ECSP077274A - Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide - Google Patents

Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide

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Publication number
ECSP077274A
ECSP077274A EC2007007274A ECSP077274A ECSP077274A EC SP077274 A ECSP077274 A EC SP077274A EC 2007007274 A EC2007007274 A EC 2007007274A EC SP077274 A ECSP077274 A EC SP077274A EC SP077274 A ECSP077274 A EC SP077274A
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EC
Ecuador
Prior art keywords
alkyl
hydrogen
halo
hydroxy
alkyloxy
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EC2007007274A
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English (en)
Inventor
Joannes Theodorus Maria Linders
Libuse Jaroskova
Der Veken Louis Jozef Elisabeth Van
Gustaaf Henri Maria Willemsens
Francois Paul Bischoff
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP077274A publication Critical patent/ECSP077274A/es

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Abstract

Un compuesto que tiene la fórmula:sus formas de N-óxido, sus sales de adición farmacéuticamente aceptables y sus formas estereoquímicamente isómeras, en donde: n es 1; 2; 3; ó 4; Z representa O, S, NR6, SO o SO2; R1 representa hidrógeno, ciano, hidroxi, o alquilo de C1-4 opcionalmente sustituido con halo; R2 representa hidrógeno, alquilo de C1-4, o alquiloxi de C1-4-; R3 representa hidrógeno, alquilo de C1-4, alquiloxi de C1-4-, o R3 combinado con R2 forman juntos un radical divalente seleccionado del grupo que consiste en -O-CH2- (a), -NR7-CH2- (b), -(CR8R9)m- (c) y -CR10= (d) en donde m representa 1 ó 2, y R7, R8, R9 y R10 se seleccionan, cada uno de manera independiente, de hidrógeno o alquilo de C1-4; R4 representa hidrógeno, halo, hidroxi, ciano, amino, NR11R12, alquiloxi de C1-4- opcionalmente sustituido con uno, o cuando sea posible, dos o tres sustituyentes seleccionados de hidroxi y halo, o R4 representa alquilo de C1-4 opcionalmente sustituido con uno, o cuando sea posible, dos o tres sustituyentes seleccionados de hidroxi y halo; R5 representa hidrógeno, halo, ciano, amino, fenilo, hidroxi, alquiloxicarbonilo de C1-4, hidroxicarbonilo, NR13R14, o alquilo de C1-4 sustituido con uno o más sustituyentes seleccionados de hidroxicarbonilo, fenilo, alquiloxi de C1-4 o NR15R16; R6 representa hidrógeno; R11 y R12 representan, cada uno de manera independiente, hidrógeno, alquilo de C1-4 o alquilcarbonilo de C1-4-; R13 y R14 representan, cada uno de manera independiente, hidrógeno, alquilo de C1-4, o alquilcarbonilo de C1-4-; R15 y R16 representan, cada uno de manera independiente, hidrógeno, alquilo de C1-4, o alquilcarbonilo de C1-4-; R17 y R18 representan, cada uno de manera independiente, hidrógeno, alquilo de C1-4, o alquilcarbonilo de C1-4.
EC2007007274A 2004-08-30 2007-02-26 Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide ECSP077274A (es)

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EP (1) EP1796657B1 (es)
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DE (1) DE602005018509D1 (es)
EA (1) EA012263B1 (es)
EC (1) ECSP077274A (es)
ES (1) ES2338441T3 (es)
IL (1) IL181582A (es)
MX (1) MX2007002449A (es)
MY (1) MY146435A (es)
NO (1) NO20071697L (es)
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UA (1) UA87328C2 (es)
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