ECSP066997A - Derivados de pirimidina para tratar el crecimiento celular anómalo - Google Patents
Derivados de pirimidina para tratar el crecimiento celular anómaloInfo
- Publication number
- ECSP066997A ECSP066997A EC2006006997A ECSP066997A ECSP066997A EC SP066997 A ECSP066997 A EC SP066997A EC 2006006997 A EC2006006997 A EC 2006006997A EC SP066997 A ECSP066997 A EC SP066997A EC SP066997 A ECSP066997 A EC SP066997A
- Authority
- EC
- Ecuador
- Prior art keywords
- cell growth
- anomal
- treat
- pirimidine derivatives
- derivatives
- Prior art date
Links
- 230000010261 cell growth Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a un compuesto de fórmula I (consta gráfico) en la que R1-R4 son como se definen en esta memoria. Dichos derivados de pirimidina nuevos son útiles en el tratamiento del crecimiento celular anómalo, tal como el cáncer, en mamíferos. Esta invención también se refiere a un método para usar dichos compuestos en el tratamiento del crecimiento celular anómalo en mamíferos, especialmente seres humanos, y a composiciones farmacéuticas que contienen dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57131204P | 2004-05-14 | 2004-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP066997A true ECSP066997A (es) | 2007-02-28 |
Family
ID=34966230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2006006997A ECSP066997A (es) | 2004-05-14 | 2006-11-13 | Derivados de pirimidina para tratar el crecimiento celular anómalo |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1751143A1 (es) |
| JP (1) | JP4099212B2 (es) |
| KR (1) | KR100886990B1 (es) |
| CN (2) | CN102127058A (es) |
| AP (1) | AP2241A (es) |
| AR (1) | AR049097A1 (es) |
| AU (2) | AU2005243397A1 (es) |
| BR (1) | BRPI0511138A (es) |
| CA (1) | CA2566707A1 (es) |
| CR (1) | CR8749A (es) |
| EA (1) | EA200601796A1 (es) |
| EC (1) | ECSP066997A (es) |
| GE (1) | GEP20104875B (es) |
| GT (1) | GT200500113A (es) |
| IL (1) | IL178828A0 (es) |
| MA (1) | MA28583B1 (es) |
| MX (1) | MXPA06011890A (es) |
| NL (2) | NL1029045C2 (es) |
| NO (1) | NO20064576L (es) |
| NZ (1) | NZ550448A (es) |
| PA (1) | PA8632601A1 (es) |
| PE (1) | PE20060240A1 (es) |
| TN (1) | TNSN06370A1 (es) |
| TW (1) | TWI303635B (es) |
| UY (1) | UY28894A1 (es) |
| WO (1) | WO2005111023A1 (es) |
| ZA (1) | ZA200608394B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4812763B2 (ja) * | 2004-05-18 | 2011-11-09 | ライジェル ファーマシューティカルズ， インコーポレイテッド | シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途 |
| US20070032514A1 (en) * | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| WO2007072158A2 (en) * | 2005-12-21 | 2007-06-28 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| DK2146779T3 (en) * | 2007-04-18 | 2016-11-28 | Pfizer Prod Inc | Sulfonylamid derivatives to treat abnormal cell growth. |
| AU2008275918B2 (en) * | 2007-07-17 | 2014-01-30 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as PKC inhibitors |
| WO2009071535A1 (en) * | 2007-12-03 | 2009-06-11 | Boehringer Ingelheim International Gmbh | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
| MX2010012703A (es) * | 2008-05-21 | 2010-12-21 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
| US8410126B2 (en) * | 2009-05-29 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pyrimidine inhibitors of PKTK2 |
| EP2464633A1 (en) | 2009-08-14 | 2012-06-20 | Boehringer Ingelheim International GmbH | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| WO2014174745A1 (ja) * | 2013-04-26 | 2014-10-30 | 国立大学法人京都大学 | Ｅｇ５阻害剤 |
| CN109608444B (zh) * | 2018-11-27 | 2022-02-11 | 中国药科大学 | 含异吲哚啉酮的erk抑制剂及其制备方法与用途 |
| CN111732548B (zh) * | 2020-06-11 | 2022-06-17 | 浙江大学 | N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途 |
| WO2024140671A1 (zh) * | 2022-12-29 | 2024-07-04 | 南京昕瑞再生医药科技有限公司 | 一种稠三环类衍生物、包含其的药物组合物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| CA2529611C (en) * | 2002-12-20 | 2009-12-15 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
-
2005
- 2005-05-02 WO PCT/IB2005/001201 patent/WO2005111023A1/en not_active Ceased
- 2005-05-02 NZ NZ550448A patent/NZ550448A/en not_active IP Right Cessation
- 2005-05-02 EA EA200601796A patent/EA200601796A1/ru unknown
- 2005-05-02 CN CN2011100212904A patent/CN102127058A/zh active Pending
- 2005-05-02 KR KR1020067023767A patent/KR100886990B1/ko not_active Expired - Lifetime
- 2005-05-02 EP EP05732043A patent/EP1751143A1/en not_active Withdrawn
- 2005-05-02 CN CNA2005800155302A patent/CN1953974A/zh active Pending
- 2005-05-02 BR BRPI0511138-2A patent/BRPI0511138A/pt not_active IP Right Cessation
- 2005-05-02 AP AP2006003790A patent/AP2241A/xx active
- 2005-05-02 CA CA002566707A patent/CA2566707A1/en not_active Abandoned
- 2005-05-02 MX MXPA06011890A patent/MXPA06011890A/es unknown
- 2005-05-02 GE GEAP20059703A patent/GEP20104875B/en unknown
- 2005-05-02 JP JP2007512557A patent/JP4099212B2/ja not_active Expired - Lifetime
- 2005-05-02 AU AU2005243397A patent/AU2005243397A1/en not_active Abandoned
- 2005-05-11 TW TW094115237A patent/TWI303635B/zh not_active IP Right Cessation
- 2005-05-11 PA PA20058632601A patent/PA8632601A1/es unknown
- 2005-05-12 UY UY28894A patent/UY28894A1/es not_active Application Discontinuation
- 2005-05-12 PE PE2005000534A patent/PE20060240A1/es not_active Application Discontinuation
- 2005-05-13 GT GT200500113A patent/GT200500113A/es unknown
- 2005-05-13 NL NL1029045A patent/NL1029045C2/nl not_active IP Right Cessation
- 2005-05-13 AR ARP050101969A patent/AR049097A1/es not_active Application Discontinuation
-
2006
- 2006-05-19 NL NL1031845A patent/NL1031845C2/nl not_active IP Right Cessation
- 2006-10-06 ZA ZA200608394A patent/ZA200608394B/xx unknown
- 2006-10-09 NO NO20064576A patent/NO20064576L/no not_active Application Discontinuation
- 2006-10-23 IL IL178828A patent/IL178828A0/en unknown
- 2006-11-13 CR CR8749A patent/CR8749A/es not_active Application Discontinuation
- 2006-11-13 EC EC2006006997A patent/ECSP066997A/es unknown
- 2006-11-13 TN TNP2006000370A patent/TNSN06370A1/fr unknown
- 2006-11-14 MA MA29452A patent/MA28583B1/fr unknown
-
2009
- 2009-11-13 AU AU2009238255A patent/AU2009238255A1/en not_active Ceased
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