ECSP066606A - Proceso para la preparación de inhibidores de tubulina - Google Patents

Proceso para la preparación de inhibidores de tubulina

Info

Publication number
ECSP066606A
ECSP066606A EC2006006606A ECSP066606A ECSP066606A EC SP066606 A ECSP066606 A EC SP066606A EC 2006006606 A EC2006006606 A EC 2006006606A EC SP066606 A ECSP066606 A EC SP066606A EC SP066606 A ECSP066606 A EC SP066606A
Authority
EC
Ecuador
Prior art keywords
alkyl
preparation
atoms
tubulin inhibitors
substituted
Prior art date
Application number
EC2006006606A
Other languages
English (en)
Inventor
Yanzhong Wu
David Michael Blum
Semiramis Ayral-Kaloustian
Jean Schmid
Jay Thomas Afragola
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP066606A publication Critical patent/ECSP066606A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención suministra un proceso para la preparación de sal de ácido 6-[fenilo(sustituido)]-tiazolopirimidina dicarboxílico y como sal hidratada que tiene la formula estructural (I),En donde:R1 es CF3 o C2F5;R2 es H o alquilo C1-C3;n es un entero de 2, 3 o 4;X es Cl;R3 y R4 son cada uno independientemente H o alquilo C1-C3; oR3 y R4 cuando se toman opcionalmente juntos con el átomo de nitrógeno al cual cada uno esta unido forman un anillo de heterocíclicos saturado de 4 a 6 miembros que tiene 1-2 átomos de nitrógeno y 0-1 átomos de oxigeno o 0-2 átomos de azufre y opcionalmente sustituido con R5;R5 es alquilo C1-C3;En donde la línea punteada es un enlace opcional.
EC2006006606A 2003-12-08 2006-06-05 Proceso para la preparación de inhibidores de tubulina ECSP066606A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52793103P 2003-12-08 2003-12-08

Publications (1)

Publication Number Publication Date
ECSP066606A true ECSP066606A (es) 2006-10-25

Family

ID=34676796

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006606A ECSP066606A (es) 2003-12-08 2006-06-05 Proceso para la preparación de inhibidores de tubulina

Country Status (28)

Country Link
US (1) US7396835B2 (es)
EP (1) EP1692137B1 (es)
JP (1) JP2007513185A (es)
KR (1) KR20060094984A (es)
CN (1) CN1890245A (es)
AR (1) AR046939A1 (es)
AT (1) ATE356128T1 (es)
AU (1) AU2004297244A1 (es)
BR (1) BRPI0417422A (es)
CA (1) CA2546899A1 (es)
CO (1) CO5700827A2 (es)
CR (1) CR8435A (es)
DE (1) DE602004005239T2 (es)
DK (1) DK1692137T3 (es)
EC (1) ECSP066606A (es)
ES (1) ES2281850T3 (es)
GT (1) GT200400248A (es)
IL (1) IL175775A0 (es)
MY (1) MY179926A (es)
NO (1) NO20062492L (es)
NZ (1) NZ547471A (es)
PA (1) PA8619401A1 (es)
PE (1) PE20050593A1 (es)
PL (1) PL1692137T3 (es)
RU (1) RU2006117023A (es)
TW (1) TW200522963A (es)
WO (1) WO2005056560A1 (es)
ZA (1) ZA200604680B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
TW200808730A (en) * 2006-06-09 2008-02-16 Wyeth Corp Process for synthesizing piperazine-piperidine compounds
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
US9649317B2 (en) 2012-09-19 2017-05-16 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules
CN116178375B (zh) * 2023-02-24 2024-09-20 重庆文理学院 一种三唑并嘧啶化合物及其合成方法和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593996A (en) 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (es) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
EP0984919B1 (en) 1997-03-18 2003-01-22 Basf Aktiengesellschaft Process for the preparation of arylmalonates
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US5986153A (en) 1997-09-30 1999-11-16 Phillips Petroleum Company Olefin color stabilization
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
DE69926119T2 (de) * 1998-03-23 2005-12-29 Basf Ag Fungizide 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidine
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
GEP20053688B (en) 2000-06-30 2005-12-12 Wyeth Corp Substituted-Triazolopyrimidines as Anticancer Agents
ES2279452T3 (es) * 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.
CN101193884A (zh) * 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法

Also Published As

Publication number Publication date
BRPI0417422A (pt) 2007-03-13
ZA200604680B (en) 2009-04-29
PE20050593A1 (es) 2005-09-27
CN1890245A (zh) 2007-01-03
CR8435A (es) 2007-06-08
CA2546899A1 (en) 2005-06-23
ES2281850T3 (es) 2007-10-01
HK1090377A1 (en) 2006-12-22
KR20060094984A (ko) 2006-08-30
DE602004005239T2 (de) 2007-12-20
NO20062492L (no) 2006-07-03
GT200400248A (es) 2005-09-14
RU2006117023A (ru) 2008-01-20
EP1692137A1 (en) 2006-08-23
WO2005056560A1 (en) 2005-06-23
MY179926A (en) 2020-11-19
EP1692137B1 (en) 2007-03-07
AU2004297244A1 (en) 2005-06-23
AR046939A1 (es) 2006-01-04
DK1692137T3 (da) 2007-04-30
NZ547471A (en) 2009-03-31
ATE356128T1 (de) 2007-03-15
IL175775A0 (en) 2006-09-05
TW200522963A (en) 2005-07-16
PA8619401A1 (es) 2005-08-04
JP2007513185A (ja) 2007-05-24
CO5700827A2 (es) 2006-11-30
PL1692137T3 (pl) 2007-06-29
US20050124635A1 (en) 2005-06-09
US7396835B2 (en) 2008-07-08
DE602004005239D1 (de) 2007-04-19

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