ECSP066773A - Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la síntesis de los mismos - Google Patents

Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la síntesis de los mismos

Info

Publication number
ECSP066773A
ECSP066773A EC2006006773A ECSP066773A ECSP066773A EC SP066773 A ECSP066773 A EC SP066773A EC 2006006773 A EC2006006773 A EC 2006006773A EC SP066773 A ECSP066773 A EC SP066773A EC SP066773 A ECSP066773 A EC SP066773A
Authority
EC
Ecuador
Prior art keywords
inhibitors
thirosine
intermediaries
quinoline
synthesis
Prior art date
Application number
EC2006006773A
Other languages
English (en)
Inventor
Youchu Wang
Chew Warren
Maria Pamichelakis
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP066773A publication Critical patent/ECSP066773A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Métodos de preparación de compuestos de quinolina 4-sustituida como intermediarios en la elaboración de inhibidores de receptores de tirosina quinasas y los compuestos intermediarios utilizados en dichos métodos, donde dicho compuesto quinolina 4-sustituida presenta la siguiente fórmula general (I):y donde las sustituciones en LG'', PG, A, G, R1 y R4 son las que se describieron en la memoria descriptiva.
EC2006006773A 2004-01-16 2006-08-16 Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la síntesis de los mismos ECSP066773A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53732904P 2004-01-16 2004-01-16

Publications (1)

Publication Number Publication Date
ECSP066773A true ECSP066773A (es) 2006-11-16

Family

ID=34807094

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006773A ECSP066773A (es) 2004-01-16 2006-08-16 Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la síntesis de los mismos

Country Status (20)

Country Link
US (2) US7432377B2 (es)
EP (1) EP1711467A2 (es)
KR (1) KR20060123545A (es)
CN (1) CN1930128A (es)
AR (1) AR047424A1 (es)
AU (1) AU2005206541A1 (es)
BR (1) BRPI0520812A2 (es)
CA (1) CA2553729A1 (es)
CR (1) CR8530A (es)
EC (1) ECSP066773A (es)
GT (1) GT200500008A (es)
MY (1) MY136959A (es)
NO (1) NO20063501L (es)
PA (1) PA8621501A1 (es)
PE (1) PE20050896A1 (es)
RU (1) RU2006127414A (es)
SG (1) SG149817A1 (es)
TW (1) TW200526219A (es)
UA (1) UA85698C2 (es)
WO (1) WO2005070890A2 (es)

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EP2704572B1 (en) 2011-05-04 2015-12-30 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
US9364476B2 (en) 2011-10-28 2016-06-14 Celgene Avilomics Research, Inc. Methods of treating a Bruton's Tyrosine Kinase disease or disorder
CA2866852C (en) 2012-03-15 2020-12-29 Celgene Avilomics Research, Inc. Solid forms of an epidermal growth factor receptor kinase inhibitor
BR112014022790B1 (pt) 2012-03-15 2022-04-19 Celgene Car Llc Sais de um inibidor de quinase de receptor de fator do crescimento epidermal, composição farmacêutica e usos do mesmo
WO2013169401A1 (en) 2012-05-05 2013-11-14 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
US9126950B2 (en) 2012-12-21 2015-09-08 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
MX2015009952A (es) 2013-02-08 2015-10-05 Celgene Avilomics Res Inc Inhibidores de cinasas reguladas por señales extracelulares (erk) y sus usos.
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP3179858B1 (en) 2014-08-13 2019-05-15 Celgene Car Llc Forms and compositions of an erk inhibitor
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
EP3188642B1 (en) * 2014-09-01 2018-05-30 Electrolux Appliances Aktiebolag Support assembly
JP6740354B2 (ja) 2015-10-05 2020-08-12 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法
CN105503720B (zh) * 2015-12-31 2018-07-03 重庆威鹏药业有限公司 来那替尼中间体的制备方法
CN107501175A (zh) * 2017-07-25 2017-12-22 广州大学 一种喹啉衍生物的合成方法
CN107501174A (zh) * 2017-07-25 2017-12-22 广州大学 一种喹啉衍生物的合成方法
CN107417612A (zh) * 2017-07-25 2017-12-01 广州大学 一种喹啉衍生物的合成方法
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Also Published As

Publication number Publication date
PA8621501A1 (es) 2005-08-10
AU2005206541A1 (en) 2005-08-04
CN1930128A (zh) 2007-03-14
AR047424A1 (es) 2006-01-18
CA2553729A1 (en) 2005-08-04
WO2005070890A3 (en) 2005-11-03
CR8530A (es) 2008-09-23
MY136959A (en) 2008-12-31
EP1711467A2 (en) 2006-10-18
US20090030197A1 (en) 2009-01-29
WO2005070890A2 (en) 2005-08-04
SG149817A1 (en) 2009-02-27
BRPI0520812A2 (pt) 2009-10-06
US20050159446A1 (en) 2005-07-21
NO20063501L (no) 2006-09-28
UA85698C2 (ru) 2009-02-25
KR20060123545A (ko) 2006-12-01
GT200500008A (es) 2005-08-16
TW200526219A (en) 2005-08-16
RU2006127414A (ru) 2008-02-27
US7432377B2 (en) 2008-10-07
PE20050896A1 (es) 2005-11-14

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