ECSP067108A - INHIBITOR OF 11-BETA-HYDROXI STEROID DEHYDROGENASE TYPE 1 - Google Patents

INHIBITOR OF 11-BETA-HYDROXI STEROID DEHYDROGENASE TYPE 1

Info

Publication number
ECSP067108A
ECSP067108A EC2006007108A ECSP067108A ECSP067108A EC SP067108 A ECSP067108 A EC SP067108A EC 2006007108 A EC2006007108 A EC 2006007108A EC SP067108 A ECSP067108 A EC SP067108A EC SP067108 A ECSP067108 A EC SP067108A
Authority
EC
Ecuador
Prior art keywords
hydroxi
beta
inhibitor
dehydrogenase type
steroid dehydrogenase
Prior art date
Application number
EC2006007108A
Other languages
Spanish (es)
Inventor
Martin Henriksson
Evert Homan
Lars Johansson
Jerk Vallgarda
Meredith Williams
Eric Bercot
Christopher H Fotsch
Aiwen Li
Guolin Cai
Randall W Hungate
Chester Chenguang Yuan
Christopher Tegley
Jean David St
Inane Han
Qi Huang
Qingyian Liu
Michael D Bartberger
George A Moniz
Matthew J Frizzle
Original Assignee
Amgen Inc
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0401324A external-priority patent/SE0401324D0/en
Priority claimed from SE0402509A external-priority patent/SE0402509D0/en
Application filed by Amgen Inc, Biovitrum Ab filed Critical Amgen Inc
Publication of ECSP067108A publication Critical patent/ECSP067108A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a compuestos con la formula (I), (II), (III) o (IV): (I) (II), (III), o (IV),en los cuales R1, R2, R3, R4, R5, R6, R7, X y Z son como se define aquí,y además a composiciones farmacéuticas que comprenden los compuestos, como también métodos de uso de los compuestos para el tratamiento de trastornos asociados con la enzima deshidrogenasa 11-ß-hidroxiesteroide tipo 1 y para la preparación de un medicamento que actúa sobre la enzima deshidrogenasa 11-ß-hidroxiesteroide tipo 1 humana.The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), in which R1, R2, R3 , R4, R5, R6, R7, X and Z are as defined herein, and in addition to pharmaceutical compositions comprising the compounds, as well as methods of using the compounds for the treatment of disorders associated with the enzyme dehydrogenase 11-β- type 1 hydroxysteroid and for the preparation of a medicament that acts on the human 11-β-hydroxysteroid dehydrogenase enzyme type 1.

EC2006007108A 2004-05-24 2006-12-21 INHIBITOR OF 11-BETA-HYDROXI STEROID DEHYDROGENASE TYPE 1 ECSP067108A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0401324A SE0401324D0 (en) 2004-05-24 2004-05-24 New compounds
SE0402509A SE0402509D0 (en) 2004-10-15 2004-10-15 New compounds
US65077705P 2005-01-31 2005-01-31

Publications (1)

Publication Number Publication Date
ECSP067108A true ECSP067108A (en) 2007-05-30

Family

ID=41717469

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006007108A ECSP067108A (en) 2004-05-24 2006-12-21 INHIBITOR OF 11-BETA-HYDROXI STEROID DEHYDROGENASE TYPE 1

Country Status (9)

Country Link
KR (1) KR101296408B1 (en)
CR (2) CR8771A (en)
EC (1) ECSP067108A (en)
HR (1) HRP20060456A2 (en)
IL (1) IL179167A (en)
MA (1) MA28662B1 (en)
MX (1) MXPA06013657A (en)
NO (1) NO20065781L (en)
NZ (1) NZ552284A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ302691B6 (en) 1998-07-08 2011-09-07 Sanofi - Aventis Deutschland GmbH N-arylamide compound, process for its preparation, pharmaceutical composition containing thereof, the compound for use as activator and for use in therapy or prophylaxis

Also Published As

Publication number Publication date
HK1096095A1 (en) 2007-05-25
NZ552284A (en) 2010-01-29
CR8771A (en) 2007-07-24
IL179167A0 (en) 2007-03-08
NO20065781L (en) 2007-02-08
KR101296408B1 (en) 2013-08-13
KR20070058382A (en) 2007-06-08
CR20120420A (en) 2012-09-14
MXPA06013657A (en) 2007-11-07
IL179167A (en) 2012-01-31
MA28662B1 (en) 2007-06-01
HRP20060456A2 (en) 2007-03-31

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