ECSP066909A - Ascorbato de bazedoxifeno como modulador del receptor de estrogeno selectivo - Google Patents

Ascorbato de bazedoxifeno como modulador del receptor de estrogeno selectivo

Info

Publication number
ECSP066909A
ECSP066909A EC2006006909A ECSP066909A ECSP066909A EC SP066909 A ECSP066909 A EC SP066909A EC 2006006909 A EC2006006909 A EC 2006006909A EC SP066909 A ECSP066909 A EC SP066909A EC SP066909 A ECSP066909 A EC SP066909A
Authority
EC
Ecuador
Prior art keywords
ascorbate
bazedoxifen
strogen
selective
receiver modulator
Prior art date
Application number
EC2006006909A
Other languages
English (en)
Inventor
Kadum Abdul Nabi Ali
Mahdi Bakir Fawzi
Syed M Shah
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP066909A publication Critical patent/ECSP066909A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención está dirigida a ascorbato de bazedoxifeno, composiciones que contienen el mismo, dispersiones del mismo, preparaciones del mismo y usos del mismo.
EC2006006909A 2004-04-08 2006-10-06 Ascorbato de bazedoxifeno como modulador del receptor de estrogeno selectivo ECSP066909A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56045404P 2004-04-08 2004-04-08

Publications (1)

Publication Number Publication Date
ECSP066909A true ECSP066909A (es) 2006-12-20

Family

ID=34964936

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006909A ECSP066909A (es) 2004-04-08 2006-10-06 Ascorbato de bazedoxifeno como modulador del receptor de estrogeno selectivo

Country Status (16)

Country Link
US (2) US7504394B2 (es)
EP (1) EP1732888A1 (es)
JP (1) JP2007532556A (es)
KR (1) KR20060134146A (es)
CN (1) CN1946689A (es)
AU (1) AU2005233128A1 (es)
BR (1) BRPI0509385A (es)
CA (1) CA2561004A1 (es)
CR (1) CR8616A (es)
EC (1) ECSP066909A (es)
IL (1) IL177957A0 (es)
MX (1) MXPA06011686A (es)
NO (1) NO20065054L (es)
RU (1) RU2006132181A (es)
WO (1) WO2005100315A1 (es)
ZA (1) ZA200608362B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2006132181A (ru) * 2004-04-08 2008-05-20 Вайет (Us) Базедоксифен аскорбат в качестве селективного модулятора рецептора эстрогена
WO2007002823A2 (en) * 2005-06-29 2007-01-04 Wyeth Formulations of conjugated estrogens and bazedoxifene
CN101331515B (zh) * 2005-12-21 2013-03-27 日本电气株式会社 色调校正方法、色调校正装置以及图像设备
CZ302358B6 (cs) * 2007-07-25 2011-03-30 Zentiva, A. S. Nové soli bazedoxifenu
WO2009118356A2 (en) * 2008-03-25 2009-10-01 Formac Pharmaceuticals N.V. Preparation method for solid disupersions
WO2012007453A1 (en) * 2010-07-14 2012-01-19 Sandoz Ag Crystalline compound of 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1h-indol-5-ol
WO2012037187A2 (en) * 2010-09-14 2012-03-22 Dr. Reddy's Laboratories Ltd. Preparation of crystalline bazedoxifene and its salts
CN103845336B (zh) * 2014-03-24 2016-03-09 江苏知原药业有限公司 一种性能优异的乙酸巴多昔芬组合物
CN106198827B (zh) * 2016-08-11 2018-03-27 齐鲁制药有限公司 高效测定醋酸巴多昔芬及其杂质的药物分析方法
CN108218760A (zh) * 2018-02-26 2018-06-29 福建省微生物研究所 一种巴多昔芬l-乳酸盐的晶型
IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato
US11246874B1 (en) 2021-04-20 2022-02-15 Oxygen Biotech LLC Treatment of COVID-19

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US5332727A (en) * 1993-04-29 1994-07-26 Birkmayer U.S.A. Stable, ingestable and absorbable NADH and NADPH therapeutic compositions
US5811120A (en) * 1994-03-02 1998-09-22 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
US5478847A (en) * 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
US5552412A (en) 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US5919800A (en) * 1995-02-28 1999-07-06 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US5880137A (en) * 1996-04-19 1999-03-09 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
US5780497A (en) * 1996-04-19 1998-07-14 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
US5998402A (en) * 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
TW397821B (en) 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
ATE206701T1 (de) 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
US6005102A (en) * 1997-10-15 1999-12-21 American Home Products Corporation Aryloxy-alkyl-dialkylamines
ATE355264T1 (de) 1997-10-15 2006-03-15 Wyeth Corp Neue aryloxy-alkyl-dialkylamine
US6479535B1 (en) * 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
AR029538A1 (es) * 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
EP1336602A1 (en) 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
AU2003248707A1 (en) * 2002-06-13 2003-12-31 Wyeth Bazedoxifene treatment regimens
RU2006132181A (ru) * 2004-04-08 2008-05-20 Вайет (Us) Базедоксифен аскорбат в качестве селективного модулятора рецептора эстрогена

Also Published As

Publication number Publication date
CN1946689A (zh) 2007-04-11
AU2005233128A1 (en) 2005-10-27
US20050227964A1 (en) 2005-10-13
CA2561004A1 (en) 2005-10-27
CR8616A (es) 2007-03-22
US20090137559A1 (en) 2009-05-28
NO20065054L (no) 2006-11-07
KR20060134146A (ko) 2006-12-27
JP2007532556A (ja) 2007-11-15
US7504394B2 (en) 2009-03-17
EP1732888A1 (en) 2006-12-20
IL177957A0 (en) 2006-12-31
WO2005100315A1 (en) 2005-10-27
BRPI0509385A (pt) 2007-09-18
MXPA06011686A (es) 2006-12-14
RU2006132181A (ru) 2008-05-20
ZA200608362B (en) 2009-09-30

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