ECSP088088A - Maleato de 3-[2-(dimetilamino)metil-(ciclohex-1-il)]fenol y sus formas cristalinas - Google Patents

Maleato de 3-[2-(dimetilamino)metil-(ciclohex-1-il)]fenol y sus formas cristalinas

Info

Publication number
ECSP088088A
ECSP088088A EC2008008088A ECSP088088A ECSP088088A EC SP088088 A ECSP088088 A EC SP088088A EC 2008008088 A EC2008008088 A EC 2008008088A EC SP088088 A ECSP088088 A EC SP088088A EC SP088088 A ECSP088088 A EC SP088088A
Authority
EC
Ecuador
Prior art keywords
phenol
methyl
crystalline forms
ciclohex
dimethylamine
Prior art date
Application number
EC2008008088A
Other languages
English (en)
Inventor
Wolfgang Hell
Martin Szelagiewicz
Michael Gruss
Jorg Berghausen
Paul Susan Margaret De
Raumer Markus Von
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of ECSP088088A publication Critical patent/ECSP088088A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a sales del ácido maleico y el compuesto 3-[2-(dimetilamino)metil-(ciclohex-1-il)]-fenol, preferentemente en una composición de 1:1, las formas cristalinas estables de la sal, además, de procedimientos para su preparación, una composición farmacéutica que las contiene y el uso de la sal como principio activo farmacéutico en una composición.
EC2008008088A 2005-07-22 2008-01-08 Maleato de 3-[2-(dimetilamino)metil-(ciclohex-1-il)]fenol y sus formas cristalinas ECSP088088A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005034974A DE102005034974A1 (de) 2005-07-22 2005-07-22 Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen

Publications (1)

Publication Number Publication Date
ECSP088088A true ECSP088088A (es) 2008-02-20

Family

ID=37084866

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008088A ECSP088088A (es) 2005-07-22 2008-01-08 Maleato de 3-[2-(dimetilamino)metil-(ciclohex-1-il)]fenol y sus formas cristalinas

Country Status (25)

Country Link
EP (1) EP1881956B1 (es)
JP (1) JP5205259B2 (es)
KR (1) KR20080033436A (es)
CN (1) CN101228110A (es)
AR (1) AR057674A1 (es)
AT (1) ATE431332T1 (es)
AU (1) AU2006271856B2 (es)
BR (1) BRPI0614057A2 (es)
CA (1) CA2615926A1 (es)
CY (1) CY1109208T1 (es)
DE (2) DE102005034974A1 (es)
DK (1) DK1881956T3 (es)
EC (1) ECSP088088A (es)
ES (1) ES2326493T3 (es)
HR (1) HRP20090412T1 (es)
IL (1) IL188897A (es)
MX (1) MX2008000743A (es)
NO (1) NO20080826L (es)
PE (1) PE20070368A1 (es)
PL (1) PL1881956T3 (es)
PT (1) PT1881956E (es)
RU (1) RU2434845C2 (es)
SI (1) SI1881956T1 (es)
WO (1) WO2007009792A1 (es)
ZA (1) ZA200801703B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
SI3173400T1 (sl) * 2007-12-07 2020-01-31 Gruenenthal Gmbh Zdravila, ki vsebujejo kristalinične modifikacije (1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenola
EP2085081A1 (de) 2008-02-04 2009-08-05 Grünenthal GmbH 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE10218862A1 (de) * 2002-04-26 2003-11-06 Gruenenthal Gmbh Verfahren zur Chlorierung tertiärer Alkohole
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen

Also Published As

Publication number Publication date
EP1881956B1 (de) 2009-05-13
RU2434845C2 (ru) 2011-11-27
PL1881956T3 (pl) 2009-10-30
CY1109208T1 (el) 2014-07-02
HK1112612A1 (zh) 2008-09-12
RU2008106455A (ru) 2009-08-27
WO2007009792A1 (de) 2007-01-25
NO20080826L (no) 2008-02-20
ZA200801703B (en) 2009-08-26
EP1881956A1 (de) 2008-01-30
PE20070368A1 (es) 2007-05-12
ES2326493T3 (es) 2009-10-13
DE102005034974A1 (de) 2007-04-19
MX2008000743A (es) 2008-03-10
HRP20090412T1 (hr) 2009-09-30
JP5205259B2 (ja) 2013-06-05
AU2006271856A1 (en) 2007-01-25
IL188897A0 (en) 2008-04-13
IL188897A (en) 2012-12-31
AR057674A1 (es) 2007-12-12
JP2009502757A (ja) 2009-01-29
SI1881956T1 (sl) 2009-10-31
KR20080033436A (ko) 2008-04-16
BRPI0614057A2 (pt) 2012-12-11
DK1881956T3 (da) 2009-09-07
AU2006271856B2 (en) 2012-03-01
CN101228110A (zh) 2008-07-23
PT1881956E (pt) 2009-06-26
CA2615926A1 (en) 2007-01-25
DE502006003728D1 (de) 2009-06-25
ATE431332T1 (de) 2009-05-15

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