ECSP077274A - Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide - Google Patents

Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide

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Publication number
ECSP077274A
ECSP077274A EC2007007274A ECSP077274A ECSP077274A EC SP077274 A ECSP077274 A EC SP077274A EC 2007007274 A EC2007007274 A EC 2007007274A EC SP077274 A ECSP077274 A EC SP077274A EC SP077274 A ECSP077274 A EC SP077274A
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Ecuador
Prior art keywords
alkyl
hydrogen
halo
hydroxy
alkyloxy
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EC2007007274A
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English (en)
Inventor
Joannes Theodorus Maria Linders
Libuse Jaroskova
Der Veken Louis Jozef Elisabeth Van
Gustaaf Henri Maria Willemsens
Francois Paul Bischoff
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP077274A publication Critical patent/ECSP077274A/es

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    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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Abstract

Un compuesto que tiene la fórmula:sus formas de N-óxido, sus sales de adición farmacéuticamente aceptables y sus formas estereoquímicamente isómeras, en donde: n es 1; 2; 3; ó 4; Z representa O, S, NR6, SO o SO2; R1 representa hidrógeno, ciano, hidroxi, o alquilo de C1-4 opcionalmente sustituido con halo; R2 representa hidrógeno, alquilo de C1-4, o alquiloxi de C1-4-; R3 representa hidrógeno, alquilo de C1-4, alquiloxi de C1-4-, o R3 combinado con R2 forman juntos un radical divalente seleccionado del grupo que consiste en -O-CH2- (a), -NR7-CH2- (b), -(CR8R9)m- (c) y -CR10= (d) en donde m representa 1 ó 2, y R7, R8, R9 y R10 se seleccionan, cada uno de manera independiente, de hidrógeno o alquilo de C1-4; R4 representa hidrógeno, halo, hidroxi, ciano, amino, NR11R12, alquiloxi de C1-4- opcionalmente sustituido con uno, o cuando sea posible, dos o tres sustituyentes seleccionados de hidroxi y halo, o R4 representa alquilo de C1-4 opcionalmente sustituido con uno, o cuando sea posible, dos o tres sustituyentes seleccionados de hidroxi y halo; R5 representa hidrógeno, halo, ciano, amino, fenilo, hidroxi, alquiloxicarbonilo de C1-4, hidroxicarbonilo, NR13R14, o alquilo de C1-4 sustituido con uno o más sustituyentes seleccionados de hidroxicarbonilo, fenilo, alquiloxi de C1-4 o NR15R16; R6 representa hidrógeno; R11 y R12 representan, cada uno de manera independiente, hidrógeno, alquilo de C1-4 o alquilcarbonilo de C1-4-; R13 y R14 representan, cada uno de manera independiente, hidrógeno, alquilo de C1-4, o alquilcarbonilo de C1-4-; R15 y R16 representan, cada uno de manera independiente, hidrógeno, alquilo de C1-4, o alquilcarbonilo de C1-4-; R17 y R18 representan, cada uno de manera independiente, hidrógeno, alquilo de C1-4, o alquilcarbonilo de C1-4.
EC2007007274A 2004-08-30 2007-02-26 Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide ECSP077274A (es)

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US (1) US8344181B2 (es)
EP (1) EP1796657B1 (es)
JP (1) JP5208505B2 (es)
KR (1) KR101197674B1 (es)
CN (1) CN101300005B (es)
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AT (1) ATE452631T1 (es)
AU (1) AU2005279208B2 (es)
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CA (1) CA2576839C (es)
CR (1) CR8944A (es)
DE (1) DE602005018509D1 (es)
EA (1) EA012263B1 (es)
EC (1) ECSP077274A (es)
ES (1) ES2338441T3 (es)
IL (1) IL181582A (es)
MX (1) MX2007002449A (es)
MY (1) MY146435A (es)
NO (1) NO20071697L (es)
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TW (1) TWI365067B (es)
UA (1) UA87328C2 (es)
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