ECSP066626A - Nuevos inhibidores de la ns3/ns4a serina proteasa del virus de la hepatitis c - Google Patents

Nuevos inhibidores de la ns3/ns4a serina proteasa del virus de la hepatitis c

Info

Publication number
ECSP066626A
ECSP066626A EC2006006626A ECSP066626A ECSP066626A EC SP066626 A ECSP066626 A EC SP066626A EC 2006006626 A EC2006006626 A EC 2006006626A EC SP066626 A ECSP066626 A EC SP066626A EC SP066626 A ECSP066626 A EC SP066626A
Authority
EC
Ecuador
Prior art keywords
ns4a
hepatitis
virus
new inhibitors
proteasa
Prior art date
Application number
EC2006006626A
Other languages
English (en)
Inventor
F George Njoroge
Srikanth Venkatraman
Francisco Velazquez
Original Assignee
Scherinng Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34699904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP066626(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scherinng Corp filed Critical Scherinng Corp
Publication of ECSP066626A publication Critical patent/ECSP066626A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención revela compuestos novedosos que tienen actividad inhibidora de la proteasa del VHC como así también métodos para preparar tales compuestos. En otra realización, la invención revela composiciones farmacéuticas que comprenden tales compuestos como así también métodos para utilizarlos para tratar trastornos asociados con la proteasa del VHC.
EC2006006626A 2003-12-11 2006-06-08 Nuevos inhibidores de la ns3/ns4a serina proteasa del virus de la hepatitis c ECSP066626A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52884503P 2003-12-11 2003-12-11

Publications (1)

Publication Number Publication Date
ECSP066626A true ECSP066626A (es) 2006-10-25

Family

ID=34699904

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006626A ECSP066626A (es) 2003-12-11 2006-06-08 Nuevos inhibidores de la ns3/ns4a serina proteasa del virus de la hepatitis c

Country Status (18)

Country Link
US (1) US7485625B2 (es)
EP (1) EP1742913A1 (es)
JP (1) JP2007513971A (es)
KR (1) KR20060118532A (es)
CN (1) CN100509784C (es)
AR (1) AR046758A1 (es)
AU (1) AU2004298498B2 (es)
BR (1) BRPI0416902A (es)
CA (1) CA2549167A1 (es)
CO (1) CO5700736A2 (es)
EC (1) ECSP066626A (es)
IL (1) IL176237A0 (es)
NO (1) NO20063205L (es)
PE (1) PE20050940A1 (es)
RU (1) RU2006124594A (es)
TW (1) TW200518746A (es)
WO (1) WO2005058821A1 (es)
ZA (1) ZA200604638B (es)

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US20070237818A1 (en) * 2005-06-02 2007-10-11 Malcolm Bruce A Controlled-release formulation of HCV protease inhibitor and methods using the same
WO2006130666A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Medicaments and methods combining a hcv protease inhibitor and an akr competitor
US7772178B2 (en) * 2005-06-02 2010-08-10 Schering Corporation Pharmaceutical formulations and methods of treatment using the same
EP2614709A1 (en) * 2005-07-18 2013-07-17 Novartis AG Small animal model for HCV replication
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AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
EA200801050A1 (ru) * 2005-10-11 2008-12-30 Интермьюн, Инк. Соединения и способы ингибирования репликации вирусного гепатита с
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Also Published As

Publication number Publication date
KR20060118532A (ko) 2006-11-23
AU2004298498B2 (en) 2008-09-11
BRPI0416902A (pt) 2007-01-16
WO2005058821A1 (en) 2005-06-30
TW200518746A (en) 2005-06-16
PE20050940A1 (es) 2005-11-08
JP2007513971A (ja) 2007-05-31
AR046758A1 (es) 2005-12-21
AU2004298498A1 (en) 2005-06-30
IL176237A0 (en) 2006-10-05
ZA200604638B (en) 2007-04-25
EP1742913A1 (en) 2007-01-17
US7485625B2 (en) 2009-02-03
CN100509784C (zh) 2009-07-08
US20050153900A1 (en) 2005-07-14
CA2549167A1 (en) 2005-06-30
CN1890215A (zh) 2007-01-03
CO5700736A2 (es) 2006-11-30
NO20063205L (no) 2006-09-08
RU2006124594A (ru) 2008-01-27

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