MY146098A (es)
NO (1) NO20062629L (es)
PA (1) PA8619601A1 (es)
PE (1) PE20050995A1 (es)
RU (1) RU2415844C2 (es)
SG (1) SG148216A1 (es)
TW (1) TW200528437A (es)
UA (2) UA83266C2 (es)
WO (1) WO2005056538A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1753713B1 (en) 2004-05-21 2016-07-27 President and Fellows of Harvard College Synthesis of tetracyclines and analogues thereof
EP2301916A3 (en) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
EP2016044B1 (en) 2006-04-07 2020-06-10 President and Fellows of Harvard College Pentacycline derivatives for the treatment of infections
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP2479169B1 (en) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
US8121767B2 (en) * 2007-11-02 2012-02-21 GM Global Technology Operations LLC Predicted and immediate output torque control architecture for a hybrid powertrain system
WO2009062963A1 (en) * 2007-11-14 2009-05-22 Sandoz Ag Crystalline forms of tigecycline hydrochloride
EP2307027A4 (en) 2008-07-11 2012-08-15 Neumedics TETRACYCLINE DERIVATIVES WITH REDUCED ANTIBIOTIC ACTIVITY AND NEUROPROTECTIVE PROPERTIES
CA2746585C (en) 2008-12-18 2017-08-29 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
EP2424834B1 (en) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthesis of tetracyclines and intermediates thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26253A (en) * 1859-11-29 Vegetable-cutter
US2482055A (en) 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
US3007965A (en) 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (es) 1960-05-23 1966-05-25
US3338963A (en) 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3148212A (en) 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3360557A (en) 1963-05-10 1967-12-26 American Cyanamid Co 9-hydroxytetracyclines and a process of preparing same
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3341585A (en) 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3360561A (en) 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US4806529A (en) 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
ES2168254T3 (es) * 1991-10-04 2002-06-16 American Cyanamid Co Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas.
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
PL353360A1 (en) * 1999-08-10 2003-11-17 Smithkline Beecham Corporation 1,4-substituted 4,4-diaryl cyclohexanes
EP2332547A1 (en) * 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of inflammatory bowel disease

Also Published As

Publication number Publication date
CO5700818A2 (es) 2006-11-30
US20080064667A1 (en) 2008-03-13
SG148216A1 (en) 2008-12-31
UA83268C2 (en) 2008-06-25
IL206050A0 (en) 2010-11-30
KR20060105047A (ko) 2006-10-09
ATE444290T1 (de) 2009-10-15
US7365087B2 (en) 2008-04-29
WO2005056538A1 (en) 2005-06-23
CN100545151C (zh) 2009-09-30
RU2415844C2 (ru) 2011-04-10
KR101164262B1 (ko) 2012-07-09
US20050153944A1 (en) 2005-07-14
CR8437A (es) 2006-10-06
CN1890226A (zh) 2007-01-03
EP2157085A1 (en) 2010-02-24
PA8619601A1 (es) 2006-03-24
IL206050A (en) 2013-01-31
CA2546895A1 (en) 2005-06-23
DE602004023417D1 (de) 2009-11-12
JP2007515411A (ja) 2007-06-14
AR047274A1 (es) 2006-01-11
ES2372635T3 (es) 2012-01-25
RU2006118367A (ru) 2008-01-20
UA83266C2 (en) 2008-06-25
EP1692117A1 (en) 2006-08-23
EP2157085B1 (en) 2011-09-21
ATE525365T1 (de) 2011-10-15
AU2004297243B2 (en) 2011-02-17
IL176162A (en) 2011-09-27
PE20050995A1 (es) 2006-01-11
IL176162A0 (en) 2006-10-05
ES2331574T3 (es) 2010-01-08
JP4848287B2 (ja) 2011-12-28
BRPI0417421A (pt) 2007-03-13
TW200528437A (en) 2005-09-01
US20080177080A1 (en) 2008-07-24
EP1692117B1 (en) 2009-09-30
NO20062629L (no) 2006-09-06
MY146098A (en) 2012-06-29
US7176225B2 (en) 2007-02-13
AU2004297243A1 (en) 2005-06-23

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