ECSP078044A - NON-STEROID PROGESTERONE RECEIVER MODULATORS - Google Patents
NON-STEROID PROGESTERONE RECEIVER MODULATORSInfo
- Publication number
- ECSP078044A ECSP078044A EC2007008044A ECSP078044A ECSP078044A EC SP078044 A ECSP078044 A EC SP078044A EC 2007008044 A EC2007008044 A EC 2007008044A EC SP078044 A ECSP078044 A EC SP078044A EC SP078044 A ECSP078044 A EC SP078044A
- Authority
- EC
- Ecuador
- Prior art keywords
- therapy
- prevention
- receptor modulators
- progesterone receptor
- steroid progesterone
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title 2
- 229960003387 progesterone Drugs 0.000 title 1
- 239000000186 progesterone Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 239000002379 progesterone receptor modulator Substances 0.000 abstract 2
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 208000032843 Hemorrhage Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
- 201000007954 uterine fibroid Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a moduladores no-esteroides de receptor de progesterona de la fórmula general (I), al proceso para su preparación, al uso de los moduladores del receptor de progesterona para la producción de medicamentos así como también composiciones farmacéuticas que contienen estos compuestos. Los compuestos según la invención son apropiados para la terapia y la prevención de enfermedades ginecológicas tales como endometriosis, leiomiomas de útero, hemorragias disfuncionales y dismenorrea y para la terapia y la prevención de tumores dependientes de hormonas y para el uso para el control de la fertilidad femenina y para la terapia de reemplazo hormonal.The present invention relates to non-steroidal progesterone receptor modulators of the general formula (I), to the process for their preparation, to the use of progesterone receptor modulators for the production of medicaments as well as pharmaceutical compositions containing these compounds. The compounds according to the invention are suitable for the therapy and prevention of gynecological diseases such as endometriosis, uterine leiomyomas, dysfunctional hemorrhages and dysmenorrhea and for the therapy and prevention of hormone-dependent tumors and for use for fertility control. female and for hormone replacement therapy.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005030292A DE102005030292A1 (en) | 2005-06-24 | 2005-06-24 | Nonsteroidal progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP078044A true ECSP078044A (en) | 2008-01-23 |
Family
ID=37199176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2007008044A ECSP078044A (en) | 2005-06-24 | 2007-12-21 | NON-STEROID PROGESTERONE RECEIVER MODULATORS |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1902049A2 (en) |
| JP (1) | JP2008543910A (en) |
| KR (1) | KR20080030622A (en) |
| CN (1) | CN101248066A (en) |
| AR (1) | AR054519A1 (en) |
| AU (1) | AU2006261048A1 (en) |
| BR (1) | BRPI0611903A2 (en) |
| CA (1) | CA2611897A1 (en) |
| CR (1) | CR9598A (en) |
| DE (1) | DE102005030292A1 (en) |
| DO (1) | DOP2006000148A (en) |
| EA (1) | EA200702524A1 (en) |
| EC (1) | ECSP078044A (en) |
| GT (1) | GT200600271A (en) |
| IL (1) | IL188021A0 (en) |
| MX (1) | MX2008000072A (en) |
| NO (1) | NO20080440L (en) |
| PE (1) | PE20070125A1 (en) |
| TW (1) | TW200740778A (en) |
| UY (1) | UY29624A1 (en) |
| WO (1) | WO2006136461A2 (en) |
| ZA (1) | ZA200800690B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY30805A1 (en) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS |
| DE102007032800A1 (en) * | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nonsteroidal progesterone receptor modulators |
| DE102007058747A1 (en) * | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nonsteroidal progesterone receptor modulators |
| WO2010002075A1 (en) * | 2008-07-02 | 2010-01-07 | Pharmacostech Co., Ltd. | Methods for preparing amide derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19856475A1 (en) * | 1998-11-27 | 2000-05-31 | Schering Ag | Nonsteroidal anti-inflammatories |
| EP1344776A1 (en) * | 2002-03-11 | 2003-09-17 | Schering Aktiengesellschaft | 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders |
| WO2005003098A1 (en) * | 2003-07-01 | 2005-01-13 | Schering Aktiengesellschaft | Heterocyclically substituted pentanol derivatives, method for the production thereof, and use thereof as anti-inflammatory agents |
-
2005
- 2005-06-24 DE DE102005030292A patent/DE102005030292A1/en not_active Ceased
-
2006
- 2006-06-22 EP EP06762404A patent/EP1902049A2/en not_active Withdrawn
- 2006-06-22 EA EA200702524A patent/EA200702524A1/en unknown
- 2006-06-22 KR KR1020087001793A patent/KR20080030622A/en not_active Withdrawn
- 2006-06-22 AU AU2006261048A patent/AU2006261048A1/en not_active Abandoned
- 2006-06-22 BR BRPI0611903-4A patent/BRPI0611903A2/en not_active Application Discontinuation
- 2006-06-22 CN CNA2006800308707A patent/CN101248066A/en active Pending
- 2006-06-22 WO PCT/EP2006/006531 patent/WO2006136461A2/en not_active Ceased
- 2006-06-22 JP JP2008517444A patent/JP2008543910A/en active Pending
- 2006-06-22 MX MX2008000072A patent/MX2008000072A/en not_active Application Discontinuation
- 2006-06-22 CA CA002611897A patent/CA2611897A1/en not_active Abandoned
- 2006-06-23 TW TW095122742A patent/TW200740778A/en unknown
- 2006-06-26 UY UY29624A patent/UY29624A1/en not_active Application Discontinuation
- 2006-06-26 DO DO2006000148A patent/DOP2006000148A/en unknown
- 2006-06-26 PE PE2006000733A patent/PE20070125A1/en not_active Application Discontinuation
- 2006-06-27 AR ARP060102750A patent/AR054519A1/en unknown
- 2006-06-28 GT GT200600271A patent/GT200600271A/en unknown
-
2007
- 2007-12-10 IL IL188021A patent/IL188021A0/en unknown
- 2007-12-17 CR CR9598A patent/CR9598A/en not_active Application Discontinuation
- 2007-12-21 EC EC2007008044A patent/ECSP078044A/en unknown
-
2008
- 2008-01-23 NO NO20080440A patent/NO20080440L/en not_active Application Discontinuation
- 2008-01-23 ZA ZA200800690A patent/ZA200800690B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006261048A1 (en) | 2006-12-28 |
| TW200740778A (en) | 2007-11-01 |
| NO20080440L (en) | 2008-03-25 |
| WO2006136461A2 (en) | 2006-12-28 |
| WO2006136461A3 (en) | 2007-03-15 |
| KR20080030622A (en) | 2008-04-04 |
| CR9598A (en) | 2008-04-09 |
| BRPI0611903A2 (en) | 2010-10-05 |
| IL188021A0 (en) | 2008-03-20 |
| CN101248066A (en) | 2008-08-20 |
| MX2008000072A (en) | 2008-03-24 |
| ZA200800690B (en) | 2009-09-30 |
| AR054519A1 (en) | 2007-06-27 |
| DOP2006000148A (en) | 2007-07-15 |
| JP2008543910A (en) | 2008-12-04 |
| PE20070125A1 (en) | 2007-02-14 |
| DE102005030292A1 (en) | 2007-01-11 |
| CA2611897A1 (en) | 2006-12-28 |
| EP1902049A2 (en) | 2008-03-26 |
| EA200702524A1 (en) | 2008-06-30 |
| GT200600271A (en) | 2007-02-05 |
| UY29624A1 (en) | 2007-01-31 |
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