ECSP066897A - Síntesis de pirrol-2-carbonitrilos - Google Patents

Síntesis de pirrol-2-carbonitrilos

Info

Publication number
ECSP066897A
ECSP066897A EC2006006897A ECSP066897A ECSP066897A EC SP066897 A ECSP066897 A EC SP066897A EC 2006006897 A EC2006006897 A EC 2006006897A EC SP066897 A ECSP066897 A EC SP066897A EC SP066897 A ECSP066897 A EC SP066897A
Authority
EC
Ecuador
Prior art keywords
pyrrole
solution phase
carbonitrile
precipitate
contacting
Prior art date
Application number
EC2006006897A
Other languages
English (en)
Inventor
Bogdan Kazimierz Wilk
Arkadiy Rubezhov
Jean Louise Helom
Anthony Scott Pilcher
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP066897A publication Critical patent/ECSP066897A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a procesos para la producción de pirrol-2-carbonitrilos tales como 1-metilpirrol-2-carbonitrilo. Dichos procesos comprenden preferiblemente las etapas de hacer reaccionar un pirrol con isocianato de clorosulfonilo en presencia de un disolvente y poner en contacto el producto resultante con un exceso molar de una amina tal como N,N-dimetilformamida. El producto de esa etapa de puesta en contacto se pone en contacto después con un exceso molar de una base orgánica para producir un precipitado y una fase de solución. El precipitado se separa después a partir de una fase de solución y se aísla el pirrol-2-carbonitrilo correspondiente a partir de la fase de solución resultante.
EC2006006897A 2004-03-30 2006-09-29 Síntesis de pirrol-2-carbonitrilos ECSP066897A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55780704P 2004-03-30 2004-03-30
US11/086,061 US7399870B2 (en) 2004-03-30 2005-03-22 Synthesis of pyrrole-2-carbonitriles

Publications (1)

Publication Number Publication Date
ECSP066897A true ECSP066897A (es) 2006-11-24

Family

ID=34963600

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006897A ECSP066897A (es) 2004-03-30 2006-09-29 Síntesis de pirrol-2-carbonitrilos

Country Status (22)

Country Link
US (1) US7399870B2 (es)
EP (1) EP1730109B1 (es)
JP (2) JP5068642B2 (es)
KR (1) KR20070009654A (es)
AR (1) AR049157A1 (es)
AT (1) ATE402145T1 (es)
AU (1) AU2005230896A1 (es)
BR (1) BRPI0509317B1 (es)
CA (1) CA2560964C (es)
CR (1) CR8641A (es)
DE (1) DE602005008408D1 (es)
DK (1) DK1730109T3 (es)
EC (1) ECSP066897A (es)
ES (1) ES2310817T3 (es)
HN (1) HN2005000134A (es)
IL (1) IL178184A0 (es)
NO (1) NO20064891L (es)
PE (1) PE20060203A1 (es)
PL (1) PL1730109T3 (es)
RU (1) RU2006134013A (es)
TW (1) TW200604166A (es)
WO (1) WO2005097743A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170823A1 (en) * 2007-12-20 2009-07-02 Duramed Pharmaceuticals, Inc. Dosage Regimens and Pharmaceutical Compositions and Packages for Emergency Contraception
JP5754768B2 (ja) * 2011-03-10 2015-07-29 学校法人明治大学 芳香族へテロ環化合物のニトリル化物の製造方法
CN117255785A (zh) * 2021-04-27 2023-12-19 株式会社Lg化学 用于合成黄嘌呤氧化酶抑制剂的中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3506642A1 (de) * 1985-02-26 1986-08-28 A. Nattermann & Cie GmbH, 5000 Köln Neue pyrrolamidine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US5204332A (en) 1988-12-05 1993-04-20 American Cyanamid Company Pyrrole carbonitrile and nitropyrrole insecticidal and acaricidal and molluscicidal agents
KR20000047461A (ko) 1998-12-29 2000-07-25 성재갑 트롬빈 억제제

Also Published As

Publication number Publication date
TW200604166A (en) 2006-02-01
HN2005000134A (es) 2007-03-26
WO2005097743A1 (en) 2005-10-20
EP1730109A1 (en) 2006-12-13
JP2007531748A (ja) 2007-11-08
IL178184A0 (en) 2006-12-31
BRPI0509317A (pt) 2007-09-04
BRPI0509317B1 (pt) 2014-04-29
PE20060203A1 (es) 2006-03-30
EP1730109B1 (en) 2008-07-23
US20050222432A1 (en) 2005-10-06
CA2560964A1 (en) 2005-10-20
ATE402145T1 (de) 2008-08-15
AR049157A1 (es) 2006-07-05
NO20064891L (no) 2006-10-26
JP5068642B2 (ja) 2012-11-07
PL1730109T3 (pl) 2008-10-31
RU2006134013A (ru) 2008-05-10
DK1730109T3 (da) 2008-09-29
DE602005008408D1 (en) 2008-09-04
US7399870B2 (en) 2008-07-15
CR8641A (es) 2007-08-28
JP2012158599A (ja) 2012-08-23
AU2005230896A1 (en) 2005-10-20
ES2310817T3 (es) 2009-01-16
CA2560964C (en) 2012-10-30
KR20070009654A (ko) 2007-01-18

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